Patents by Inventor Amanda Mack

Amanda Mack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATION OF INDUCED PLURIPOTENT STEM CELLS FROM SMALL VOLUMES OF PERIPHERAL BLOOD
    Publication number: 20240228977
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.
    Type: Application
    Filed: August 14, 2023
    Publication date: July 11, 2024
    Applicant: FUJIFILM Cellular Dynamics, Inc.
    Inventor: Amanda MACK
  • Generation of induced pluripotent stem cells from small volumes of peripheral blood
    Patent number: 10260048
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: April 16, 2019
    Assignee: FUJIFILM Cellular Dynamics, Inc.
    Inventor: Amanda Mack
  • Reprogramming T cells and hematopoietic cells
    Patent number: 10221396
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: March 5, 2019
    Assignee: FUJIFILM Cellular Dynamics, Inc.
    Inventors: Matthew Brown, Elizabeth Rondon Dominguez, Randy Learish, Emile Nuwaysir, Deepika Rajesh, Amanda Mack
  • METHODS FOR THE PRODUCTION OF IPS CELLS USING NON-VIRAL APPROACH
    Publication number: 20180340150
    Abstract: Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors.
    Type: Application
    Filed: December 15, 2017
    Publication date: November 29, 2018
    Applicant: Cellular Dynamics International, Inc.
    Inventor: Amanda MACK
  • REPROGRAMMING T CELLS AND HEMATOPOIETIC CELLS
    Publication number: 20170226484
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
    Type: Application
    Filed: April 26, 2017
    Publication date: August 10, 2017
    Applicant: Cellular Dynamics International, Inc.
    Inventors: Matthew BROWN, Elizabeth Rondon DOMINGUEZ, Randy LEARISH, Emile NUWAYSIR, Deepika RAJESH, Amanda MACK
  • Methods for the production of IPS cells using Epstein-Barr (EBV)-based reprogramming vectors
    Patent number: 9644184
    Abstract: Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: May 9, 2017
    Assignee: Cellular Dynamics International, Inc.
    Inventor: Amanda Mack
  • GENERATION OF INDUCED PLURIPOTENT STEM CELLS FROM SMALL VOLUMES OF PERIPHERAL BLOOD
    Publication number: 20170088818
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.
    Type: Application
    Filed: August 10, 2016
    Publication date: March 30, 2017
    Applicant: Cellular Dynamics International, Inc.
    Inventor: Amanda MACK
  • Generation of induced pluripotent stem cells from small volumes of peripheral blood
    Patent number: 9447382
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: September 20, 2016
    Assignee: Cellular Dynamics International, Inc.
    Inventor: Amanda Mack
  • REPROGRAMMING T CELLS AND HEMATOPOIETIC CELLS
    Publication number: 20160257939
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
    Type: Application
    Filed: April 27, 2016
    Publication date: September 8, 2016
    Applicant: Cellular Dynamics International, Inc.
    Inventors: Matthew BROWN, Elizabeth Rondon DOMINGUEZ, Randy LEARISH, Emile NUWAYSIR, Deepika RAJESH, Amanda MACK
  • Reprogramming T cells and hematopoietic cells
    Patent number: 9347044
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 24, 2016
    Assignee: Cellular Dynamics International, Inc.
    Inventors: Matthew Brown, Elizabeth Rondon Dominguez, Randy Learish, Emile Nuwaysir, Deepika Rajesh, Amanda Mack
  • Methods for the production of IPS cells using non-viral approach
    Patent number: 9328332
    Abstract: Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: May 3, 2016
    Assignee: Cellular Dynamics International, Inc.
    Inventor: Amanda Mack
  • Methods for the production of iPS cells
    Patent number: 9175268
    Abstract: Methods and composition of induction of pluripotent stem cells are disclosed. For example, in certain aspects methods for generating induced pluripotent stem cells using reporter genes are described. Furthermore, the invention provides novel reprogramming vectors employing reporter genes.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: November 3, 2015
    Assignee: Cellular Dynamics International, Inc.
    Inventor: Amanda Mack
  • REPROGRAMMING IMMORTALIZED B CELLS
    Publication number: 20140349397
    Abstract: Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement.
    Type: Application
    Filed: May 21, 2014
    Publication date: November 27, 2014
    Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC.
    Inventors: James THOMSON, Deepika RAJESH, Sarah Jane DICKERSON, Amanda MACK, Michael MILLER
  • REPROGRAMMING T CELLS AND HEMATOPOIETIC CELLS
    Publication number: 20140315304
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
    Type: Application
    Filed: April 22, 2014
    Publication date: October 23, 2014
    Applicant: Cellular Dynamics International, Inc.
    Inventors: Matthew BROWN, Elizabeth Rondon DOMINGUEZ, Randy LEARISH, Emile NUWAYSIR, Deepika RAJESH, Amanda MACK
  • GENERATION OF INDUCED PLURIPOTENT STEM CELLS FROM SMALL VOLUMES OF PERIPHERAL BLOOD
    Publication number: 20140234973
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 21, 2014
    Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC.
    Inventor: Amanda MACK
  • Reprogramming immortalized B-cells to induced pluripotent stem cells
    Patent number: 8765470
    Abstract: Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: July 1, 2014
    Assignee: Cellular Dynamics International, Inc.
    Inventors: James Thomson, Deepika Rajesh, Sarah Jane Dickerson, Amanda Mack, Michael Miller
  • Reprogramming T cells and hematopoietic cells
    Patent number: 8741648
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: June 3, 2014
    Assignee: Cellular Dynamics International, Inc.
    Inventors: Deepika Rajesh, Amanda Mack
  • Generation of induced pluripotent stem cells from small volumes of peripheral blood
    Patent number: 8691574
    Abstract: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: April 8, 2014
    Assignee: Cellular Dynamics International, Inc.
    Inventor: Amanda Mack
  • METHODS FOR THE PRODUCTION OF IPS CELLS USING NON-VIRAL APPROACH
    Publication number: 20140038293
    Abstract: Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors.
    Type: Application
    Filed: August 7, 2013
    Publication date: February 6, 2014
    Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC.
    Inventor: Amanda MACK
  • Methods for the production of iPS cells using non-viral approach
    Patent number: 8546140
    Abstract: Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described. Furthermore, the invention provides induced pluripotent stem cells and desired cell types essentially free of exogenous vector elements with the episomal expression vectors to express differentiation programming factors.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: October 1, 2013
    Assignee: Cellular Dynamics International, Inc.
    Inventors: Amanda Mack, James Thomson