Abstract: Devices and methods for bio-specimen refrigeration are provided. In an embodiment, the bio-specimen refrigeration devices of the present disclosure include a housing having a lid and a base portion, wherein the lid is selectively moveable between an open position and a closed position; a coolant cartridge chamber disposed in the housing and configured to fluidically couple with a coolant cartridge disposed in the coolant cartridge chamber; and a cooling chamber disposed in the housing and configured to receive a fluid coolant from the coolant cartridge, wherein in the closed position, the lid seals the cooling chamber.

Abstract: The present invention provides methods, reagents, kits and devices for carrying out a diagnostic assay for use in assessing the exposure to ionizing radiation in a biological sample of interest.

Abstract: In one aspect, the invention provides a kit for detecting the presence or amount of a target modified protein within a sample. The kit comprises (i) a capture reagent that specifically binds to a first epitope on the target protein; (ii) at least one detection reagent that specifically binds to a second epitope on the target protein; and (iii) at least one synthetic hybrid reference peptide comprising the first epitope and the second epitope from the target protein of interest, wherein the synthetic reference peptide is capable of simultaneously binding to both the capture reagent and the at least one detection reagent, and wherein at least one of the first and second epitopes comprises a modified amino acid residue.