Abstract: A tissue box holder that has a substantially similar shape of commercially available tissue box is described. In one embodiment, the holder is substantially slab-shaped with two opposing side faces, a front flap that can be opened and/or closed, a rear edge face, a bottom face with at least one attach means and a top face with an open slot that allows tissues to be retrieved or pulled out sequentially. The holder is made of sturdy material such as plastics, leathers, or the likes. The holder can be attached to a number of different surfaces such as interior surfaces of a vehicle, a wheel chair, and an office of doctor's office. The open slot is designed such that the tissue box can be inserted after the tissue box has already opened with tissues sticking out.