Patents by Inventor Amanda McFedries

Amanda McFedries has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ASSAY FOR INSULIN-DEGRADING ENZYME (IDE) INHIBITORS
    Publication number: 20160282364
    Abstract: IDE-binding probes and assays for the identification of IDE-binding and IDE-inhibiting compounds are provided. Pharmaceutical compositions of macrocyclic IDE inhibitors are also provided, including compositions in which such IDE inhibitors are combined with an additional therapeutic agent. Methods of using IDE inhibitors for transiently inhibiting IDE in a subject in need thereof, for example, for the transient inhibition of IDE in a subject exhibiting aberrant IDE activity, impaired isulin signaling, or insulin resistance, for example, a subject having diabetes, are also provided. Methods of using IDE inhibitors for transiently modulating heart rate and/or blood pressure in a subject are also provided.
    Type: Application
    Filed: November 6, 2014
    Publication date: September 29, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Juan Pablo Maianti, Amanda McFedries, Ralph E. Kleiner, Alan Saghatelian, David R. Liu