Abstract: A coated substrate is disclosed, including a solvent-sensitive substrate and a polyester coating disposed on the solvent-sensitive substrate, wherein the polyester coating includes a polyester copolymer of a polyol and a polyacid. A method for forming a coated substrate is disclosed including spraying solvated polyester material from a spray nozzle onto a solvent-sensitive substrate and drying the solvated polyester material to form a polyester disposed on the solvent-sensitive substrate, wherein the solvated polyester material and the polyester coating include a polyester copolymer of a polyol and a polyacid.

Abstract: A suture-free stent graft is disclosed including a woven graft tube having woven extensions extending from an outer face of the woven graft tube. Each of the woven extensions is integrally woven with the woven graft tube such that warp from the woven graft tube is de-interlaced from at a first end and re-interlaced at a second end. Supplemental warp is interlaced into the woven graft tube in replacement of the deinterlaced warp so as to maintain weave density in the woven graft tube under the woven extensions. The woven extensions and portions of the woven graft tube disposed directly under the woven extension have independent weft from one another. A suture-free stent graft construct is disclosed including the suture-free stent graft and at least one stent wire disposed about the suture-free stent graft, at least partially disposed between the woven graft tube and the woven extensions at securement sites.

Abstract: An integrally woven manifold is disclosed including a primary portion having a primary lumen disposed therein, a secondary portion branching off the primary portion, the secondary portion having a secondary lumen disposed therein in fluid communication with the primary lumen, and a first transitional portion connecting the primary portion to the secondary portion, the first transitional portion having a first aperture through which the secondary lumen fluidly communicates with the primary lumen. The primary portion has a first weave pattern, the secondary portion has at least a second weave pattern, and the first transitional portion is free of punctures, cuts, and bursts. A method for forming the integrally woven manifold is disclosed including continuously interlacing warp and weft to form the primary portion, intermittently interlacing the warp and the weft to form the secondary portion, and disengaging and reengaging the warp and the weft to form the first transitional portion.

Abstract: A leaflet for a heart valve replacement includes poly(glycerol sebacate) urethane. A heart valve replacement includes a leaflet including poly(glycerol sebacate) urethane. A process forms a leaflet for a heart valve replacement. The process includes casting a first solution including poly(glycerol sebacate) and isocyanate to form a leaflet composition including poly(glycerol sebacate) urethane. The process also includes shaping the leaflet composition to form the leaflet.

Abstract: A heat-activated crimping textile is disclosed including a plurality of a first yarn, a plurality of a second yarn interlaced with the plurality of the first yarn, and a plurality of a third yarn interlaced with the plurality of the first yarn, the plurality of the second yarn, or both. The third yarn includes a heat-activated shrinkage factor of greater than 30% when exposed to a predetermined temperature. When the heat-activated crimping textile is exposed to an elevated temperature of at least the predetermined temperature, a plurality of crimps propagates along the heat-activated crimping textile, forming a crimped textile.

Abstract: A delivery system is described that includes a controlled release device that includes a crosslinked poly(glycerol sebacate) (PGS) or other glycerol ester and a controlled release compound, the controlled release device being provided in a contracted state and being expandable to a three-dimensional expanded state in a target location. The delivery systems provides an expandible, flexible biodegradable elastomer loaded with an active ingredient to allow for extended release for different dosage forms for either human or animal health products in vivo, delivered through the gastrointestinal tract.

Abstract: A modular flow-through cartridge bioreactor system includes a plurality of modular flow-through cartridges. Each modular flow-through cartridge includes a cartridge housing with ports for through flow of a biological media and predetermined contents preloaded in the cartridge housing permitting the cartridge to perform at least one predetermined function of the bioreactor process upon through-flow of the biological media. The modular flow-through cartridge bioreactor system also includes at least one interlock connector fluidly connecting the plurality of modular flow-through cartridges by the ports. A modular flow through cartridge includes rows of porous textiles preloaded in the cartridge housing. A process includes selecting a plurality of modular flow-through cartridges to perform, in combination, a bioreactor process. The process also includes fluidly connecting the modular flow-through cartridges in a fluid sequence to form the modular flow-through cartridge bioreactor system.

Abstract: A engineered textile construction includes a first textile having a first average pore size forming a textile cell growth matrix in which the first textile is a woven or a knit construction, the textile cell growth matrix is configured to have a surface area sufficient to promote cell expansion and the first average pore size is preselected to prevent filling of the pores during cell expansion.