Patents by Inventor Amanda Smith
Amanda Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250153204Abstract: A device for fluidizing and delivering a powdered agent, including a canister extending longitudinally from a first to a second end and defining a space within which a powdered agent is received, an inlet coupleable to a gas source for supplying gas to the space to fluidize the powdered agent to create a fluidized mixture, an outlet via which the gas mixture is delivered to a target area, a tube extending from the outlet into the interior space, the tube including a slot extending through a wall thereof so that gas mixture is passable from the interior space through the outlet via the second end and the slot, and a door movably coupled to the tube so that the door is movable over the slot to control a size of the slot open to the interior space of the canister.Type: ApplicationFiled: January 14, 2025Publication date: May 15, 2025Applicant: Boston Scientific Scimed, Inc.Inventors: Andrew PIC, Joseph KING, Amanda SMITH, Jessica GRIMSBY, John FAVREAU, Lauren LYDECKER
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Publication number: 20250152150Abstract: Systems and methods of delivering a patch to a target site of a patient are described herein. The patch may comprise a biomaterial such as chitosan or extracellular matrix and may be biocompatible and/or bioresorbable. The system may include an endoscope, a patch, and one of an instrument or a cap, the patch being coupled to the respective instrument or cap and detachable therefrom. Methods of delivering the patch to the target site may include introducing an endoscope into a gastrointestinal tract of a patient, e.g., the patch being in a folded or crimped configuration, navigating a distal end of the endoscope proximate a target site; and applying the patch to the target site while releasing the patch from the endoscope.Type: ApplicationFiled: January 16, 2025Publication date: May 15, 2025Applicant: Boston Scientific Scimed, Inc.Inventors: Amanda SMITH, Andrew PIC, Hannah REBAR
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Publication number: 20250114339Abstract: Provided herein are methods of treating cancer by administering a combination therapy comprising a KRAS G12D inhibitor and an EGFR inhibitor.Type: ApplicationFiled: October 8, 2024Publication date: April 10, 2025Inventors: Matthew Farren, Alexandra Gallion, Sunkyu Kim, Valerie Roman, Amanda Smith, Renee Wallower, Hui Wang
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Publication number: 20250114346Abstract: Provided herein are methods of treating cancer by administering a combination therapy comprising a KRAS G12D inhibitor and a PD-1 inhibitor or a PD-L1 inhibitor.Type: ApplicationFiled: October 8, 2024Publication date: April 10, 2025Inventors: Matthew Farren, Alexandra Gallion, Sunkyu Kim, Valerie Roman, Amanda Smith, Renee Wallower, Hui Wang
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Publication number: 20250090814Abstract: A medical device includes a sheath having a proximal end, a distal end, and at least one lumen extending from the proximal end to the distal end, and a balloon at the distal end of the sheath and having an inflated configuration and a deflated configuration. The balloon defines at least one space radially inward of an exterior surface of the balloon, the at least one space configured to retain a material, and the transition of the balloon from the deflated configuration to the inflated configuration delivers the material from the at least one space to a target site in a body.Type: ApplicationFiled: December 5, 2024Publication date: March 20, 2025Applicant: Boston Scientific Scimed, Inc.Inventors: Amanda SMITH, Jennifer MAGUE, Lauren LYDECKER, Andrew PIC
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Patent number: 12232712Abstract: Systems and methods of delivering a patch to a target site of a patient are described herein. The patch may comprise a biomaterial such as chitosan or extracellular matrix and may be biocompatible and/or bioresorbable. The system may include an endoscope, a patch, and one of an instrument or a cap, the patch being coupled to the respective instrument or cap and detachable therefrom. Methods of delivering the patch to the target site may include introducing an endoscope into a gastrointestinal tract of a patient, e.g., the patch being in a folded or crimped configuration, navigating a distal end of the endoscope proximate a target site; and applying the patch to the target site while releasing the patch from the endoscope.Type: GrantFiled: August 3, 2022Date of Patent: February 25, 2025Assignee: Boston Scientific Scimed, Inc.Inventors: Amanda Smith, Andrew Pic, Hannah Rebar
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Patent number: 12226793Abstract: A device for fluidizing and delivering a powdered agent, including a canister extending longitudinally from a first to a second end and defining a space within which a powdered agent is received, an inlet coupleable to a gas source for supplying gas to the space to fluidize the powdered agent to create a fluidized mixture, an outlet via which the gas mixture is delivered to a target area, a tube extending from the outlet into the interior space, the tube including a slot extending through a wall thereof so that gas mixture is passable from the interior space through the outlet via the second end and the slot, and a door movably coupled to the tube so that the door is movable over the slot to control a size of the slot open to the interior space of the canister.Type: GrantFiled: October 30, 2023Date of Patent: February 18, 2025Assignee: Boston Scientific Scimed, Inc.Inventors: Andrew Pic, Joseph King, Amanda Smith, Jessica Grimsby, John Favreau, Lauren Lydecker
