Patents by Inventor Amanda E. Sutton

Amanda E. Sutton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof
    Patent number: 9938268
    Abstract: Disclosed are C-ring modified tricyclic benzonaphthiridinone compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: April 10, 2018
    Assignee: Merck Patent GmbH
    Inventors: Yufang Xiao, Bayard R. Huck, Amanda E. Sutton, Thomas E. Richardson, Srinivasa R. Karra
  • Spiro-quinazolinone derivatives and their use as positive allosteric modulators of mGluR4
    Patent number: 9708321
    Abstract: The present invention relates to novel spiro-quinazolinone derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: July 18, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Nadia Brugger, Brian L. Hodous, Amanda E. Sutton, Justin Potnick, Theresa L. Johnson, Thomas E. Richardson, Thomas Francis Nelson Haxell, James M. Dorsey, Robert James Foglesong
  • Spiro-Quinazolinone Derivatives and their Use as Positive Allosteric Modulators of mGluR4
    Publication number: 20150361079
    Abstract: The present invention relates to novel spiro-quinazolinone derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mGluR4) and/or altering glutamate level or glutamatergic signalling.
    Type: Application
    Filed: January 23, 2014
    Publication date: December 17, 2015
    Applicant: Merck Patent GMBH
    Inventors: Nadia BRUGGER, Brian L. HODOUS, Amanda E. SUTTON, Justin POTNICK, Theresa L. JOHNSON, Thomas E. RICHARDSON, Thomas Francis Nelson HAXELL, James M. DORSEY, Robert James FOGLESONG
  • Amino azaheterocyclic carboxamides
    Patent number: 9040560
    Abstract: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: May 26, 2015
    Assignee: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Thomas E. Richardson, Bayard R. Huck, Srinivasa R. Karra, Xiaoling Chen, Yufang Xiao, Andreas Goutopoulos, Ruoxi Lan, David Perrey, Harold George Vandeveer, Lesley Liu-Bujalski, Frank Stieber, Brian L. Hodous, Hui Qiu, Reinaldo C. Jones, Brian H. Heasley
  • Azaheterocyclic compounds
    Patent number: 9023847
    Abstract: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: May 5, 2015
    Assignee: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Nadia Brugger, Thomas E. Richardson, Harold George Vandeveer, Bayard R. Huck, Ruoxi Lan, Justin Potnick
  • Furopyridine derivatives
    Patent number: 9006440
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis and/or systemic lupus.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: April 14, 2015
    Assignee: Merck Patent GmbH
    Inventors: Lars Burgdorf, Melanie Schultz, Tatjana Ross, Brian Hodous, Justin Potnick, Amanda E. Sutton, Bayard R. Huck
  • Tricyclic azaindoles
    Patent number: 8853391
    Abstract: Disclosed are dipyridyl-pyrrole derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: October 7, 2014
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Amanda E. Sutton, Benny C. Askew, Jr., Christopher Charles Victor Jones, Garry R. Smith, Nadia Brugger
  • Protein kinase inhibitors and use thereof
    Patent number: 8735584
    Abstract: Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: May 27, 2014
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Xiaoling Chen, Lizbeth Celeste Deselm, Christopher Charles Victor Jones, Srinivasa R. Karra, Yufang Xiao, Andreas Goutopoulos, Amanda E. Sutton
  • Bicyclic azaheterocyclic carboxamides
    Patent number: 8710044
    Abstract: The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: April 29, 2014
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Constantin Neagu, Reinaldo Jones, Lizbeth Celeste DeSelm, Yufang Xiao, Srinivasa R. Karra, Ruoxi Lan, Igor Mochalkin, Amanda E. Sutton, Thomas E. Richardson
  • Novel Amino Azaheterocyclic Carboxamides
    Publication number: 20140107156
    Abstract: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: December 13, 2013
    Publication date: April 17, 2014
    Applicant: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Thomas E. Richardson, Bayard R. Huck, Srinivasa R. Karra, Xiaoling Chen, Yufang Xiao, Andreas Goutopoulos, Ruoxi Lan, David Perrey, Harold George Vandeveer, Lesley Liu-Bujalski, Frank Steiber, Hui Qiu, Reinaldo C. Jones, Brian H. Heasley
