Patents by Inventor Amanda Louise Boase

Amanda Louise Boase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gamma-secretase inhibitors
    Patent number: 7452899
    Abstract: Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: November 18, 2008
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Michela Bettati, Amanda Louise Boase, Ian Churcher, Tamara Ladduwahetty, Kevin John Merchant, Abdul Quddus
  • Cognition enhancing derivatives of isoxazole triazoloindane GABA-A ?5 receptor subunit ligands
    Patent number: 7022724
    Abstract: The present invention relates to compounds of formula I: in which R1 is a linear group or a five membered heterocycle optionally fused to a phenyl ring, R2 is a 5-membered heterocycle, R3 is chosen from a range of substituents, m is 0–3 and n is 0 or 1; the compounds are generally inverse agonists at GABA-A receptors containing the alpha 5 subunit and so are useful in methods of enhancing cognition in subjects with diminished cognition in diseases such as Alzheimer's Disease.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: April 4, 2006
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Amanda Louise Boase, Tamara Ladduwahetty, Angus Murray MacLeod, Kevin John Merchant
  • Cognition enhancing derivatives of isoxazole triazoloindane GABA-A alpha 5 receptor subunit ligands
    Publication number: 20040058970
    Abstract: The present invention relates to compounds of formula I: 1
    Type: Application
    Filed: October 22, 2002
    Publication date: March 25, 2004
    Inventors: Amanda Louise Boase, Tamara Ladduwahetty, Angus Murray MacLeod, Kevin John Merchant