Abstract: Radiation sealing assemblies and methods of use of a radiation containment component for sealing a microcatheter used to deliver a mixed particulate from a particulate delivery device for disposal, which may include a proximal end and a distal end disposed opposite the proximal end. The proximal end is configured to connect to and cover a distal portion of a delivery line connector of the particulate delivery device, the delivery line connector configured to receive the mixed particulate from the particulate delivery device. The distal end is configured to be disposed over and contain the microcatheter connected to the delivery line connector after use, and the distal end is configured to seal together to contain the microcatheter prior to disposal.

Abstract: A vial assembly includes a vial and a needle with at least one port. The vial includes a particulate material, a septum, a neck region including a first width, and a particulate region including a second width greater than the first width. The vial assembly is configured to move to a locked position. The needle may be configured to puncture the septum with the at least one port configured to be in the neck region when in the locked position. The at least one port may be configured to inject a fluid into the vial assembly to mix with the particulate material upon actuation of a vial engagement mechanism in a first direction and to receive a resulting mixed fluid from the vial assembly upon actuation of the vial engagement mechanism in a second direction opposite the first direction.

Abstract: A septum for sealing a vial assembly having a vial including a neck region including a first width comprises a top surface, a bottom surface disposed opposite the top surface, a radially extending outer side surface disposed between the top surface and the bottom surface, a plurality of ribs disposed on the top surface, and a plurality of valleys. Each valley may be disposed between to space apart at least two ribs of the plurality of ribs. The plurality of ribs may include at least an interior first rib, an intermediate rib, and an exterior outer rib. The interior first rib may include an outer wall, the outer wall configured to radially compress against an interior wall of the neck region of the vial, the outer wall including a height that is greater than a height of the intermediate rib and the exterior outer rib.

Abstract: Systems and methods involve a vial assembly system comprising a vial assembly and needle. The vial assembly comprises a septum, neck region, and particulate region comprising a bypass valve, the neck region comprising a top, bottom, and sidewall. The needle comprises a port and a tip configured to puncture the septum that is configured to receive the needle such that the port is disposed in the neck region. A bypass path includes a first end and a second end, the bypass valve is connected to the first end, the second end ends at or within the sidewall, the bypass path is configured to provide a fluid flow path to the needle alternate to a first path upon a build-up of pressure for fluid flow in the vial assembly, and the first path is directly disposed in the vial assembly between the particulate region and the neck region.

Abstract: A vial assembly includes a vial and a needle with at least one port. The vial includes a particulate material, a septum, a neck region including a first width, and a particulate region including a second width greater than the first width. The vial assembly is configured to move to a locked position. The needle may be configured to puncture the septum with the at least one port configured to be in the neck region when in the locked position. The at least one port may be configured to inject a fluid into the vial assembly to mix with the particulate material upon actuation of a vial engagement mechanism in a first direction and to receive a resulting mixed fluid from the vial assembly upon actuation of the vial engagement mechanism in a second direction opposite the first direction.

Abstract: A delivery assembly includes a console including a vial containment region and a vial engagement mechanism extending from the console within the vial containment region. The engagement mechanism is configured to engage a vial assembly including a particulate material. The delivery assembly further includes a multi-port needle with a top distal port and bottom proximal port(s), the needle configured to puncture a septum of the vial assembly when the vial assembly is in the locked position, in which the top distal port is at a distance above the particulate material in the vial assembly. The ports are configured to inject a fluid into the vial assembly to mix with the particulate material upon actuation of the vial engagement mechanism in a first direction and to receive a resulting mixed fluid from the vial assembly upon actuation of the vial engagement mechanism in a second opposite direction.