Patents by Inventor Amiel A. HUNDLEY

Amiel A. HUNDLEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR INDUCIBLE ALTERNATIVE SPLICING REGULATION OF GENE EXPRESSION
    Publication number: 20230340498
    Abstract: Provided herein are chimeric minigenes, where the alternative splicing of the minigene determines whether an encoded gene is expressed. In particular, the minigenes are alternatively spliced in response to splicing modulator dmgs, such that the encoded gene is only expressed in the present of the splicing modulator dmg. The encoded gene may encode an inhibitory RNA, a CRISPR-Cas9 protein, a transactivator, or a therapeutic protein.
    Type: Application
    Filed: February 12, 2021
    Publication date: October 26, 2023
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Beverly L. DAVIDSON, Alejandro Mas MONTEYS, Amiel A. HUNDLEY, Paul T. RANUM