Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: A valve for a reclosable container comprises first and second opposing layers of a film material, wherein an overlap region of the second layer overlaps the container, and the first layer is sealed to the second layer around a portion of the second layer. The second layer is sealed to the container around a periphery of the overlap region, and opposing surfaces of the first and second layers form a substantially airtight seal therebetween upon direct contact of the layers. First and second offset apertures extend through the first and second layers, respectively. One of the first and second apertures is in fluid communication with an interior of the container and the other of the first and second apertures is in fluid communication with an exterior of the container. Vacuum pressure disposed over both of the first and second apertures causes the first layer to separate from the second layer to allow air to exhaust from the container.

Abstract: A valve for a reclosable container comprises first and second opposing layers of a film material, wherein an overlap region of the second layer overlaps the container, and the first layer is sealed to the second layer around a portion of the second layer. The second layer is sealed to the container around a periphery of the overlap region, and opposing surfaces of the first and second layers form a substantially airtight seal therebetween upon direct contact of the layers. First and second offset apertures extend through the first and second layers, respectively. One of the first and second apertures is in fluid communication with an interior of the container and the other of the first and second apertures is in fluid communication with an exterior of the container. Vacuum pressure disposed over both of the first and second apertures causes the first layer to separate from the second layer to allow air to exhaust from the container.