Patents by Inventor Amanda Sparkes

Amanda Sparkes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BISPECIFIC CONSTRUCTS FOR EXPANDING T CELLS AND RELATED METHODS
    Publication number: 20230357441
    Abstract: Described herein is a bispecific scFv construct agonizing both CD3 and CD28 pathways. Typically, the construct is soluble and activates, expands, and differentiates human T cells ex vivo. Related compositions and methods are also described, such as methods for expanding, activating, and or differentiating T cells ex vivo and methods of treating cancer.
    Type: Application
    Filed: October 14, 2021
    Publication date: November 9, 2023
    Inventors: Jean GARIEPY, Amanda SPARKES, Esther MATUS, Aaron PRODEUS
  • Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
    Patent number: 11098113
    Abstract: The present invention relates to immunoglobulin single variable domains that bind MIF and more in particular to polypeptides that comprise or essentially consist of one or more such immunoglobulin single variable domains; to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: August 24, 2021
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Peter Vanlandschoot, Ines Cabrito, Benoît Stijlemans, Amanda Sparkes, Jo Van Ginderachter, Patrick De Baetselier
  • IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS DIRECTED AGAINST MACROPHAGE MIGRATION INHIBITORY FACTOR
    Publication number: 20190309056
    Abstract: The present invention relates to immunoglobulin single variable domains that bind MIF and more in particular to polypeptides that comprise or essentially consist of one or more such immunoglobulin single variable domains; to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
    Type: Application
    Filed: September 15, 2017
    Publication date: October 10, 2019
    Applicants: VIB VZW, Vrije Universiteit Brussel
    Inventors: Peter Vanlandschoot, Ines Cabrito, Benoît Stijlemans, Amanda Sparkes, Jo Van Ginderachter, Patrick De Baetselier