Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

Abstract: The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).

Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

Abstract: Methods for tracking and managing a device that connects to a database system, including connecting to a web application at least partially running on the database system, are disclosed. In some embodiments, the device may be identified by a fingerprint or unique device identifier (ID) formed from various vectors that correspond to device specific attributes or characteristics. The fingerprint or unique device ID may be compared to a fingerprint or device ID stored on the database system associated with a user's access credentials to determine a match percentage. Further access by the device to the database system may depend upon whether the match percentage exceeds a predetermined threshold. Device access to the database system may be tied to the fingerprint or unique device ID.

Abstract: Application security assessment is described. A system identifies a first security configuration and a second security configuration associated with an application. The system calculates a security score based on a comparison of the first security configuration to a first baseline security setting and a comparison of the second security configuration to a second baseline security setting. The system generates a security report associated with the application that includes the security score and outputs the security report.

Abstract: Methods for tracking and managing a device that connects to a database system, including connecting to a web application at least partially running on the database system, are disclosed. In some embodiments, the device may be identified by a fingerprint or unique device ID formed from various vectors that correspond to device specific attributes or characteristics. The fingerprint or unique device ID may be compared to a fingerprint or device ID stored on the database system associated with a user's access credentials to determine a match percentage. Further access by the device to the database system may depend upon whether the match percentage exceeds a predetermined threshold. Device access to the database system may be tied to the fingerprint or unique device ID.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a swellable composition located in an immediate vicinity of one or more preselected surfaces. The coating comprises a defect wherein said defect is not a passageway through the preselected portion of the coating and operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: Application security assessment is described. A system identifies a first security configuration and a second security configuration associated with an application. The system calculates a security score based on a comparison of the first security configuration to a first baseline security setting and a comparison of the second security configuration to a second baseline security setting. The system generates a security report associated with the application that includes the security score and outputs the security report.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a swellable composition located in an immediate vicinity of one or more preselected surfaces. The coating comprises a defect wherein said defect is not a passageway through the preselected portion of the coating and operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating comprising water insoluble polymer(s) and leachable component(s) is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: A normalization engine and a method of requesting a key or performing an operation pertaining to an end point. In one embodiment, the normalization engine includes: (1) a data manager configured to receive a request to execute an operation or obtain a key/value pair pertaining to an end point and determine a normalized version of the key in the key/value pair and (2) a normalization mapping repository configured to contain normalization mechanisms, the data manager further configured to employ the normalized version to obtain one of the normalization mechanisms from the normalization mapping repository, carry out the normalization mechanism and employ a data source corresponding to the end point to retrieve a device-specific value corresponding to the normalized version.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: The present invention is concerned with a system for spatially and temporally programmable delivery of an active agent. When administered orally, the System can be retained in the gastric region for a prolonged period of time. It comprises of a core (I), one or more layers (II, IV, V) coated over the core and a preformed hollow space (III). The invention also concerns with a process for preparation of the System and a method for treating/preventing diseases, by administering to a subject in need thereof, the System of the invention.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: Cloud database is a single integrated universal database for enterprises, which provides a single database for online analytical processing (OLAP) and online transaction processing (OLTP) capabilities on the same database which stores real data. Cloud Database (cDB) can use any column oriented distributed database hosted on cluster of distributed file system to store the data into files. cDB uses divide and conquer principle to process the analytical queries. cDB hosts databases for various application which uses different database of different vendors. cDB adapter is interface between the enterprise application and cDB and handles query processing for the application.

Abstract: The invention relates to a new system and method for process automation system that allows the conversion of a narrowband consumer Internet user into a broadband (e.g., DSL, ISDN, or Data over Cable) Internet user. In an alternative embodiment, the new system and method is used to configure an original broadband connection. The system includes automation agent software residing on the personal computer that is being configured for broadband communication, and an automation server associated with the manager of the broadband network. The automation agent software guides the user through the steps of testing and ordering the service, automates the configuring of the personal computer for broadband communication, and communicates with the automation server to complete the registration, billing and other administrative processes.

Abstract: A method and apparatus for remotely installing and executing software on a mobile device. A work item is formed that includes the software to be installed and executed, and a remote-execution command message is sent to the mobile device. The mobile device authenticates the remote-execution command message before extracting the remote-execution command and using it to request a download of the work item. The remote-execution command message is preferably an SMS message including a hook so that it is quickly recognizable as a remote-execution command message by the mobile device. When the work item arrives, it is authenticated before it is executed. When the mobile device determines that the execution is complete, it sends a notification to the remote-execution server.

Abstract: A method, system, computer system and computer program product to distribute data to arbitrarily large subsets of a very large client base, with each client computer system running client software referred to as an agent. The data distribution system uses minimal server resources and a large-scale network such as the Internet. The data to be distributed may include, for example, agent software configuration data; agent software programs, plug-ins, and associated data; announcements; and other data that is centrally managed by an administrator. Using this invention, millions of client computer systems, such as computer systems for subscribers to a broadband service, can be configured and managed centrally, while allowing data to be distributed to all or a subset of subscribers efficiently and using minimal bandwidth. Agents assist in determining whether particular data are to be distributed to them, enabling much larger-scale applications to be supported with limited server-side resources.