Abstract: Provided are agents and methods for preventing or inhibiting a multiple sclerosis (MS)-associated adaptive immune response in a subject in need thereof. In some instances, the agents comprise or consist of a soluble peptide-major histocompatibility complex (pMHC) or multimer(s) thereof. The peptide of the pMHC is one identified as being targeted by MS-associated T-cell receptors (TCRs). The agents may be used alone or may be conjugated or fused to one or more moieties that result in the targeted depletion of T cells expressing the MS-associated TCRs. Other agents such as the MS-associated TCRs or binding domains thereof, and inhibitory immune cells expressing such TCRs are also provided. Aspects of the present disclosure further include methods of treating multiple sclerosis in a subject in need thereof via administration of an agent of the present disclosure.

Abstract: The present invention is directed to a multipurpose device that can be alternately configured to form a blanket, a cushion, a hooded poncho, a hooded poncho with a fastening shawl, and a tote bag. The multipurpose device includes a pliable sheet that can be configured for use as a blanket. The pliable sheet is lengthwise dividable into three sections, a first one-third section, a second one-third section having a middle and a third one-third section. The multipurpose device also contains a first attachment. The first attachment includes at least a bi-layer of material that form a first and second pocket and is attached to the pliable sheet near a first edge of the second one third section. The pliable sheet can be folded, preferably with the assistance of specifically placed securing devices, into the second pocket to form the cushion configuration.