Patents by Inventor Amarnath Natarajan

Amarnath Natarajan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dimers of covalent NFKB inhibitors
    Patent number: 11840540
    Abstract: Provided herein are compounds and methods for modulating the NF?B pathway. More particularly, provided are inhibitors of the NF?B pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: December 12, 2023
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Amarnath Natarajan, Sandeep Rana
  • QUINOXALINE COMPOUNDS AND USES THEREOF
    Publication number: 20230250085
    Abstract: Provided herein are compounds having a structure of formula (I) and methods of using the disclosed compounds to inhibit IKK? activity.
    Type: Application
    Filed: April 17, 2023
    Publication date: August 10, 2023
    Inventor: Amarnath Natarajan
  • SYMBIOTIC PRODRUGS FOR THE TREATMENT OF CANCER AND OTHER DISEASES
    Publication number: 20230174548
    Abstract: Provided herein are compounds and methods for modulating the NFKB pathway. More particularly, provided are inhibitors of the NFkB pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, such as ovarian cancer.
    Type: Application
    Filed: March 19, 2021
    Publication date: June 8, 2023
    Inventor: Amarnath Natarajan
  • Quinoxaline compounds and uses thereof
    Patent number: 11661411
    Abstract: Provided herein are compounds having a structure of formula (I) and methods of using the disclosed compounds to inhibit IKK? activity.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: May 30, 2023
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventor: Amarnath Natarajan
  • Dimers of Covalent NFKB Inhibitors
    Publication number: 20220009941
    Abstract: Provided herein are compounds and methods for modulating the NF?B pathway. More particularly, provided are inhibitors of the NF?B pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.
    Type: Application
    Filed: July 21, 2021
    Publication date: January 13, 2022
    Inventors: Amarnath Natarajan, Sandeep Rana
  • Dimers of covalent NFKB inhibitors
    Patent number: 11104684
    Abstract: Provided herein are compounds and methods for modulating the NF?B pathway. More particularly, provided are inhibitors of the NF?B pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: August 31, 2021
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Amarnath Natarajan, Sandeep Rana
  • Quinoxaline Compounds and Uses Thereof
    Publication number: 20210002258
    Abstract: Provided herein are compounds having a structure of formula (I) and methods of using the disclosed compounds to inhibit IKK? activity.
    Type: Application
    Filed: December 3, 2018
    Publication date: January 7, 2021
    Inventor: Amarnath Natarajan
  • Dimers of Covalent NFKB Inhibitors
    Publication number: 20190322680
    Abstract: Provided herein are compounds and methods for modulating the NFKB pathway. More particularly, provided are inhibitors of the NFKB pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.
    Type: Application
    Filed: December 21, 2017
    Publication date: October 24, 2019
    Inventors: Amarnath Natarajan, Sandeep Rana
  • Substituted quinoxalines as kinase inhibitors
    Patent number: 9353094
    Abstract: Disclosed herein are compounds of formula (I) and methods of inhibiting IKK? and the NF-?B signaling and mTOR pathways.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: May 31, 2016
    Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
    Inventors: Amarnath Natarajan, Qianyi Chen, Vashti C. Bryant, Rajkumar Rajule
  • QUINOXALINE COMPOUNDS AND USES THEREOF
    Publication number: 20150274709
    Abstract: Disclosed herein are compounds of formula (I) and methods of inhibiting IKK? and the NF-?B signaling and mTOR pathways.
    Type: Application
    Filed: March 5, 2015
    Publication date: October 1, 2015
    Inventors: Amarnath Natarajan, Qianyi Chen, Vashti C. Bryant, Rajkumar Rajule
  • Substituted quinoxalines and uses thereof
    Patent number: 8993758
    Abstract: Disclosed herein are compounds of formula (I) and methods of inhibiting IKK? and the NF-?B signaling and mTOR pathways.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: March 31, 2015
    Assignees: Board of Regents of the University of Nebraska, The Board of Regents, University of Texas System
    Inventors: Amarnath Natarajan, Qianyi Chen, Vashti C. Bryant, Rajkumar Rajule
  • QUINOXALINE COMPOUNDS AND USES THEREOF
    Publication number: 20130289041
    Abstract: Disclosed herein are compounds of formula (I) and methods of inhibiting IKK? and the NF-?B signaling and mTOR pathways.
    Type: Application
    Filed: November 22, 2011
    Publication date: October 31, 2013
    Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Amarnath Natarajan, Qianyi Chen, Vashti C. Bryant, Rajkumar Rajule
  • 3-3-di-substituted-oxindoles as inhibitors of translation initiation
    Patent number: 8354440
    Abstract: Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: January 15, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: José A. Halperin, Amarnath Natarajan, Bertal Huseyin Aktas, Yun-Hua Fan, Han Chen
  • 3-3-di-substituted-oxindoles as inhibitors of translation initiation
    Patent number: 8268879
    Abstract: Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: September 18, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: José A. Halperin, Amarnath Natarajan, Huseyin Aktas, Yun-Hua Fan, Han Chen
  • 3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation
    Publication number: 20120077759
    Abstract: Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
    Type: Application
    Filed: September 15, 2011
    Publication date: March 29, 2012
    Applicant: President and Fellows of Harvard College
    Inventors: José A. Halperin, Amarnath Natarajan, Bertal Huseyin Aktas, Yun-Hua Fan, Han Chen
  • 3-3-di-substituted-oxindoles as inhibitors of translation initiation
    Patent number: 8088816
    Abstract: Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl) -3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: January 3, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: José A. Halperin, Amarnath Natarajan, Huseyin Aktas, Yun-Hua Fan, Han Chen
  • 3-3-di-substituted-oxindoles as inhibitors of translation initiation
    Patent number: 8044089
    Abstract: Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: October 25, 2011
    Assignee: President and Fellows of Harvard College
    Inventors: José A. Halperin, Amarnath Natarajan, Huseyin Aktas, Yun-Hua Fan, Han Chen
  • 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION
    Publication number: 20110046367
    Abstract: Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
    Type: Application
    Filed: November 1, 2010
    Publication date: February 24, 2011
    Applicant: President and Fellows of Harvard College
    Inventors: José A. Halperin, Amarnath Natarajan, Huseyin Aktas, Yun-Hua Fan, Han Chen
  • 3-3-di-substituted-oxindoles as inhibitors of translation initiation
    Patent number: 7846962
    Abstract: Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: December 7, 2010
    Assignee: President and Fellows of Harvard College
    Inventors: José A. Halperin, Amarnath Natarajan, Huseyin Aktas, Yun-Hua Fan, Han Chen
  • 3-3-Di-Substituted-Oxindoles As Inhibitors of Translation Initiation
    Publication number: 20100256388
    Abstract: Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
    Type: Application
    Filed: June 9, 2010
    Publication date: October 7, 2010
    Applicant: President and Fellows of Harvard College
    Inventors: José A. Halperin, Amarnath Natarajan, Huseyin Aktas, Yun-Hua Fan, Han Chen