Abstract: Disclosed herein are compositions for generating a synthetic antibody or synthetic multivalent antibody in a subject. Also disclosed are methods for generating a synthetic antibody or synthetic multivalent antibody in a subject by administering a composition including one or more recombinant nucleic acid sequence that encodes a synthetic antibody or synthetic multivalent antibody to the subject. The disclosure also provides a compositions and methods of preventing and/or treating a Neisseria gonorrhoeae infection in a subject using said synthetic antibody or synthetic multivalent antibody.

Abstract: Disclosed herein are compositions for generating a synthetic antibody or synthetic multivalent antibody in a subject. Also disclosed are methods for generating a synthetic antibody or synthetic multivalent antibody in a subject by administering a composition including a recombinant nucleic acid sequence that encodes an antibody, a synthetic antibody, or a synthetic multivalent antibody to a subject. The disclosure also provides compositions and methods of preventing and/or treating a bacterial infection in a subject using said antibody, synthetic antibody, or synthetic multivalent antibody.

Abstract: Computer generated speech can be generated for cross-lingual natural language textual data streams by utilizing a universal phoneme set. In a variety of implementations, the natural language textual data stream includes a primary language portion in a primary language and a secondary language portion that is not in the primary language. Phonemes corresponding to the secondary language portion can be determined from a set of phonemes in a universal data set. These phonemes can be mapped back to a set of phonemes for the primary language. Audio data can be generated for these phonemes to pronounce the secondary language portion of the natural language textual data stream utilizing phonemes associated with the primary language.

Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.

Abstract: Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.

Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.

Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets PCSK9. The disclosure also provides a method of preventing and/or treating disease, such as cardiovascular disease or hypercholesterolemia, in a subject using the composition of the invention.

Abstract: Computer generated speech can be generated for cross-lingual natural language textual data streams by utilizing a universal phoneme set. In a variety of implementations, the natural language textual data stream includes a primary language portion in a primary language and a secondary language portion that is not in the primary language. Phonemes corresponding to the secondary language portion can be determined from a set of phonemes in a universal data set. These phonemes can be mapped back to a set of phonemes for the primary language. Audio data can be generated for these phonemes to pronounce the secondary language portion of the natural language textual data stream utilizing phonemes associated with the primary language.

Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an Ebola viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Ebola virus infection in a subject using said composition and method of generation.

Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.

Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an Ebola viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Ebola virus infection in a subject using said composition and method of generation.

Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to: transmit a wakeup signal to a plurality of devices based on coarse grain location information; send a request to a first device of the plurality of devices to transmit a token using a first communication technology to determine fine grain copresence; receive a first token acknowledgment from a first subset of the plurality of devices; send a request to a second device of the first subset of the plurality of devices to transmit the token using a second communication technology to determine fine grain copresence; receive a second token acknowledgment from a second subset of the plurality of devices; and refine copresence based on receiving the first and second token acknowledgment.

Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.

Abstract: Disclosed herein are mono and bispecific DNA antibodies (DMAbs) targeting Pseudomonas aeruginosa. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the DMAbs to the subject. The disclosure also provides a method of preventing and/or treating Pseudomonas aeruginosa infection in a subject using said composition and method of generation.

Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemagglutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said composition and method of generation.

Abstract: Disclosed herein is a composition comprising the combination of a nucleic acid sequence encoding a desired polypeptide that elicits an immune response in a mammal and a nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof.

Abstract: Provided are assays or methods for identifying antibodies that bind to microorganisms, e.g., pathogenic microorganisms, such as bacteria other infectious agents. In some embodiments, the provided methods for identifying an antibody that binds the target microorganism involves gel encapsulation of antibody-producing cells in gel microdroplets with a target microorganism. Also provided are antibodies produced by the method. Also provided are antibodies that bind a conserved region or epitope across variants or species of Acenitobacter.

Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to receive user input regarding copresence detection settings for a first user device, the copresence detection settings comprising a location and/or a user access control list, and determine a current location of the first user device. The system may determine whether copresence detection of the first user device is enabled at the current location based on the copresence detection settings and the current location. Based on determining that copresence detection is enabled, the system may refine copresence and perform an action based on fine grain copresence of the first and second user device.

Abstract: A method and system are disclosed for determining a task for a subject, which includes sensing electrical activity along a scalp of a subject; characterizing a mental state of the subject based on the electrical activity of the subject; comparing the mental state of the subject with a pre-defined task list to select a task for the subject based on the mental state of the subject; and assigning the task to the subject based on the comparison of the mental state of the subject and the pre-defined task list.

Abstract: The disclosure includes a system and method for detecting fine grain copresence between users. The system includes a processor and a memory storing instructions that when executed cause the system to: process one or more signals to determine coarse grain location information of a first device and a second device; determine whether the first device and the second device are copresent based on the coarse grain location information; in response to determining that the first device and the second device are copresent based on the coarse grain location information, transmit a signal to the second device to alert the second device to listen for a fine grain copresence token from the first device; and refine copresence based on receiving an indication that the second device has received the fine grain copresence token.