Abstract: Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.

Abstract: In one embodiment, a method includes receiving program content and data describing program content from a content source, and automatically identifying, based on user preferences of a first user, one or more relevant products or services displayed in the program content. Product-related metadata associated with the program content is identified. The product-related metadata including data relating to the one or more relevant products or services displayed in the program content. The program content is communicated to a display device for presentation to a first user in a first portion of the display device, and the product-related metadata is communicated to a second display device for presentation to a second user substantially simultaneously with the presentation of the program content in the first display device. A user commentary is received from the second device, the user commentary generated by the second user and associated with the program content or product-related metadata.

Abstract: In one embodiment, a method includes receiving program content and data describing program content from a content source, and automatically identifying, based on user preferences of a first user, one or more relevant products or services displayed in the program content. Product-related metadata associated with the program content is identified. The product-related metadata including data relating to the one or more relevant products or services displayed in the program content. The program content is communicated to a display device for presentation to a first user in a first portion of the display device, and the product-related metadata is communicated to a second display device for presentation to a second user substantially simultaneously with the presentation of the program content in the first display device. A user commentary is received from the second device, the user commentary generated by the second user and associated with the program content or product-related metadata.

Abstract: In one embodiment, a method includes receiving program content and data describing program content from a content source, and automatically identifying, based on user preferences of a first user, one or more relevant products or services displayed in the program content. Product-related metadata associated with the program content is identified. The product-related metadata including data relating to the one or more relevant products or services displayed in the program content. The program content is communicated to a display device for presentation to a first user in a first portion of the display device, and the product-related metadata is communicated to a second display device for presentation to a second user substantially simultaneously with the presentation of the program content in the first display device. A user commentary is received from the second device, the user commentary generated by the second user and associated with the program content or product-related metadata.

Abstract: In one embodiment, a method includes receiving program content and data describing program content from a content source, and automatically identifying, based on user preferences of a first user, one or more relevant products or services displayed in the program content. Product-related metadata associated with the program content is identified. The product-related metadata including data relating to the one or more relevant products or services displayed in the program content. The program content is communicated to a display device for presentation to a first user in a first portion of the display device, and the product-related metadata is communicated to a second display device for presentation to a second user substantially simultaneously with the presentation of the program content in the first display device. A user commentary is received from the second device, the user commentary generated by the second user and associated with the program content or product-related metadata.

Abstract: Systems, methods and media for purchasing and commenting on identified products in media content are provided. In one example, a method comprises receiving media content from a content source and accessing data relating to an aspect of the media content, such as a product or service shown in the media content. The media content is communicated to first and second display devices for presentation to respective first and second users, and the data relating to an aspect of the media content is also sent to the first and second devices for presentation to the first and second users at about the same time. User commentary generated by the first or second user associated with the media content or the data relating to an aspect of the media content is received from the first or second device.

Abstract: Systems, methods and media for purchasing and commenting on identified products in media content are provided. In one example, a method comprises receiving media content from a content source and accessing data relating to an aspect of the media content, such as a product or service shown in the media content. The media content is communicated to first and second display devices for presentation to respective first and second users, and the data relating to an aspect of the media content is also sent to the first and second devices for presentation to the first and second users at about the same time. User commentary generated by the first or second user associated with the media content or the data relating to an aspect of the media content is received from the first or second device.

Abstract: Systems, methods and media for purchasing and commenting on identified products in streamed media are provided. In one example, a method comprises receiving program content and data describing program content from a content source and identifying product-related metadata associated with the program content. The product-related metadata includes data relating to one or more products or services displayed in the program content. In one embodiment, the program content is communicated to a display device for presentation to a first user in the display device. User commentary is received from a second device and communicated to the first user while the first user is viewing the program content. Commentaries of other users, for example in a wider social group, can also be presented to the first user.

Abstract: Systems, methods and media for purchasing and commenting on identified products in streamed media are provided. In one example, a method comprises receiving program content and data describing program content from a content source and identifying product-related metadata associated with the program content. The product-related metadata includes data relating to one or more products or services displayed in the program content. In one embodiment, the program content is communicated to a display device for presentation to a first user in the display device. User commentary is received from a second device and communicated to the first user while the first user is viewing the program content. Commentaries of other users, for example in a wider social group, can also be presented to the first user.

