Abstract: The present invention relates to a compound for use as a medicament in the treatment or prevention of acute liver failure, which acute liver failure is induced by intoxication prior to or following administration of the compound. Accordingly, the invention relates to the compound for use in the treatment of an intoxication that without treatment is expected to result in acute liver failure or that without treatment is sufficient to induce acute liver failure. The invention also provides the compound for use in the treatment, and a corresponding method for the treatment of an intoxication sufficient to induce acute liver failure.

Abstract: The present invention relates to a compound for use as a medicament in the treatment or prevention of acute liver failure, which acute liver failure is induced by intoxication prior to or following administration of the compound. Accordingly, the invention relates to the compound for use in the treatment of an intoxication that without treatment is expected to result in acute liver failure or that without treatment is sufficient to induce acute liver failure. The invention also provides the compound for use in the treatment, and a corresponding method for the treatment of an intoxication sufficient to induce acute liver failure.

Abstract: Systems, methods, and apparatus are disclosed for reserving items of merchandise for in store pickup and/or inspection. In some embodiments, a reservation method for a store includes receiving, from a first computing device associated with a customer, a request to reserve a requested item for the customer. The reservation method may further include identifying, based on the requested item, an additional item to reserve for the customer. The reservation method may also include sending, to a second computing device associated with an employee of the store, a notification that instructs the employee to gather the requested item and the additional item and place the gathered items in a reserved merchandise area of the store.

Abstract: Systems, methods, and apparatus are disclosed for reserving items of merchandise for in store pickup and/or inspection. In some embodiments, a reservation method for a store includes receiving, from a first computing device associated with a customer, a request to reserve a requested item for the customer. The reservation method may further include identifying, based on the requested item, an additional item to reserve for the customer. The reservation method may also include sending, to a second computing device associated with an employee of the store, a notification that instructs the employee to gather the requested item and the additional item and place the gathered items in a reserved merchandise area of the store.

Abstract: Small inhibitory RNA (siRNA) molecules, which e.g. are purified and/or isolated, as an active in a medicament, which siRNA molecules are inhibitory RNA molecules that through RNA interference (RNAi) reduce or prevent expression of the p53 upregulated modulator of apoptosis (PUMA). The siRNA molecules can be administered as a medicament to a patient suffering from an impaired liver function or from liver damage for the treatment of a functionally impaired liver, for delaying a deterioration of liver function and/or for prevention of liver failure, especially in patients who suffer from a critical impairment of damage to the liver, e.g. for delaying the complete failure of liver function.