Abstract: Compositions can comprise the catechin metabolite 3?-O-methyl-4?-O-sulfate epicatechin. In some embodiments, the composition can be used in a method for blood vessel dilation and/or increased delivery of blood flow to tissues in the body, for example by administering the composition to an individual having or at risk of high blood pressure or a cardiovascular disease. In some embodiments, the compositions are used for weight maintenance or weight loss. In further embodiments the compositions are used for treating or preventing gestational diabetes mellitus. The compositions may be administered orally as a food product in which the 3?-O-methyl-4?-O-sulfate epicatechinis present in a concentration of at least 0.01 mg/g of the food product.