  • Amino azaheterocyclic carboxamides
    Patent number: 8637532
    Abstract: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: January 28, 2014
    Assignee: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Ruoxi Lan, Thomas E. Richardson, David Perrey, Harold George Vandeveer, Bayard R. Huck, Srinivasa R. Karra, Xiaoling Chen, Yufang Xiao, Lesley Liu-Bujalski, Andreas Goutopoulos, Frank Stieber, Brian L. Hodous, Hui Qiu, Reinaldo Jones, Brian H. Heasley
  • Bicyclic urea compounds
    Patent number: 8569295
    Abstract: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: October 29, 2013
    Assignee: Merck Patent GmbH
    Inventors: Xiaoling Chen, Srinivasa R. Karra, Bayard R. Huck, Ruoxi Lan, Amanda E. Sutton, Andreas Goutopoulos, Brian L. Hodous, Reinaldo Jones
  • FUROPYRIDINE DERIVATIVES
    Publication number: 20130225569
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis and/or systemic lupus
    Type: Application
    Filed: July 29, 2011
    Publication date: August 29, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Lars Burgdorf, Melanie Schultz, Tatjana Ross, Brian Hodous, Justin Potnick, Amanda E. Sutton, Bayard R. Huck
  • Bicyclic Azaheterocyclic Carboxamides
    Publication number: 20130137677
    Abstract: The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: July 1, 2011
    Publication date: May 30, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Bayard R. Huck, Constantin Neagu, Reinaldo Jones, Lizbeth Celeste DeSelm, Yufang Xiao, Srinivasa R. Karra, Ruoxi Lan, Igor Mochalkin, Amanda E. Sutton, Thomas E. Richardson
  • Novel Azaheterocyclic Compounds
    Publication number: 20120277228
    Abstract: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: July 22, 2010
    Publication date: November 1, 2012
    Inventors: Amanda E. Sutton, Nadia Brugger, Thomas E. Richardson, Harold George Vandeveer, Bayard R. Huck, Ruoxi Lan, Justin Potnick
  • NOVEL BICYCLIC UREA COMPOUNDS
    Publication number: 20120190654
    Abstract: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: July 28, 2010
    Publication date: July 26, 2012
    Applicant: MERCK PATENT GMBH
    Inventors: Xiaoling Chen, Srinivasa R. Karra, Bayard R. Huck, Ruoxi Lan, Amanda E. Sutton, Andreas Goutopoulos, Brian L. Hodous, Reinaldo Jones
  • Novel Amino Azaheterocyclic Carboxamides
    Publication number: 20120046269
    Abstract: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Application
    Filed: February 4, 2010
    Publication date: February 23, 2012
    Applicant: Merck Patent GmbH
    Inventors: Amanda E. Sutton, Ruoxi Lan, Thomas E. Richardson, David Perrey, Harold George Vandeveer, Bayard R. Huck, Srinivasa R. Karra, Xiaoling Chen, Lesley Liu-Bujalski, Andreas Goutopoulos, Frank Steiber, Brian L. Hodous, Hui Qiu, Reinaldo C. Jones, Brian H. Heasley
  • Tricyclic Azaindoles
    Publication number: 20120022060
    Abstract: Disclosed are dipyridyl-pyrrole derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
    Type: Application
    Filed: December 3, 2009
    Publication date: January 26, 2012
    Applicant: MERCK PATENT GMBH
    Inventors: Bayard R. Huck, Amanda E. Sutton, Benny C. Askew, JR., Christopher Charles Victor Jones, Garry R. Smith, Nadia Brugger
  • C-Ring Modified Tricyclic Benzonaphthiridinone Protein Kinase Inhibitors and Use Thereof
    Publication number: 20110312951
    Abstract: Disclosed are C-ring modified tricyclic benzonaphthiridinone compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
    Type: Application
    Filed: December 2, 2009
    Publication date: December 22, 2011
    Applicant: MERCK PATENT GMBH
    Inventors: Yufang Xiao, Bayard R. Huck, Amanda E. Sutton, Thomas E. Richardson, Srinivasa R. Karra
  • PROTEIN KINASE INHIBITORS AND USE THEREOF
    Publication number: 20110282056
    Abstract: Disclosed are compounds according to Formula I: wherein the variables are described herein.
    Type: Application
    Filed: January 20, 2009
    Publication date: November 17, 2011
    Applicant: MERCK PATENT GMBH
    Inventors: Benny C. Askew, Nadia Brugger, Ruoxi Lan, Amanda E. Sutton