Patents by Inventor Amer El-Hage
Amer El-Hage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11035495Abstract: A flow control mechanism and a system comprising the mechanism, specifically relating to a microflow control mechanism and system. The mechanism comprises a base and a constant volume mechanism. The base and the constant volume mechanism are dynamically connected to form two or more relative activity states, comprising a first relative state and a second relative state. A fluid input end and a fluid receiving end are provided on the base. The constant volume mechanism is provided with a constant volume pipeline. In the first relative state, the fluid input end communicates with the constant volume pipeline. In the second relative state, the constant volume pipeline communicates with the fluid receiving end. The microflow control mechanism and system can achieve precise micro-scale fluid flow control, and have a simple structure.Type: GrantFiled: July 6, 2016Date of Patent: June 15, 2021Assignee: HELIXGEN (GUANGZHOU) CO., LTD.Inventors: Tianxian Zhao, Qing Zeng, Zhongman Zhang, Amer El-Hage
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Publication number: 20190301640Abstract: A flow control mechanism and a system comprising the mechanism, specifically relating to a microflow control mechanism and system. The mechanism comprises a base and a constant volume mechanism. The base and the constant volume mechanism are dynamically connected to form two or more relative activity states, comprising a first relative state and a second relative state. A fluid input end and a fluid receiving end are provided on the base. The constant volume mechanism is provided with a constant volume pipeline. In the first relative state, the fluid input end communicates with the constant volume pipeline. In the second relative state, the constant volume pipeline communicates with the fluid receiving end. The microflow control mechanism and system can achieve precise micro-scale fluid flow control, and have a simple structure.Type: ApplicationFiled: July 6, 2016Publication date: October 3, 2019Inventors: Tianxian ZHAO, Qing ZENG, Zhongman ZHANG, Amer EL-HAGE
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Patent number: 6902703Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.Type: GrantFiled: February 5, 2001Date of Patent: June 7, 2005Assignee: LJL Biosystems, Inc.Inventors: Samuel A. Marquiss, Christopher G. Cesar, Jon F. Petersen, David P. Stumbo, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin, Lev J. Leytes, Samuel Burd
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Patent number: 6838051Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.Type: GrantFiled: February 6, 2001Date of Patent: January 4, 2005Assignee: LJL BioSystems, Inc.Inventors: Samuel A. Marquiss, Christopher G. Cesar, Jon F. Petersen, David P. Stumbo, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin, Ley J. Leytes, Samuel Burd
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Publication number: 20030127609Abstract: Systems, and components thereof, for analyzing samples. These systems include apparatus and methods for generating, transmitting, detecting, and/or analyzing light, including without limitation high-throughput optical screening devices for analyzing samples at one or more assay sites. These systems also include apparatus and methods for supporting samples for analysis, including without limitation multiwell sample holders such as microplates.Type: ApplicationFiled: August 13, 2002Publication date: July 10, 2003Inventors: Amer El-Hage, Christopher G. Cesar, Douglas N. Modlin, Glenn R. Edwards, John C. Owicki, Joh W. Meadows, Michael T. Taylor, Samuel A. Marquiss, Jonathan F. Petersen, David P. Stumbo
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Patent number: 6576476Abstract: A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.Type: GrantFiled: April 29, 1999Date of Patent: June 10, 2003Assignee: LJL BioSystems, Inc.Inventors: Michael T. Taylor, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin
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Patent number: 6499366Abstract: Devices for automatically feeding sample containers into and out of an analyzer. The device may include (1) a first station that receives and initiates transport of a sample container into an analyzer for analysis, (2) a second station where the sample container is handed off to a transporter that carries the sample container to and from an examination site inside the analyzer, and (3) a third station that collects the sample container after examination. The device also may include a singulation mechanism configured to separate a sample container from a stack of sample containers, and/or a stacking mechanism configured to add a sample container to a stack of sample containers. The singulation and stacking mechanisms may include lifter and latch components.Type: GrantFiled: August 31, 1998Date of Patent: December 31, 2002Assignee: LJL BioSystems, Inc.Inventors: John W. Meadows, Glenn R. Edwards, Samuel A. Marquiss, Amer El-Hage, Douglas N. Modlin
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Patent number: 6488892Abstract: Sample-holding devices and systems for efficiently utilizing relatively small-volume fluid samples.Type: GrantFiled: January 5, 2000Date of Patent: December 3, 2002Assignee: LJL BioSystems, Inc.Inventors: William G. Burton, Douglas N Modlin, Derrick A. Richardson, Jon F. Petersen, Joseph S. Leytes, John C. Owicki, Amer El-Hage, Lev J. Leytes
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Patent number: 6486947Abstract: Devices and methods for containing and analyzing small sample volumes that are sandwiched between solid surfaces. The devices may include an automated drive mechanism that controls the relative positions of the surfaces and an environmental-control mechanism that controls the humidity, temperature, and/or other environmental conditions around the small sample volume. In some embodiments, at least one of the surfaces has a light-transmissive window for allowing optical analysis of a sample contained between the surfaces.Type: GrantFiled: January 22, 2001Date of Patent: November 26, 2002Assignee: LJL BioSystems, Inc.Inventors: Douglas N. Modlin, Amer El-Hage, John C. Owicki
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Publication number: 20020009391Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.Type: ApplicationFiled: February 6, 2001Publication date: January 24, 2002Applicant: LJL BioSystems, Inc.Inventors: Samuel A. Marquiss, Christopher S. Cesar, Jon F. Petersen, David P. Stumbo, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin, Ley J. Leytes, Samuel Burd
