Patents by Inventor Amelia A. Schabel

Amelia A. Schabel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A-82846-type glycopeptide antibiotics
    Patent number: 6111067
    Abstract: A82846-related glycopeptide compounds are prepared by treating an antibiotic selected from A82846 components A, B and C with trifluoroacetic acid to remove 1) the .alpha.-L-O-4-epi-vancosaminyl group attached to the disaccharide; 2) the (.alpha.-L-O-4-epi-vancosaminyl-.beta.-O-glucosyl) disaccharide group or 3) both the disaccharide group and the .alpha.-L-O-4-epi-vancosaminyl group attached to the peptide core from these antibiotics. The compounds have antibacterial activity, especially against Gram-positive microorganisms.
    Type: Grant
    Filed: December 21, 1993
    Date of Patent: August 29, 2000
    Assignee: Eli Lilly and Company
    Inventors: Manuel Debono, R. Michael Molloy, Ramakrishnan Nagarajan, Amelia A. Schabel
  • Derivatives of A82846
    Patent number: 5591714
    Abstract: New N-alkyl and N-acyl derivatives of A82846A, A82846B, A82846C and PA-42867-A are provided. The new glycopeptide derivatives are useful for the treatment of susceptible bacterial infections, especially infections due to Gram-positive microorganisms.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: January 7, 1997
    Assignee: Eli Lilly and Company
    Inventors: Ramakrishnan Nagarajan, Amelia A. Schabel
  • Novel glycopeptide derivatives
    Patent number: 4698327
    Abstract: Novel glycopeptide antibiotics of formula (I) can be prepared from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D by reaction with a ketone or aldehyde followed, if appropriate, by reduction. The new glycopeptide derivatives are useful antibacterial agents.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: October 6, 1987
    Assignee: Eli Lilly and Company
    Inventors: Ramakrishnan Nagarajan, Amelia A. Schabel
  • Modified glycopeptides
    Patent number: 4643987
    Abstract: Novel aracyl glycopeptide derivatives of formula 1 and methods for their preparation from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D, are provided. The new glycopeptide derivatives are useful antibacterial agents.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: February 17, 1987
    Assignee: Eli Lilly and Company
    Inventors: Ramakrishnan Nagarajan, Amelia A. Schabel
  • Glycopeptide derivatives
    Patent number: 4639433
    Abstract: Novel glycopeptide derivatives of formula 1 and methods for their preparation from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D, are provided. The new glycopeptide derivatives are useful antibacterial agents.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: January 27, 1987
    Assignee: Eli Lilly and Company
    Inventors: Ann H. Hunt, R. Michael Molloy, Ramakrishnan Nagarajan, Amelia A. Schabel
  • Glycopeptide antibiotics and process of preparation
    Patent number: 4552701
    Abstract: Desvancosaminyl- and des(vancosaminyl-O-glucosyl) glycopeptides, and methods for their preparation by treating a glycopeptide selected from vancomycin, A51568A, A51568B, M43A and M43D with trifluoroacetic acid under controlled conditions, are provided. The new glycopeptides are useful antibacterial agents.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: November 12, 1985
    Assignee: Eli Lilly and Company
    Inventors: Ramakrishnan Nagarajan, Amelia A. Schabel