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Patent number: 12186506Abstract: A medical device includes a sheath having a proximal end, a distal end, and at least one lumen extending from the proximal end to the distal end, and a balloon at the distal end of the sheath and having an inflated configuration and a deflated configuration. The balloon defines at least one space radially inward of an exterior surface of the balloon, the at least one space configured to retain a material, and the transition of the balloon from the deflated configuration to the inflated configuration delivers the material from the at least one space to a target site in a body.Type: GrantFiled: November 24, 2020Date of Patent: January 7, 2025Assignee: Boston Scientific Scimed, Inc.Inventors: Amanda Smith, Jennifer Mague, Lauren Lydecker, Andrew Pic
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Patent number: 12048822Abstract: Implementations of a delivery device and method are disclosed. One implementation is a delivery device comprising a flow chamber with an inlet port for receiving a fluid flow in the flow chamber, and an outlet port for exiting a material from the flow chamber. The flow chamber may include a formation portion in which a suspension of the material is formed, and a collection portion that directs the suspension toward and/or into the outlet port. An amount of the material may collect in the collection portion adjacent the outlet port. The device may further comprise an insertion port for permitting insertion of the material in the flow chamber, and/or a pusher operable to move the amount of material through the outlet port. Related devices and methods also are disclosed.Type: GrantFiled: August 9, 2022Date of Patent: July 30, 2024Assignee: Boston Scientific Scimed, Inc.Inventors: Laura Christakis, Ashleigh Peterson, Jeffrey Bean, Claude Clerc, Andrew Pic, Gerald Fredrickson, Stan Gilbert, Amanda Smith, Jose Vega
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Publication number: 20240067954Abstract: The present invention relates to an RNA-mediated base editing system that enables recruitment of multiple effector proteins to a single target site, allowing for highly efficient base editing. The invention further relates to methods and kits for genetically modifying a cell.Type: ApplicationFiled: January 5, 2022Publication date: February 29, 2024Inventors: John Lambourne, Immacolata Porreca, Amanda Smith
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Publication number: 20240067983Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.Type: ApplicationFiled: January 5, 2022Publication date: February 29, 2024Inventors: Kurt Daniel Marshall, Hide Bueno Machado, Emily Anderson, Alexander Hale, Amanda Smith, Anastasia Kaufman, Leah Nantie, Michael Daniel Rushton, Kevin Hemphill
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Publication number: 20240060088Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.Type: ApplicationFiled: January 5, 2022Publication date: February 22, 2024Inventors: Hide Bueno Machado, Kevin Hemphill, Robert Blassberg, Amanda Smith, Michael Daniel Rushton, Pablo Perez-Duran
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Publication number: 20240050968Abstract: A device for fluidizing and delivering a powdered agent, including a canister extending longitudinally from a first to a second end and defining a space within which a powdered agent is received, an inlet coupleable to a gas source for supplying gas to the space to fluidize the powdered agent to create a fluidized mixture, an outlet via which the gas mixture is delivered to a target area, a tube extending from the outlet into the interior space, the tube including a slot extending through a wall thereof so that gas mixture is passable from the interior space through the outlet via the second end and the slot, and a door movably coupled to the tube so that the door is movable over the slot to control a size of the slot open to the interior space of the canister.Type: ApplicationFiled: October 30, 2023Publication date: February 15, 2024Applicant: Boston Scientific Scimed, Inc.Inventors: Andrew PIC, Joseph KING, Amanda SMITH, Jessica GRIMSBY, John FAVREAU, Lauren LYDECKER
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Patent number: 11833539Abstract: A device for fluidizing and delivering a powdered agent, including a canister extending longitudinally from a first to a second end and defining a space within which a powdered agent is received, an inlet coupleable to a gas source for supplying gas to the space to fluidize the powdered agent to create a fluidized mixture, an outlet via which the gas mixture is delivered to a target area, a tube extending from the outlet into the interior space, the tube including a slot extending through a wall thereof so that gas mixture is passable from the interior space through the outlet via the second end and the slot, and a door movably coupled to the tube so that the door is movable over the slot to control a size of the slot open to the interior space of the canister.Type: GrantFiled: October 1, 2019Date of Patent: December 5, 2023Assignee: Boston Scientific Scimed, Inc.Inventors: Andrew Pic, Joseph King, Amanda Smith, Jessica Grimsby, John Favreau, Lauren Lydecker
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Patent number: 11654040Abstract: A neck stabilizing device for supporting a user's neck in vertical extension, includes a harness configured to be worn on a user's torso and a neck bracing member having an elongated stem for attachment to the harness, and a support portion configured to contact the base of the user's skull. The neck bracing member is shaped to follow the anterior and posterior curvature of the user's spine, and is flexibly resilient to allow for and resist neck extension.Type: GrantFiled: April 6, 2020Date of Patent: May 23, 2023Assignee: Paintsmith Decor Ltd.Inventor: Amanda Smith
