Patents by Inventor Amha Atakilit

Amha Atakilit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treating and preventing disease associated with alpha-v beta-8 integrin
    Patent number: 11492406
    Abstract: Methods and compositions comprising integrin ?8 antibodies are provided.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: November 8, 2022
    Assignee: The Regents of the University of California
    Inventors: Dean Sheppard, Amha Atakilit, Neil Cowan Henderson
  • ANTI-AVBETA8 ANTIBODIES AND COMPOSITIONS AND USES THEREOF
    Publication number: 20220289850
    Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ?v?8 integrin. The invention includes uses, and associated methods of using the antibodies.
    Type: Application
    Filed: May 13, 2022
    Publication date: September 15, 2022
    Applicants: PFIZER INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kyle Steven Niessen, Dharmaraj Samuel, Charles Ray Holst, Matthew Ross Drever, Dean Sheppard, Rosemary J. Akurst, Amha Atakilit, Dominique Meyer, Isaac J. Rondon, Joseph Dal Porto
  • Anti-AVB8 antibodies and compositions and uses thereof
    Patent number: 11359024
    Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ?v?8 integrin. The invention includes uses, and associated methods of using the antibodies.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: June 14, 2022
    Assignees: PFIZER INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kyle Steven Niessen, Dharmaraj Samuel, Charles Ray Holst, Matthew Ross Drever, Dean Sheppard, Rosemary J. Akhurst, Amha Atakilit, Dominique Meyer, Isaac J. Rondon, Joseph Dal Porto
  • METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH ALPHA-V BETA-8 INTEGRIN
    Publication number: 20200247891
    Abstract: Methods and compositions comprising integrin ?8 antibodies are provided.
    Type: Application
    Filed: February 14, 2020
    Publication date: August 6, 2020
    Inventors: Dean Sheppard, Amha Atakilit, Neil Cowan Henderson
  • Methods and compositions for treating and preventing disease associated with alpha-v beta-8 integrin
    Patent number: 10597455
    Abstract: Methods and compositions comprising integrin ?8 antibodies are provided.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: March 24, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dean Sheppard, Amha Atakilit, Neil Cowan Henderson
  • ANTI-AVB8 ANTIBODIES AND COMPOSITIONS AND USES THEREOF
    Publication number: 20200079855
    Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ?v?8 integrin. The invention includes uses, and associated methods of using the antibodies.
    Type: Application
    Filed: September 5, 2019
    Publication date: March 12, 2020
    Inventors: Kyle Steven Niessen, Dharmaraj Samuel, Charles Ray Holst, Matthew Ross Drever, Dean Sheppard, Rosemary J. Akhurst, Amha Atakilit, Dominique Meyer, Isaac J. Rondon, Joseph Dal Porto
  • MILK FAT GLOBULE EPIDERMAL GROWTH FACTOR 8 REGULATES FATTY ACID UPTAKE
    Publication number: 20180340027
    Abstract: Methods and compositions for regulating fatty acid uptake and/or decreasing gastric motility in an animal are provided.
    Type: Application
    Filed: June 4, 2018
    Publication date: November 29, 2018
    Inventors: Kamran Atabai, Sayyed M. Amin Khalifeh-Soltani, Dean Sheppard, Amha Atakilit
  • Methods and compositions for treating and preventing disease associated with ?v?5 integrin
    Patent number: 10087252
    Abstract: The present invention provides compositions and methods for treating and preventing disease associated with ?v?5 integrin by blocking binding to ?v?5 integrin. In particular, antibodies specific for ?v?5 integrin are useful for preventing, treating, and reversing sepsis.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: October 2, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dean Sheppard, George Su, Amha Atakilit
  • METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH ALPHA-V BETA-8 INTEGRIN
    Publication number: 20180230217
    Abstract: Methods and compositions comprising integrin ?8 antibodies are provided.
