Patents by Inventor Ameng ZHOU

Ameng ZHOU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
    Patent number: 11512303
    Abstract: The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of ?-hydroxy-?-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing ?-hydroxy-?-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of ?-hydroxy-?-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: November 29, 2022
    Assignee: ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD.
    Inventors: Haibin Chen, Yong Koy Bong, Qing Xu, Ameng Zhou, Tianran Shen, Jiadong Yang, Zhuhong Yang
  • Engineered aldolase polypeptides and uses thereof
    Patent number: 11274287
    Abstract: The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of ?-hydroxy-?-amino acids under industrial-relevant conditions. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing ?-hydroxy-?-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of ?-hydroxy-?-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: March 15, 2022
    Assignee: Enzymaster (Ningbo) Bio-Engineering Co., Ltd
    Inventors: Haibin Chen, Yong Koy Bong, Baoqin Cai, Qing Xu, Tianran Shen, Ameng Zhou, Jiadong Yang, Zhuhong Yang, Yaoyao Ji, Yingxin Zhang
  • ENGINEERED POLYPEPTIDES AND THEIR APPLICATIONS IN THE SYNTHESIS OF BETA-HYDROXY-ALPHA-AMINO ACIDS
    Publication number: 20210284987
    Abstract: The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of ?-hydroxy-?-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing ?-hydroxy-?-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of ?-hydroxy-?-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.
    Type: Application
    Filed: May 9, 2018
    Publication date: September 16, 2021
    Inventors: Haibin CHEN, Yong Koy BONG, XU Qing, Ameng ZHOU, Tianran SHEN, Jiadong YANG, Zhuhong YANG