Patents by Inventor Amanda Sparkes

Amanda Sparkes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES, ANTIBODY CONSTRUCTS, METHODS AND USES THEREOF
    Publication number: 20260176582
    Abstract: Antibodies are provided herein. In aspects, the antibody is capable of binding to a gastrointestinal tract (GI) tract expressed antigen. In binding to the GI tract expressed antigen, in aspects, the antibody is capable of targeting the antibody to the GI tract and in other aspects, the antibody is capable of expanding T cells. In other aspects, constructs comprising the antibody and cargo are provided. In aspects, Methods and uses are also provided.
    Type: Application
    Filed: November 10, 2025
    Publication date: June 25, 2026
    Inventors: Jean GARIEPY, Amanda SPARKES, Esther MATUS
  • CONSTRUCTS, USE AND METHODS THEREOF
    Publication number: 20240309052
    Abstract: A construct is provided. The construct comprises poliovirus receptor and a Fc domain. In aspects, the PVR is a truncated PVR. Uses of the construct for reducing inflammatory diseases or conditions, reducing symptoms associated with inflammatory diseases or conditions, or reducing immune responses, and associated methods are also provided.
    Type: Application
    Filed: March 15, 2024
    Publication date: September 19, 2024
    Inventors: Jean Gariepy, Shrayasee Saha, Amanda Sparkes
  • VISTA AGONISTS AND RELATED COMPOSITIONS AND METHODS
    Publication number: 20240293499
    Abstract: Described herein is a VISTA agonist for inhibiting an immune response, wherein the VISTA agonist causes at least one of the following: an increase in IL-10 expression; a decrease in proliferation of CD4+ T cells; a decrease in proliferation of CD8+ T cells; a decrease in IL-2 expression; a decrease in IFN-? expression; and a decrease in IL-17 expression.
    Type: Application
    Filed: June 24, 2022
    Publication date: September 5, 2024
    Inventors: Jean Gariepy, Vivian Ma, Amanda Sparkes, Esther Matus
  • BISPECIFIC CONSTRUCTS FOR EXPANDING T CELLS AND RELATED METHODS
    Publication number: 20230357441
    Abstract: Described herein is a bispecific scFv construct agonizing both CD3 and CD28 pathways. Typically, the construct is soluble and activates, expands, and differentiates human T cells ex vivo. Related compositions and methods are also described, such as methods for expanding, activating, and or differentiating T cells ex vivo and methods of treating cancer.
    Type: Application
    Filed: October 14, 2021
    Publication date: November 9, 2023
    Inventors: Jean GARIEPY, Amanda SPARKES, Esther MATUS, Aaron PRODEUS
  • Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
    Patent number: 11098113
    Abstract: The present invention relates to immunoglobulin single variable domains that bind MIF and more in particular to polypeptides that comprise or essentially consist of one or more such immunoglobulin single variable domains; to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: August 24, 2021
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Peter Vanlandschoot, Ines Cabrito, Benoît Stijlemans, Amanda Sparkes, Jo Van Ginderachter, Patrick De Baetselier
  • IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS DIRECTED AGAINST MACROPHAGE MIGRATION INHIBITORY FACTOR
    Publication number: 20190309056
    Abstract: The present invention relates to immunoglobulin single variable domains that bind MIF and more in particular to polypeptides that comprise or essentially consist of one or more such immunoglobulin single variable domains; to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes.
    Type: Application
    Filed: September 15, 2017
    Publication date: October 10, 2019
    Applicants: VIB VZW, Vrije Universiteit Brussel
    Inventors: Peter Vanlandschoot, Ines Cabrito, Benoît Stijlemans, Amanda Sparkes, Jo Van Ginderachter, Patrick De Baetselier