Patents by Inventor Amanda McNulty

Amanda McNulty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Coupling adaptors to a target nucleic acid
    Patent number: 10655170
    Abstract: Methods of coupling adaptors to a target nucleic acid include coupling a first adaptor to a first end of the target nucleic acid to form a coupled first adaptor. A portion of a second adaptor is hybridized to a portion of the coupled first adaptor to form a hybridized second adaptor having a single-stranded 3?-end. The hybridized second adaptor is coupled to a second end of the target nucleic acid to form an adaptor-flanked product having at least a part of the first adaptor coupled to the first end of the target nucleic acid and at least a part of the second adaptor coupled to the second end of the target nucleic acid. These methods can minimize the formation of adaptor-dimers that may be problematic in subsequent complementary nucleic acid strand synthesis, amplification, and sequencing.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: May 19, 2020
    Assignee: Takara Bio USA, Inc.
    Inventors: Konstantinos Charizanis, Marta Gonzalez-Hernandez, Amanda McNulty, Karl Hecker, Emmanuel Kamberov, John Langmore
  • COUPLING ADAPTORS TO A TARGET NUCLEIC ACID
    Publication number: 20180010178
    Abstract: Methods of coupling adaptors to a target nucleic acid include coupling a first adaptor to a first end of the target nucleic acid to form a coupled first adaptor. A portion of a second adaptor is hybridized to a portion of the coupled first adaptor to form a hybridized second adaptor having a single-stranded 3?-end. The hybridized second adaptor is coupled to a second end of the target nucleic acid to form an adaptor-flanked product having at least a part of the first adaptor coupled to the first end of the target nucleic acid and at least a part of the second adaptor coupled to the second end of the target nucleic acid. These methods can minimize the formation of adaptor-dimers that may be problematic in subsequent complementary nucleic acid strand synthesis, amplification, and sequencing.
    Type: Application
    Filed: July 5, 2017
    Publication date: January 11, 2018
    Inventors: Konstantinos Charizanis, Marta Gonzalez-Hernandez, Amanda McNulty, Karl Hecker, Emmanuel Kamberov, John Langmore