Abstract: A system and method is provided for imaging a region of interest (“ROI”) including a breast having received a reduced dose of radionuclide using an imaging system including at least two gamma detectors. The acquired imaging data is analyzed respect to an energy characteristic and divided into subsets of data based on the analysis. A plurality of images is generated using the subsets of data, wherein the plurality of images include a primary image corresponding to subsets of data having energy including the energy characteristic and multiple secondary images corresponding to subsets of data having energy not including the energy characteristic. Each of the plurality of images is processed using energy information associated with each of the plurality of images and the processed plurality of images is combined to form a composite image of the ROI.