Patents by Inventor Amanda E. Calvert

Amanda E. Calvert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapid detection of Zika virus by reverse transcription loop-mediated isothermal amplification
    Patent number: 11708613
    Abstract: A highly sensitive and specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay to detect ZIKV nucleic acid in biological samples is described. The disclosed assay is capable of detecting as few as one RNA copy per ?l and can be performed in a clinical or field setting with minimal equipment and technological expertise. Oligonucleotide primers and kits for detecting ZIKV nucleic acid are also described.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: July 25, 2023
    Assignee: The United States of America, as Represened by the Secretary, Department of Health and Human Services
    Inventor: Amanda E. Calvert
  • Monoclonal antibodies specific for heartland virus and methods of their use
    Patent number: 10584161
    Abstract: Monoclonal antibodies that specifically bind the nucleocapsid protein of Heartland virus (HRTV) are described. The monoclonal antibodies can be used, for example, in immunoassays to detect HRTV-specific antibodies in a biological sample or to detect HRTV in a cell or tissue sample. The monoclonal antibodies can also be used to diagnose or treat an HRTV infection.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: March 10, 2020
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Amanda E. Calvert, Aaron C. Brault
  • RAPID DETECTION OF ZIKA VIRUS BY REVERSE TRANSCRIPTION LOOP-MEDIATED ISOTHERMAL AMPLIFICATION
    Publication number: 20200063216
    Abstract: A highly sensitive and specific reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay to detect ZIKV nucleic acid in biological samples is described. The disclosed assay is capable of detecting as few as one RNA copy per ?l and can be performed in a clinical or field setting with minimal equipment and technological expertise. Oligonucleotide primers and kits for detecting ZIKV nucleic acid are also described.
    Type: Application
    Filed: April 27, 2018
    Publication date: February 27, 2020
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventor: Amanda E. Calvert
  • MONOCLONAL ANTIBODIES SPECIFIC FOR HEARTLAND VIRUS AND METHODS OF THEIR USE
    Publication number: 20180244757
    Abstract: Monoclonal antibodies that specifically bind the nucleocapsid protein of Heartland virus (HRTV) are described. The monoclonal antibodies can be used, for example, in immunoassays to detect HRTV-specific antibodies in a biological sample or to detect HRTV in a cell or tissue sample. The monoclonal antibodies can also be used to diagnose or treat an HRTV infection.
    Type: Application
    Filed: January 12, 2016
    Publication date: August 30, 2018
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Amanda E. Calvert, Aaron C. Brault