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Publication number: 20010048899Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.Type: ApplicationFiled: February 5, 2001Publication date: December 6, 2001Applicant: LJL BioSystems, Inc.Inventors: Samuel A. Marouiss, Christopher G. Cesar, Jon F. Petersen, David P. Stumbo, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin, Lev J. Leytes, Samuel Burd
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Patent number: 6313960Abstract: Devices for using optical filters in a filter holder that enable optical filters to be simply, conveniently, and flexibly interchanged.Type: GrantFiled: July 16, 1998Date of Patent: November 6, 2001Assignee: LJL Biosystems, Inc.Inventors: Samuel A. Marquiss, Calvin D. Wong, Glenn R. Edwards, Michael T. Taylor, Philip A. Granieri, Jr., Douglas N. Modlin, Amer El-Hage
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Publication number: 20010021074Abstract: Devices for using optical filters in a filter holder that enable optical filters to be simply, conveniently, and flexibly interchanged.Type: ApplicationFiled: July 16, 1998Publication date: September 13, 2001Inventors: SAMUEL A. MARQUISS, CALVIN D. WONG, GLENN R. EDWARDS, MICHAEL T. TAYLOR, PHIL A. GARNIERI, DOUGLAS N. MODLIN, AMER EL-HAGE
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Publication number: 20010006417Abstract: Devices and methods for containing and analyzing small sample volumes that are sandwiched between solid surfaces. The devices may include an automated drive mechanism that controls the relative positions of the surfaces and an environmental-control mechanism that controls the humidity, temperature, and/or other environmental conditions around the small sample volume. In some embodiments, at least one of the surfaces has a light-transmissive window for allowing optical analysis of a sample contained between the surfaces.Type: ApplicationFiled: January 22, 2001Publication date: July 5, 2001Applicant: LJL BioSystems, Inc.Inventors: Douglas N. Modlin, Amer El-Hage, John C. Owicki
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Patent number: 6187267Abstract: A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.Type: GrantFiled: September 2, 1998Date of Patent: February 13, 2001Assignee: LJL BioSystems, Inc.Inventors: Michael T. Taylor, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin
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Patent number: 6097025Abstract: A high-throughput light detection instrument and method are described. In some embodiments, switch mechanisms and optical relay structures permit different light sources and/or detectors to be selected for different applications. In other embodiments, switch mechanisms and optical paths permit top/bottom illumination and/or top/bottom detection, or combinations thereof.Type: GrantFiled: September 24, 1998Date of Patent: August 1, 2000Assignee: LJL BioSystems, Inc.Inventors: Douglas N. Modlin, Glenn R. Edwards, Michael T. Taylor, Samuel A. Marquiss, Amer El-Hage, Craig S. Barker, Lorne B. Bechtel, Rick V. Stellmacher, Philip A. Granieri, Jr., Robert M. Lembi, Sr.
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Patent number: 6025985Abstract: A moveable control unit for a high-throughput analyzer that can be operatively mounted at a plurality of locations on the analyzer housing.Type: GrantFiled: July 16, 1998Date of Patent: February 15, 2000Assignee: LJL BioSystems, Inc.Inventors: Lev J. Leytes, William G. Burton, Yong Paik, Glenn R. Edwards, Douglas N. Modlin, Amer El-Hage
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Patent number: 5964381Abstract: A piston is disposed inside a tube having an inner cross sectional size and shape uniform along its length. The tube has an open end. The piston is free to move linearly inside the tube and preferably may move out of the tube through the open end. If the tube is cylindrical, for example, it has a constant inner diameter. The open end of the tube is neither tapered or flaring. Liquid samples are aspirated into the device by pulling the piston back. The sample is then ejected by accelerating the piston to a minimum velocity to force the liquid sample out of the open end of the tube. The velocity of the sample is sufficient to render negligible the effects of surface tension forces. The volume of the liquid sample dispensed is determined by the inner diameter of the tube and the piston displacement. Accurate positioning of the piston provides samples of accurate volumes. A specific embodiment of the present invention uses a tube with an inner diameter of 0.5 mm, resulting in a volume displacement of 1.Type: GrantFiled: November 12, 1997Date of Patent: October 12, 1999Assignee: LJL BioSystems, Inc.Inventors: Amer El-Hage, Joseph Leytes
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Patent number: 5843378Abstract: A method of producing a probe for aspirating and dispensing liquid. A fluid conduit and rod are positioned in the central bore of a tube so that an inlet end of the conduit and a contact end of the rod protrude from an upper end of the tube and a discharge end of the conduit and a sensing end of the rod protrude from a lower end of the tube. The tube has a heat-shrinkable outer layer and a meltable inner layer. The tube is heated so that its outer layer shrinks and its inner layer melts to encapsulate middle portions of the conduit and rod. A circuit board having first and second traces and first and second holes is placed on the upper end of the tube so that the inlet end of the conduit is inserted through the first hole and the contact end of the rod is inserted through the second hole. The conduit and rod are attached to the board so that the conduit is electrically connected to the first trace and the rod is electrically connected to the second trace.Type: GrantFiled: January 29, 1997Date of Patent: December 1, 1998Assignee: LJL BiosystemsInventors: Amer El-Hage, Rick V. Stellmacher
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Patent number: 5604130Abstract: A cover effective to releasably seal a multiwell container, such as a microtitration plate, is disclosed. The cover contains a pad, fashioned from a flexible polymer sheet, and a plurality of resiliently compressible ridges formed on the sheet. The ridges are deformable, such that application of pressure applied to the cover is effective to form a fluid-tight seal between the pad and the well openings. The ridges extend from the pad sufficiently to break the seal upon release of the pressure.Type: GrantFiled: May 31, 1995Date of Patent: February 18, 1997Assignees: Chiron Corporation, LJL Biosystems, Inc.Inventors: Brian D. Warner, Benjamin T. Nordell, Bruce J. Richardson, Amer El-Hage