Patents by Inventor Amar GHISAIDOOBE

Amar GHISAIDOOBE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-(5-((aryl or heteroaryl)methyloxy)pentyl)-substituted iminosugars as inhibitors of glucosylceramide synthase
    Patent number: 10590082
    Abstract: Deoxynojirimycin and deoxygalactonojirimycin derivatives according to the present invention are N-alkylated D-galacto, D-gluco- or L-ido-deoxynojirimycin with a linear methyloxypentyl group bearing various sidegroups and a non-fused bicyclic aromatic group (“X”) on the methyloxy-carbon. Formula (I), Formula (Ia). These compounds display an increased inhibitory potency towards GCS, and/or an increased inhibitory potency towards GBA2, and/or a decreased inhibitory potency towards GBA1, relative to known deoxynojirimycin derivatives of the same (D-gluco, L-ido or D-galacto) configuration.
    Type: Grant
    Filed: January 7, 2019
    Date of Patent: March 17, 2020
    Assignees: Academisch Medisch Centrum, Universiteit Leiden
    Inventors: Herman Steven Overkleeft, Stan Van Boeckel, Johannes Maria Franciscus Gerardus Aerts, Amar Ghisaidoobe, Richard Van Den Berg
  • N-(5-((ARYL OR HETEROARYL)METHYLOXY)PENTYL)-SUBSTITUTED IMINOSUGARS AS INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE
    Publication number: 20190144388
    Abstract: Deoxynojirimycin and deoxygalactonojirimycin derivatives according to the present invention are N-alkylated D-galacto, D-gluco- or L-ido-deoxynojirimycin with a linear methyloxypentyl group bearing various sidegroups and a non-fused bicyclic aromatic group (“X”) on the methyloxy-carbon. Formula (I), Formula (Ia). These compounds display an increased inhibitory potency towards GCS, and/or an increased inhibitory potency towards GBA2, and/or a decreased inhibitory potency towards GBA1, relative to known deoxynojirimycin derivatives of the same (D-gluco, L-ido or D-galacto) configuration.
    Type: Application
    Filed: January 7, 2019
    Publication date: May 16, 2019
    Inventors: Herman Steven OVERKLEEFT, Stan VAN BOECKEL, Johannes Maria Franciscus Gerardus AERTS, Amar GHISAIDOOBE, Richard VAN DEN BERG
  • N-(5-((aryl or heteroaryl)methyloxy)pentyl)-substituted iminosugars as inhibitors of glucosylceramide synthase
    Patent number: 10189784
    Abstract: Deoxynojirimycin and deoxygalactonojirimycin derivatives according to the present invention are N-alkylated D-galacto, D-gluco- or L-ido-deoxynojirimycin with a linear methyloxypentyl group bearing various sidegroups and a non-fused bicyclic aromatic group (“X”) on the methyloxy-carbon. These compounds display an increased inhibitory potency towards GCS, and/or an increased inhibitory potency towards GBA2, and/or a decreased inhibitory potency towards GBA1, relative to known deoxynojirimycin derivatives of the same (D-gluco, L-ido or D-galacto) configuration.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: January 29, 2019
    Assignees: ACADEMISCH MEDISCH CENTRUM, UNIVERSITEIT LEIDEN
    Inventors: Herman Steven Overkleeft, Stan Van Boeckel, Johannes Maria Franciscus Gerardus Aerts, Amar Ghisaidoobe, Richard Van Den Berg
  • N-(5-((ARYL OR HETEROARYL)METHYLOXY)PENTYL)-SUBSTITUTED IMINOSUGARS AS INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE
    Publication number: 20170226058
    Abstract: Deoxynojirimycin and deoxygalactonojirimycin derivatives according to the present invention are N-alkylated D-galacto, D-gluco- or L-ido-deoxynojirimycin with a linear methyloxypentyl group bearing various sidegroups and a non-fused bicyclic aromatic group (“X”) on the methyloxy-carbon. These compounds display an increased inhibitory potency towards GCS, and/or an increased inhibitory potency towards GBA2, and/or a decreased inhibitory potency towards GBA1, relative to known deoxynojirimycin derivatives of the same (D-gluco, L-ido or D-galacto) configuration.
    Type: Application
    Filed: March 23, 2015
    Publication date: August 10, 2017
    Inventors: Herman Steven OVERKLEEFT, Stan VAN BOECKEL, Johannes Maria Franciscus Gerardus AERTS, Amar GHISAIDOOBE, Richard VAN DEN BERG