    Type: Application
    Filed: April 10, 2018
    Publication date: August 16, 2018
    Inventors: Dean Sheppard, Amha Atakilit, Neil Cowan Henderson
  • Milk fat globule epidermal growth factor 8 regulates fatty acid uptake
    Patent number: 10005838
    Abstract: Methods and compositions for regulating fatty acid uptake and/or decreasing gastric motility in an animal are provided. The method comprises administering an antagonist of integrin ?v?3 or ?v?5 to an animal in an amount sufficient to reduce fatty acid uptake in the animal, thereby reducing fatty acid uptake in the animal. In some embodiments, the antagonist is an antibody. Also provided is a method of increasing fatty acid uptake and/or gastric motility in an animal.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: June 26, 2018
    Assignee: The Regents of the University of California
    Inventors: Kamran Atabai, Sayyed M. Amin Khalifeh-Soltani, Dean Sheppard, Amha Atakilit
  • Methods and compositions for treating and preventing disease associated with alpha-V beta-8 integrin
    Patent number: 9969804
    Abstract: Antibodies (e.g., isolated antibodies) that specifically bind to human integrin ?8 and inhibit adhesion of latency associated peptide (LAP) to ?v?8 are provided. In some embodiments, the antibody cross-reacts with mouse integrin ?8. In some embodiments, the antibody blocks TGFJ3 activation. In some embodiments, the antibody antagonizes binding of LAP to ??8 with an IC50 below 5 nM.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: May 15, 2018
    Assignee: The Regents of the University of California
    Inventors: Dean Sheppard, Amha Atakilit, Neil Cowan Henderson
  • MILK FAT GLOBULE EPIDERMAL GROWTH FACTOR 8 REGULATES FATTY ACID UPTAKE
    Publication number: 20160152710
    Abstract: Methods and compositions for regulating fatty acid uptake and/or decreasing gastric motility in an animal are provided. The method comprises administering an antagonist of integrin ?v?3 or ?v?5 to an animal in an amount sufficient to reduce fatty acid uptake in the animal, thereby reducing fatty acid uptake in the animal. In some embodiments, the antagonist is an antibody. Also provided is a method of increasing fatty acid uptake and/or gastric motility in an animal.
    Type: Application
    Filed: July 17, 2014
    Publication date: June 2, 2016
    Inventors: Kamran Atabai, Sayyed M. Amin Khalifeh-Soltani, Dean Sheppard, Amha Atakilit
  • METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH ALPHA-V BETA-8 INTEGRIN
    Publication number: 20160046717
    Abstract: Antibodies (e.g., isolated antibodies) that specifically bind to human integrin ?8 and inhibit adhesion of latency associated peptide (LAP) to ?v?8 are provided. In some embodiments, the antibody cross-reacts with mouse integrin ?8. In some embodiments, the antibody blocks TGFJ3 activation. In some embodiments, the antibody antagonizes binding of LAP to ??8 with an IC50 below 5 nM.
    Type: Application
    Filed: April 1, 2014
    Publication date: February 18, 2016
    Inventors: Dean Sheppard, Amha Atakilit, Neil Cowan Henderson
  • METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH AVB5 INTEGRIN
    Publication number: 20120328604
    Abstract: The present invention provides compositions and methods for treating and preventing disease associated with ?v?5 integrin by blocking binding to ?v?5 integrin. In particular, antibodies specific for ?v?5 integrin are useful for preventing, treating, and reversing sepsis.
    Type: Application
    Filed: July 26, 2010
    Publication date: December 27, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dean Sheppard, George Su, Amha Atakilit
  • Methods and compositions for treating and preventing disease associated with ?V?5 integrin
    Patent number: 7815908
    Abstract: The present invention provides compositions and methods for treating and preventing disease associated with ?v?5 integrin by blocking binding to ?v?5 integrin.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: October 19, 2010
    Assignee: Regents of the University of California
    Inventors: Dean Sheppard, Amha Atakilit
  • METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING DISEASE ASSOCIATED WITH alphaVbeta5 INTEGRIN
    Publication number: 20090280118
    Abstract: The present invention provides compositions and methods for treating and preventing disease associated with ?v?5 integrin by blocking binding to ?v?5 integrin.
    Type: Application
    Filed: July 17, 2009
    Publication date: November 12, 2009
    Applicant: The Regents of the University of California
    Inventors: Dean Sheppard, Amha Atakilit
  • Methods and compositions for treating and preventing diseases associated with alphavbeta5 integrin
    Publication number: 20050226865
    Abstract: The present invention provides compositions and methods for treating and preventing disease associated with ?v?5 integrin by blocking binding to ?v?5 integrin.
    Type: Application
    Filed: March 30, 2005
    Publication date: October 13, 2005
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dean Sheppard, Amha Atakilit