Abstract: A system for introducing a therapeutic agent into a diffusion device and for enabling evacuation of contents contained therein the diffusion device characterized as having at least one interior reservoir accessible through a penetrable external device layer comprising one or more ports installed or installable to the external device layer, and an agent delivery mechanism coupled to at least one of the ports.

Abstract: An oxygen-producing device has a power supply with an electrically positive and an electrically negative output, at least one pair of electrodes, one electrode of the pair coupled to the electrically positive output and the other coupled to the electrically negative output, an oxygen-rich material exposed to the electrodes for producing oxygen in response to a voltage generated across the electrodes, and an envelope containing the power supply, the pair of electrodes and the oxygen rich material. The device operates within a human tumor, the envelope— comprises a gas-permeable membrane for releasing the produced oxygen into an environment outside of the envelope and the power supply is enabled to provide a DC voltage of at least 1.2 volts to the electrodes.

Abstract: A wound dressing has a reservoir between a not-permeable upper layer, and a lower permeable layer, an adhesion layer facing in the direction of the permeable layer, to be pressed to skin of a patient around a wound, sealing the dressing to the patient, and one or the other of an oxygen-level indicator containing a material exhibiting color change with varying concentration of oxygen, the indicator placed to be visible to a person viewing the dressing through an interface not permeable to oxygen, and to be open to oxygen through a second interface in intimate contact with oxygen in the reservoir, or a self-sealing opening through which a hollow tube may pass without allowing oxygen to escape, the self-sealing opening useful for charging the reservoir with oxygen at pressure, or for sampling oxygen in the reservoir by an external probe.

Abstract: A diffusing device for treating tissue has multiple cells arranged in a cell layer, the cells filled with or charged with a therapeutic agent, an occlusive layer in direct communication with the cell layer, and a diffusion layer in direct communication with the cell layer. In use the diffusing device is sealed peripherally about an area of tissue and therapeutic agent is released from the cells through the diffusion layer based on the diffusion properties of the diffusion layer.

Abstract: A method for manufacturing a diffusion dressing includes automated steps for pre-forming and precutting a first occlusive layer and precutting a permeable layer of material to a finished size, coating one side of the permeable layer with a permeable adhesive, placing precut sections of a cellular material layer onto the adhesive side of the permeable layer, sealing the first occlusive layer to the permeable layer, precutting a section of absorbent material to a finished size, coating the remaining side of the permeable layer with a permeable adhesive, placing the section of absorbent material on the coated side of the permeable layer, applying a seal about the periphery of the remaining side of the absorbent material, pre-forming and precutting an adhesion layer to a finished size, precutting a removable second occlusive layer of material to a finished size, and sealing the second occlusive layer against the adhesion layer.

Abstract: A therapeutic dressing has a permeable bottom layer, a non-permeable upper layer sealed about the periphery to the permeable layer to form at least one reservoir, an absorbent patch integrated with the permeable layer, a hermetic seal attached to the underside of the permeable layer and a filling interface in communication with the reservoir. The dressing is filled with a therapeutic agent and wherein such agent is subsequently diffused through the permeable layer onto the skin of a patient.

Abstract: A diffusion dressing is provided comprising a paper liner, a hydrocolloid layer, a first adhesive layer, a first barrier layer with a center cutout, an oxygen release layer, an absorbent layer, a second barrier layer, and a second adhesive layer with a center cutout. In a preferred embodiment the diffusion dressing is used for diffusing oxygen into a wound.

Abstract: An oxygen-producing device for aiding in treatment of diseases and conditions of the human eye has a power supply with an electrical output, and at least one pair of electrodes, one electrode of the pair coupled to the electrically positive output and the other coupled to the electrically negative output. The device is characterized in that the device is sized to occupy no more than one fortieth of the volume of an average human eye, and the power supply is enabled to provide a DC voltage of at least 1.2 volts over a period of time.

Abstract: A method supported by machine automation is provided for fulfilling a request for a diffusion dressing comprising the steps (a) translating the request into a set of machine readable instructions the translation performed by the machine receiving the request, (b) equating the commands in the machine instruction set to a build sequence known to the machine that received the request, (c) executing the build sequence to create the diffusion dressing, and (d) dispensing the diffusion dressing from the machine.

Abstract: A system for introducing a therapeutic agent into a diffusion device and for enabling evacuation of contents contained therein the diffusion device characterized as having at least one interior reservoir accessible through a penetrable external device layer comprising one or more ports installed or installable to the external device layer, and an agent delivery mechanism coupled to at least one of the ports.

Abstract: A package for a diffusion device including more than one device layer and at least one reservoir containing a therapeutic agent, the package including at least one packaging layer, and at least one sealing surface disposed along one or more edges of the at least one packaging layer. The package is characterized in that the sealing surface engages one of a device layer or another packaging layer to form the package.

Abstract: A diffusing device for treating tissue has multiple cells arranged in a cell layer, the cells filled with or charged with a therapeutic agent, an occlusive layer in direct communication with the cell layer, and a diffusion layer in direct communication with the cell layer. In use the diffusing device is sealed peripherally about an area of tissue and therapeutic agent is released from the cells through the diffusion layer based on the diffusion properties of the diffusion layer.

Abstract: An oxygen-producing device for aiding in treatment of diseases and conditions of the human eye has a power supply with an electrical output, and at least one pair of electrodes, one electrode of the pair coupled to the electrically positive output and the other coupled to the electrically negative output. The device is characterized in that the device is sized to occupy no more than one fortieth of the volume of an average human eye, and the power supply is enabled to provide a DC voltage of at least 1.2 volts over a period of time.