Patents by Inventor Amanda Ewan

Amanda Ewan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compounds as imaging probes of tau pathology
    Patent number: 9040021
    Abstract: Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: May 26, 2015
    Assignee: GE Healthcare Limited
    Inventors: Clare Jones, Amanda Ewan, Duncan Wynn, Alessandra Gaeta, James Nairne
  • INDOLE DERIVATIVES
    Publication number: 20140364615
    Abstract: An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 11, 2014
    Applicant: GE HEALTHCARE LIMITED
    Inventors: HARRY JOHN WADSWORTH, DENNIS O'SHEA, JOANNA PASSMORE, WILLIAM TRIGG, AMANDA EWAN, BO SHAN
  • Indole derivatives
    Patent number: 8790619
    Abstract: An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: July 29, 2014
    Assignee: GE Healthcare Limited
    Inventors: Harry John Wadsworth, Bo Shan, Dennis O'Shea, Joanna Marie Passmore, William John Trigg, Amanda Ewan
  • HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY
    Publication number: 20130236395
    Abstract: Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.
    Type: Application
    Filed: November 7, 2011
    Publication date: September 12, 2013
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Clare Jones, Amanda Ewan, Duncan Wynn, Alessandra Gaeta, James Nairne
  • Chelating agents
    Patent number: 8158804
    Abstract: The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI contrast agents.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: April 17, 2012
    Assignee: GE Healthcare AS
    Inventors: Harry John Wadsworth, Ian Martin Newington, Clare L. Jones, Amanda Ewan, Dennis O'Shea
  • INDOLE DERIVATIVES
    Publication number: 20120020884
    Abstract: An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
    Type: Application
    Filed: March 26, 2010
    Publication date: January 26, 2012
    Inventors: Harry John Wadsworth, Bo Shan, Dennis O'shea, Joanna Marie Passmore, William John Trigg, Amanda Ewan
  • CHELATING AGENTS
    Publication number: 20100056787
    Abstract: The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI contrast agents.
    Type: Application
    Filed: January 11, 2008
    Publication date: March 4, 2010
    Applicant: GE Healthcare AS
    Inventors: Harry John Wadsworth, Ian Martin Newington, Clare L. Jones, Amanda Ewan, Dennis O'Sheo
  • AROMATIC MULTIMERS
    Publication number: 20100008864
    Abstract: The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
    Type: Application
    Filed: July 8, 2009
    Publication date: January 14, 2010
    Inventors: Andreas Meijer, Harry John Wadsworth, Ian Martin Newington, Clare L. Jones, Amanda Ewan, Dennis O'Shea, Oskar Axelsson, Anders Brathe, Andreas Olsson, John Henrik Johansen, Duncan George Wynn