Patents by Inventor Amelie Montel Hagen

Amelie Montel Hagen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BCL11B Overexpression to Enhance Human Thymopoiesis and T Cell Function
    Publication number: 20220347222
    Abstract: Methods of treating a subject using a T cell therapy are disclosed herein. The methods include increasing BCL11B expression in hematopoietic stem and progenitor cells (HSPCs), pluripotent stem cells, or mature T cells to form modified cells and administering a therapeutically effective amount of the modified cells to the subject for the T cell therapy. BCL11B expression in the HSPCs, pluripotent stem cells, or mature T cells increases production and/or proliferation of T cells from the HSPCs and/or the pluripotent stem cells, and/or increases proliferation of the T cells.
    Type: Application
    Filed: June 24, 2020
    Publication date: November 3, 2022
    Applicants: The Regents of the University of California, Children's Hospital Los Angeles
    Inventors: Chintan PAREKH, Gay CROOKS, Christopher SEETS, Amelie Montel-Hagen
  • METHODS OR GENERATING T-CELLS FROM STEM CELLS AND IMMUNOTHERAPEUTIC METHODS USING THE T-CELLS
    Publication number: 20220096553
    Abstract: Methods and composition for production of T cells are provided. Also provided are therapeutic methods using engineered T cells. For example, in certain aspects methods include preparing three dimensional cell culture compositions comprising stroma cells and hematopoietic stem or progenitor cells in a serum-free medium for producing T cells.
    Type: Application
    Filed: September 17, 2021
    Publication date: March 31, 2022
    Applicant: The Regents of the University of California
    Inventors: Gay M. CROOKS, Amélie MONTEL-HAGEN, Christopher SEET
  • Methods of generating T-cells from stem cells and immunotherapeutic methods using the T-cells
    Patent number: 11154573
    Abstract: Methods and composition for production of T cells are provided. Also provided are therapeutic methods using engineered T cells. For example, in certain aspects methods include preparing three dimensional cell culture compositions comprising stroma cells and hematopoietic stem or progenitor cells in a serum-free medium for producing T cells.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: October 26, 2021
    Assignee: The Regents of the University of California
    Inventors: Gay M. Crooks, Amélie Montel-Hagen, Christopher Seet
  • STEM CELL-ENGINEERED INKT CELL-BASED OFF-THE-SHELF CELLULAR THERAPY
    Publication number: 20210123022
    Abstract: Embodiments of the disclosure include compositions and methods related to engineered invariant natural killer T (iNKT) cells for off-the-shelf use for clinical therapy. In particular embodiments, the iNKT cells are produced from hematopoietic stem progenitor cells and also are suitable for allogeneic cellular therapy because they are HLA negative. In specific embodiments, the cells are cultured in a particular in vitro three-dimensional artificial thymic organoid system and the cells have imaging and suicide targeting capabilities.
    Type: Application
    Filed: June 12, 2019
    Publication date: April 29, 2021
    Applicant: The Regents of the University of California
    Inventors: Lili Yang, Yanni Zhu, Christopher Seet, Amelie Montel Hagen, Gay Crooks
  • METHODS OF GENERATING T-CELLS FROM STEM CELLS AND IMMUNOTHERAPEUTIC METHODS USING THE T-CELLS
    Publication number: 20190231817
    Abstract: Methods and composition for production of T cells are provided. Also provided are therapeutic methods using engineered T cells. For example, in certain aspects methods include preparing three dimensional cell culture compositions comprising stroma cells and hematopoietic stem or progenitor cells in a serum-free medium for producing T cells.
    Type: Application
    Filed: October 28, 2016
    Publication date: August 1, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Gay M. CROOKS, Amélie MONTEL-HAGEN, Christopher SEET