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Publication number: 20220379102Abstract: Implementations of a delivery device and method are disclosed. One implementation is a delivery device comprising a flow chamber with an inlet port for receiving a fluid flow in the flow chamber, and an outlet port for exiting a material from the flow chamber. The flow chamber may include a formation portion in which a suspension of the material is formed, and a collection portion that directs the suspension toward and/or into the outlet port. An amount of the material may collect in the collection portion adjacent the outlet port. The device may further comprise an insertion port for permitting insertion of the material in the flow chamber, and/or a pusher operable to move the amount of material through the outlet port. Related devices and methods also are disclosed.Type: ApplicationFiled: August 9, 2022Publication date: December 1, 2022Applicant: Boston Scientific Scimed, Inc.Inventors: Laura CHRISTAKIS, Ashleigh PETERSON, Jeffrey BEAN, Claude CLERC, Andrew PIC, Gerald FREDRICKSON, Stan GILBERT, Amanda SMITH, Jose VEGA
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Publication number: 20220370059Abstract: Systems and methods of delivering a patch to a target site of a patient are described herein. The patch may comprise a biomaterial such as chitosan or extracellular matrix and may be biocompatible and/or bioresorbable. The system may include an endoscope, a patch, and one of an instrument or a cap, the patch being coupled to the respective instrument or cap and detachable therefrom. Methods of delivering the patch to the target site may include introducing an endoscope into a gastrointestinal tract of a patient, e.g., the patch being in a folded or crimped configuration, navigating a distal end of the endoscope proximate a target site; and applying the patch to the target site while releasing the patch from the endoscope.Type: ApplicationFiled: August 3, 2022Publication date: November 24, 2022Applicant: Boston Scientific Scimed, Inc.Inventors: Amanda SMITH, Andrew PIC, Hannah REBAR
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Patent number: 11439374Abstract: Systems and methods of delivering a patch to a target site of a patient are described herein. The patch may comprise a biomaterial such as chitosan or extracellular matrix and may be biocompatible and/or bioresorbable. The system may include an endoscope, a patch, and one of an instrument or a cap, the patch being coupled to the respective instrument or cap and detachable therefrom. Methods of delivering the patch to the target site may include introducing an endoscope into a gastrointestinal tract of a patient, e.g., the patch being in a folded or crimped configuration, navigating a distal end of the endoscope proximate a target site; and applying the patch to the target site while releasing the patch from the endoscope.Type: GrantFiled: July 30, 2019Date of Patent: September 13, 2022Assignee: Boston Scientific Scimed, Inc.Inventors: Amanda Smith, Andrew Pic, Hannah Rebar
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Patent number: 11433223Abstract: Implementations of a delivery device and method are disclosed. One implementation is a delivery device comprising a flow chamber with an inlet port for receiving a fluid flow in the flow chamber, and an outlet port for exiting a material from the flow chamber. The flow chamber may include a formation portion in which a suspension of the material is formed, and a collection portion that directs the suspension toward and/or into the outlet port. An amount of the material may collect in the collection portion adjacent the outlet port. The device may further comprise an insertion port for permitting insertion of the material in the flow chamber, and/or a pusher operable to move the amount of material through the outlet port. Related devices and methods also are disclosed.Type: GrantFiled: September 4, 2019Date of Patent: September 6, 2022Assignee: Boston Scientific Scimed, Inc.Inventors: Laura Christakis, Ashleigh Peterson, Jeffrey Bean, Claude Clerc, Andrew Pic, Gerald Fredrickson, Stan Gilbert, Amanda Smith, Jose Vega
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Publication number: 20220108252Abstract: In non-limiting examples of the present disclosure, systems, methods and devices for generating sustainability insights and recommendations are presented. An asset disposition service may maintain a library comprising a plurality of software objects. Each of the software objects may correspond to a hardware computing asset and each software object may have a plurality of attributes associated with it related to the physical makeup of the asset, the software executed by the asset, regulatory issues associated with the asset, or contractual terms associated with the asset. The asset disposition service may apply various algorithms and/or machine learning models to one or more attributes of the software objects to generate sustainability insights and recommendations that can be utilized to identify best disposition paths for assets and for meeting sustainability goals.Type: ApplicationFiled: October 2, 2020Publication date: April 7, 2022Inventors: Anand NARASIMHAN, Paul CLARK, Kesava VISWANATHAN, David BEYER, Ranganathan SRIKANTH, Michael Warren ELLIS, Lorraine Elizabeth TEW, Robin Amanda SMITH