Abstract: The present invention relates to a cationic lipid based aqueous formulation comprising cationic lipid, dexamethasone and a neutral co-lipid, wherein the said formulation is useful for selective targeting and delivering gene to glucocorticoid receptor expressing cancer cells. Glucorticoid receptors (GR) express in various normal and cancer cells. A lot of ligand activated physiological functions are known involving GR but its role in cancer progression (if any) is not clearly understood. Synthetic GR antagonist, dexamethasone (Dex) finds use as anti-inflammatory drug and is known to induce apoptosis in cancer cells. This Dex is included in a cationic lipid-based formulation as a co-lipid to deliver to and express genes specifically in cancer cells possibly through expressed GR. Gene delivery to cancer cells is independent of the gene construct, and tumor cell line. Normal transformed cells expressing GR but with no cancer lineage show much smaller level of transfection.

Abstract: The present invention relates to a cationic lipid based aqueous formulation comprising cationic lipid, dexamethasone and a neutral co-lipid, wherein the said formulation is useful for selective targeting and delivering gene to glucocorticoid receptor expressing cancer cells. Glucorticoid receptors (GR) express in various normal and cancer cells. A lot of ligand activated physiological functions are known involving GR but its role in cancer progression (if any) is not clearly understood. Synthetic GR antagonist, dexamethasone (Dex) finds use as anti-inflammatory drug and is known to induce apoptosis in cancer cells. This Dex is included in a cationic lipid-based formulation as a co-lipid to deliver to and express genes specifically in cancer cells possibly through expressed GR. Gene delivery to cancer cells is independent of the gene construct, and tumor cell line. Normal transformed cells expressing GR but with no cancer lineage show much smaller level of transfection.

Abstract: A method of automatically extracting knowledge from user generated trails. The method of this invention provides: (a) a collection of trails, each comprising a collection of resources; resources include URLs, documents, computer files, images, database objects, videos, music, emails, or a combination of these; a resource may also be a collection of other resources. Resources and trails may optionally have additional meta-data associated with them. (b) computer programs that identify the following: (b.1) given a trail, resources that are not contained within the trail, but are nevertheless related to the contents of that trail; (b.2) resources that have an affinity to each other (e.g., “similar urls”) regardless of which trails they belong to; (b.3) resources that are dissimilar (e.g., low or negative affinity), regardless of which trails they belong to. The system also lets users search for resources and trails shared by other users, and/or shared with specific groups.

Abstract: Techniques are provided for monitoring a database system. A set of data elements may be read from a database system into a device. The device may be external to the database system. From the device, a set of analysis operations are performed on the data elements in order to identify if any of the date elements satisfy a criteria for being considered potentially anomalous. A notification is signaled if potentially anomalous data is identified.

Abstract: Techniques are provided for monitoring a database system. A set of data elements may be read from a database system into a device. The device may be external to the database system. From the device, a set of analysis operations are performed on the data elements in order to identify if any of the date elements satisfy a criteria for being considered potentially anomalous. A notification is signaled if potentially anomalous data is identified.