Patents by Inventor Amani Makkouk

Amani Makkouk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Arginase inhibitor combination therapies
    Patent number: 11291674
    Abstract: The disclosure relates to methods of treating or preventing a disease in a subject by conjointly administering to the subject an arginase inhibitor disclosed herein and a composition comprising immune cells disclosed herein.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: April 5, 2022
    Assignee: CALITHERA BIOSCIENCES, INC.
    Inventors: Amani Makkouk, Matthew I. Gross, Francesco Parlati
  • Methods for treating tumors in situ including intratumor injection of cytotoxic particles and immune checkpoint blockade therapy
    Patent number: 10314854
    Abstract: Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. The compositions, kits, and methods comprise or utilize cytotoxic particles, immune checkpoint inhibitors, and/or T-cell stimulatory agents.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: June 11, 2019
    Assignee: University of Iowa Foundation
    Inventors: Aliasger K. Salem, Amani Makkouk, Vijaya B. Joshi, George Weiner
  • ARGINASE INHIBITOR COMBINATION THERAPIES
    Publication number: 20180161349
    Abstract: The disclosure relates to methods of treating or preventing a disease in a subject by conjointly administering to the subject an arginase inhibitor disclosed herein and a composition comprising immune cells disclosed herein.
    Type: Application
    Filed: November 8, 2017
    Publication date: June 14, 2018
    Inventors: Amani MAKKOUK, Matthew I. GROSS, Francesco PARLATI
  • METHODS FOR TREATING TUMORS IN SITU INCLUDING INTRATUMOR INJECTION OF CYTOTOXIC PARTICLES AND IMMUNE CHECKPOINT BLOCKADE THERAPY
    Publication number: 20180147224
    Abstract: Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. The compositions, kits, and methods comprise or utilize cytotoxic particles, immune checkpoint inhibitors, and/or T-cell stimulatory agents.
    Type: Application
    Filed: May 16, 2016
    Publication date: May 31, 2018
    Applicant: University of Iowa Research Foundation
    Inventors: Aliasger K. Salem, Amani Makkouk, Vijaya B. Joshi, George Weiner