Abstract: The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).

Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

Abstract: Methods for tracking and managing a device that connects to a database system, including connecting to a web application at least partially running on the database system, are disclosed. In some embodiments, the device may be identified by a fingerprint or unique device identifier (ID) formed from various vectors that correspond to device specific attributes or characteristics. The fingerprint or unique device ID may be compared to a fingerprint or device ID stored on the database system associated with a user's access credentials to determine a match percentage. Further access by the device to the database system may depend upon whether the match percentage exceeds a predetermined threshold. Device access to the database system may be tied to the fingerprint or unique device ID.

Abstract: Application security assessment is described. A system identifies a first security configuration and a second security configuration associated with an application. The system calculates a security score based on a comparison of the first security configuration to a first baseline security setting and a comparison of the second security configuration to a second baseline security setting. The system generates a security report associated with the application that includes the security score and outputs the security report.

Abstract: Methods for tracking and managing a device that connects to a database system, including connecting to a web application at least partially running on the database system, are disclosed. In some embodiments, the device may be identified by a fingerprint or unique device ID formed from various vectors that correspond to device specific attributes or characteristics. The fingerprint or unique device ID may be compared to a fingerprint or device ID stored on the database system associated with a user's access credentials to determine a match percentage. Further access by the device to the database system may depend upon whether the match percentage exceeds a predetermined threshold. Device access to the database system may be tied to the fingerprint or unique device ID.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a swellable composition located in an immediate vicinity of one or more preselected surfaces. The coating comprises a defect wherein said defect is not a passageway through the preselected portion of the coating and operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: Application security assessment is described. A system identifies a first security configuration and a second security configuration associated with an application. The system calculates a security score based on a comparison of the first security configuration to a first baseline security setting and a comparison of the second security configuration to a second baseline security setting. The system generates a security report associated with the application that includes the security score and outputs the security report.

Abstract: This process describes method to recover over 95 percent recovery of Oil and gas from Shale fracking, Oil Sands, Biomass, and hydrates and from deep water wells by novel invention. The disclosure describes using CO2, H2O2 and some proprietary chemicals, metals, proppants and raising the temperature where in situ Shale fracturing, Oil sands, biomass and gas hydrates and dislodges the gas and oil. Additionally process describes safety devices with pressure reduction at the reservoir in the production well bore upstream of BOP. This process uses no water and produces no waste water.

Abstract: Methods to recover over 95 percent of oil and gas from shale fracturing, oil sands, biomass, and hydrates and from deep water wells. Employing CO2, H2O2, some proprietary chemicals, metals and proppants, raising the temperature of the mixture and using the mixture in shale fracturing, oil sands, biomass and gas hydrates to dislodge the gas and oil. Additionally, safety devices capable of pressure reduction at the reservoir in the production well bore upstream of a BOP are included. No water is used and no waste water is produced.

Abstract: Systems, methods, and computer readable media suited for data recordation in processing at least one insurance claim or financial services transaction. During a predetermined time period, there is received, from a user-accessible device, via a computer communications network, a data entry for addition to a transient data table, with relation to at least one insurance claim or financial services transaction. Further, there is received at least one additional data entry for addition to the transient data table. Via a processor, the data entries are aggregated over the predetermined time period. Further, the aggregated data are frozen and recorded upon expiration of the predetermined time period. Additionally, the aggregated data are outputted for viewing upon expiration of the predetermined time period. Also, there are repeated, at least once and over an additional predetermined time period, the receipt and aggregation of data entries and the freezing, recordation and outputting of aggregated data.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a swellable composition located in an immediate vicinity of one or more preselected surfaces. The coating comprises a defect wherein said defect is not a passageway through the preselected portion of the coating and operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating comprising water insoluble polymer(s) and leachable component(s) is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: A normalization engine and a method of requesting a key or performing an operation pertaining to an end point. In one embodiment, the normalization engine includes: (1) a data manager configured to receive a request to execute an operation or obtain a key/value pair pertaining to an end point and determine a normalized version of the key in the key/value pair and (2) a normalization mapping repository configured to contain normalization mechanisms, the data manager further configured to employ the normalized version to obtain one of the normalization mechanisms from the normalization mapping repository, carry out the normalization mechanism and employ a data source corresponding to the end point to retrieve a device-specific value corresponding to the normalized version.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: The present invention is concerned with a system for spatially and temporally programmable delivery of an active agent. When administered orally, the System can be retained in the gastric region for a prolonged period of time. It comprises of a core (I), one or more layers (II, IV, V) coated over the core and a preformed hollow space (III). The invention also concerns with a process for preparation of the System and a method for treating/preventing diseases, by administering to a subject in need thereof, the System of the invention.

Abstract: An oral drug delivery system comprising a coated tablet having one or more surfaces. The coated tablet further comprises a core and a coating surrounding the core. The core comprises an active ingredient composition comprising at least one active ingredient and a pharmaceutically acceptable excipient and a composition selected from a swellable composition and a reactive composition located in an immediate vicinity of one or more preselected surfaces. The coating is operable to be reliably removed fully from the one or more of the preselected surfaces of the tablet upon contact with an aqueous environment, but not removed from at least one of the surfaces.

Abstract: Cloud database is a single integrated universal database for enterprises, which provides a single database for online analytical processing (OLAP) and online transaction processing (OLTP) capabilities on the same database which stores real data. Cloud Database (cDB) can use any column oriented distributed database hosted on cluster of distributed file system to store the data into files. cDB uses divide and conquer principle to process the analytical queries. cDB hosts databases for various application which uses different database of different vendors. cDB adapter is interface between the enterprise application and cDB and handles query processing for the application.

Abstract: The invention relates to a new system and method for process automation system that allows the conversion of a narrowband consumer Internet user into a broadband (e.g., DSL, ISDN, or Data over Cable) Internet user. In an alternative embodiment, the new system and method is used to configure an original broadband connection. The system includes automation agent software residing on the personal computer that is being configured for broadband communication, and an automation server associated with the manager of the broadband network. The automation agent software guides the user through the steps of testing and ordering the service, automates the configuring of the personal computer for broadband communication, and communicates with the automation server to complete the registration, billing and other administrative processes.

Abstract: A process for selective hydrogenation of C3/C4/C5/C6/C7 and LCN, hydro-isomerization of olefins, benzene saturation and hydrodesulfurization of Gasoline, Kerosene and Diesel together with aromatic saturation of LCO is being provided so as to provide optimum technology at low cost with unique configuration. The technology is user friendly and uses conventional catalyst. These configurations cover both the options of installing the bulk catalyst in the distillation column with chimneys trays, hence essentially all the reaction takes place in the liquid phase in single or multiple beds or with fixed bed down flow or up flow reactor configuration. The configurations shown in the figures depicts that the fixed bed reactors are integrated with the Distillation Column and this art helps in lowering the Capital costs and the reactors are operating in single phase or two-phase conditions.