Patents by Inventor Ameae Walker

Ameae Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPLICE MODULATING OLIGONUCLEOTIDES THAT INHIBIT CANCER
    Publication number: 20180334676
    Abstract: A method of treating cancer in a subject is provided. The method includes administering a splice modulating oligonucleotide to the subject in an amount effective to provide a therapeutic benefit to the subject. In the method, the oligonucleotide modifies splicing of a pre-mRNA encoding a polypeptide promotes cancer cell survival, proliferation, and/or metastasis, or promotes angiogenesis, or a combination thereof; or increases expression of the polypeptide if the polypeptide inhibits angiogenesis, or a combination thereof. Similar methods of treating diseases involving prolactin or the prolactin receptor are also provided.
    Type: Application
    Filed: March 5, 2018
    Publication date: November 22, 2018
    Inventors: Ameae Walker, Mrinal Ghosh, Kuan-Hui Chen, Tomohiro Yonezawa
  • Splice modulating oligonucleotides that inhibit cancer
    Patent number: 9909128
    Abstract: A method of treating cancer in a subject is provided. The method includes administering a splice modulating oligonucleotide to the subject in an amount effective to provide a therapeutic benefit to the subject. In the method, the oligonucleotide modifies splicing of a pre-mRNA encoding a polypeptide, and either: reduces expression of the polypeptide if the polypeptide promotes cancer cell survival, proliferation, and/or metastasis, or promotes angiogenesis, or a combination thereof; or increases expression of the polypeptide if the polypeptide inhibits cancer cell survival, proliferation and/or metastasis, or inhibits angiogenesis, or a combination thereof. Similar methods of treating diseases involving prolactin or the prolactin receptor are also provided.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: March 6, 2018
    Assignee: The Regents of the University of California
    Inventors: Ameae Walker, Mrinal Ghosh, Kuan-Hui Chen, Tomohiro Yonezawa
  • SPLICE MODULATING OLIGONUCLEOTIDES THAT INHIBIT CANCER
    Publication number: 20150337310
    Abstract: A method of treating cancer in a subject is provided. The method includes administering a splice modulating oligonucleotide to the subject in an amount effective to provide a therapeutic benefit to the subject. In the method, the oligonucleotide modifies splicing of a pre-mRNA encoding a polypeptide, and either: reduces expression of the polypeptide if the polypeptide promotes cancer cell survival, proliferation, and/or metastasis, or promotes angiogenesis, or a combination thereof; or increases expression of the polypeptide if the polypeptide inhibits cancer cell survival, proliferation and/or metastasis, or inhibits angiogenesis, or a combination thereof. Similar methods of treating diseases involving prolactin or the prolactin receptor are also provided.
    Type: Application
    Filed: November 15, 2013
    Publication date: November 26, 2015
    Inventors: Ameae Walker, Mrinal Ghosh, Kuan-Hui Chen, Tomohiro Yonezawa
  • Prolactin antagonists and uses thereof
    Patent number: 6890738
    Abstract: Recombinant nucleotide sequences encoding mutated prolactin are described. Expression of the sequences result in mimics of a phosphorylated prolactin corresponding to a selected species. A particularly preferred mimic is mutated at serine 179 (corresponding to human PRL) where serine is substituted by an aspartate residue. This aspartate mutant is a very effective antagonist and shows no ability to stimulate Nb2 to cell proliferation.
    Type: Grant
    Filed: April 23, 1998
    Date of Patent: May 10, 2005
    Assignee: The Regents of the University of California
    Inventor: Ameae Walker