Abstract: In one embodiment, a method includes receiving program content and data describing program content from a content source, and automatically identifying, based on user preferences of a first user, one or more relevant products or services displayed in the program content. Product-related metadata associated with the program content is identified. The product-related metadata including data relating to the one or more relevant products or services displayed in the program content. The program content is communicated to a display device for presentation to a first user in a first portion of the display device, and the product-related metadata is communicated to a second display device for presentation to a second user substantially simultaneously with the presentation of the program content in the first display device. A user commentary is received from the second device, the user commentary generated by the second user and associated with the program content or product-related metadata.

Abstract: In one embodiment, a method includes receiving program content and data describing program content from a content source, and automatically identifying, based on user preferences of a first user, one or more relevant products or services displayed in the program content. Product-related metadata associated with the program content is identified. The product-related metadata including data relating to the one or more relevant products or services displayed in the program content. The program content is communicated to a display device for presentation to a first user in a first portion of the display device, and the product-related metadata is communicated to a second display device for presentation to a second user substantially simultaneously with the presentation of the program content in the first display device. A user commentary is received from the second device, the user commentary generated by the second user and associated with the program content or product-related metadata.

Abstract: Systems and methods to display content are described. In some embodiments, program content is received from a content source. A method identifies product-related metadata associated with the program content where the product-related metadata includes at least one item displayed in the program content. The program content is communicated to a display device for presentation to a user in a first portion of the display device. The product-related metadata is communicated to the display device for presentation to the user in a second portion of the display device.

Abstract: Systems and methods to display content are described. In some embodiments, program content is received from a content source. A method identifies product-related metadata associated with the program content where the product-related metadata includes at least one item displayed in the program content. The program content is communicated to a display device for presentation to a user in a first portion of the display device. The product-related metadata is communicated to the display device for presentation to the user in a second portion of the display device.

Abstract: Systems and methods to display content are described. In some embodiments, program content is received from a content source. A method identifies product-related metadata associated with the program content where the product-related metadata includes at least one item displayed in the program content. The program content is communicated to a display device for presentation to a user in a first portion of the display device. The product-related metadata is communicated to the display device for presentation to the user in a second portion of the display device.

Abstract: Systems and methods to display content are described. In some embodiments, program content is received from a content source. A method identifies product-related metadata associated with the program content where the product-related metadata includes at least one item displayed in the program content. The program content is communicated to a display device for presentation to a user in a first portion of the display device. The product-related metadata is communicated to the display device for presentation to the user in a second portion of the display device.

Abstract: A car seat alarm has an on/off switch that is initiated by clicking the latch on the car seat. (“Pumpkin” or removable carrier infant seats may use a two-part switch.) Initiating the circuit when clicking the child into the seat would conserve battery life. The device would be off when the seat is unlocked. Additionally, if an occasion arose where a parent or caregiver were sitting in the vehicle with a child and needed to have the engine off, that parent or caregiver would simply need to unclick or unlock the child car seat restraint to deactivate the device. A learning or programmable chip can be programmed to the same frequency as the panic button on the key fob. This may be done by pressing the panic button on the key fob in close proximity to the learning circuit on the seat.

Abstract: The invention is concerned with improvements relating to fabric care and in particular to means by which the apparent ageing of clothes can be reduced or retarded. Colour loss during laundering, as opposed to during wear, is a significant source of colour loss. We have determined that this problem may be overcome by use of a lubricant during the laundering process, to prevent the visible appearance of local colour loss through mechanical damage by the laundering process.

Abstract: A shrink-sleeved bottle is disclosed. The bottle has a base, a top part and sides. The bottle has a handle located on a side of the bottle and a sleeve that covers the handle. The sleeve has a cut-out that allows a user to grip the handle, and a fringe that is maintained flush against the bottle.

Abstract: A shrink-sleeved bottle is disclosed. The bottle has a base, a top part and sides. The bottle has a handle located on a side of the bottle and a sleeve that covers the handle. The sleeve has a cut-out that allows a user to grip the handle, and a fringe that is maintained flush against the bottle.