Patents by Inventor Amedeo A. Fantini

Amedeo A. Fantini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extractive purification of lipopeptide antibiotics
    Patent number: 7138487
    Abstract: The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is provided a method of extracting a variety of acidic lipopeptide antibiotics, directly or indirectly, into water immiscible organic solvents by using a divalent cation chelation procedure.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: November 21, 2006
    Assignee: Migenix Inc.
    Inventors: Donald B. Borders, Noreen D. Francis, Amedeo A. Fantini
  • Extractive purification of lipopeptide antibiotics
    Publication number: 20040242467
    Abstract: The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics in high yield and purity.
    Type: Application
    Filed: March 26, 2004
    Publication date: December 2, 2004
    Applicant: MICROLOGIX BIOTECH INC.
    Inventors: Donald B. Borders, Noreen D. Francis, Amedeo A. Fantini
  • Derivatives of laspartomycin and preparation and use thereof
    Patent number: 6737403
    Abstract: The present invention provides laspartomycin core peptides, laspartomycin core peptide derivatives, antimicrobial laspartomycin derivatives, methods for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: May 18, 2004
    Assignee: Micrologix Biotech Inc.
    Inventors: Donald B Borders, William V Curran, Amedeo A Fantini, Noreen D Francis, Howard Jarolmen, Richard A Leese
  • Extractive purification of lipopeptide antibiotics
    Patent number: 6716962
    Abstract: The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is provided a method of extracting a variety of acidic lipopeptide antibiotics, directly or indirectly, into water immiscible organic solvents by using a divalent cation chelation procedure.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: April 6, 2004
    Assignee: Micrologix Biotech Inc.
    Inventors: Donald B Borders, Noreen D Francis, Amedeo A Fantini
  • Derivatives of laspartomycin and preparation and use thereof
    Patent number: 6511962
    Abstract: The present invention provides a laspartomycin core peptide, a laspartomycin core peptide derivative, a antimicrobial laspartomycin derivative, a method for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: January 28, 2003
    Assignee: Micrologix Biotech Inc.
    Inventors: Donald B Borders, William V Curran, Amedeo A Fantini, Noreen D Francis, Howard Jarolmen, Richard A Leese
  • Extractive purification of lipopeptide antibiotics
    Publication number: 20020132762
    Abstract: The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics in high yield and purity.
    Type: Application
    Filed: September 6, 2001
    Publication date: September 19, 2002
    Inventors: Donald B. Borders, Noreen D. Francis, Amedeo A. Fantini
  • Derivatives of laspartomycin and preparation and use thereof
    Publication number: 20020035063
    Abstract: The present invention provides laspartomycin core peptides, laspartomycin core peptide derivatives, antimicrobial laspartomycin derivatives, methods for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspartomycin derivatives, pharmaceutical compositions of antimicrobial laspartomycin derivatives, methods of inhibiting microbial growth and methods for treating and/or preventing microbial infections in a subject.
    Type: Application
    Filed: July 13, 2001
    Publication date: March 21, 2002
    Inventors: Donald B. Borders, William V. Curran, Amedeo A. Fantini, Noreen D. Francis, Howard Jarolmen, Richard A. Reese
  • Antitumor antibiotics (LL-E33288 complex)
    Patent number: 5108912
    Abstract: Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora spp. calichensis NRRL-15839, NRRL-15975 and NRRL-18149, are disclosed.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: April 28, 1992
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Michael Greenstein, David P. Labeda, Amedeo A. Fantini
  • Antitumor antibiotics (LL-E33288 complex)
    Patent number: 4970198
    Abstract: Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora ssp. calichensis NNRL-15839, NRRL-15975 and NRRL-18149, are disclosed.
    Type: Grant
    Filed: January 30, 1987
    Date of Patent: November 13, 1990
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Michael Greenstein, David P. Labeda, Amedeo A. Fantini
  • Biologically pure culture of Streptoverticillium stramineum sp. nov.
    Patent number: 4650765
    Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
    Type: Grant
    Filed: July 30, 1985
    Date of Patent: March 17, 1987
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Amedeo A. Fantini, Donald B. Borders, Raymond T. Testa, John H. E. J. Martin, deceased
  • Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega..sub.1, LL-D49194.omega..sub.2, and LL-D49194.omega..sub.3
    Patent number: 4626503
    Abstract: Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega., LL-D49194.omega..sub.2 and LL-D49194.omega..sub.3.
    Type: Grant
    Filed: February 14, 1985
    Date of Patent: December 2, 1986
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Amedeo A. Fantini, David P. Labeda, William M. Maiese, Raymond T. Testa, Donald B. Borders
  • Preparation of antibiotic LL-D05139.beta. from cultures of Glycomyces harbinensis, gen. nov., sp. nov.
    Patent number: 4568646
    Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139.beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
    Type: Grant
    Filed: January 24, 1985
    Date of Patent: February 4, 1986
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Donald B. Borders, David P. Labeda, Amedeo A. Fantini, Raymond T. Testa
  • Antibiotic LL-BO1208.alpha. and LL-BO1208.beta., process of preparation, pharmaceutical composition and method of use
    Patent number: 4552867
    Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
    Type: Grant
    Filed: July 5, 1983
    Date of Patent: November 12, 1985
    Assignee: American Cyanamid Company
    Inventors: John H. E. J. Martin, Jane P. Kirby, Donald B. Borders, Amedeo A. Fantini, Raymond T. Testa
  • Antibiotic LL-D05139 .beta.
    Patent number: 4503044
    Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139 .beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: March 5, 1985
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Donald B. Borders, David P. Labeda, Amedeo A. Fantini, Raymond T. Testa
  • Antibacterial antibiotic BM782
    Patent number: 4234717
    Abstract: This disclosure describes three new antibiotics designated BM782.alpha.1, BM782.alpha.2, and BM782.alpha.1a which are produced in a microbiological fermentation under controlled conditions using a new strain of an undetermined species of the genus Nocardia or mutants thereof. These new antibacterial agents are active against Mycobacterium tuberculosis as well as both gram-positive and gram-negative microorganisms and thus are useful for inhibiting the growth of such bacteria and bacilli wherever they may be found.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: November 18, 1980
    Assignee: American Cyanamid Company
    Inventors: Homer D. Tresner, Amedeo A. Fantini, Donald B. Borders, William J. McGahren