Patents by Inventor Amihay Freeman

Amihay Freeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10016154
    Abstract: A sensor system is disclosed. The system comprises: a solid substrate having a front side and a back side, a sensing assembly formed on the front side and being configured to provide electrochemical sensing, a plurality of electrical contacts, formed on the back side and being in electrical communication with the sensing assembly via a plurality of interconnects passing through the substrate and extending at least from the front side to the back side, and a mounting member configured for mounting the back side onto a tip of a movable device.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: July 10, 2018
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Yosi Shacham-Diamand, Heftsi Ragones, Amihay Freeman, David Schreiber
  • Patent number: 9155828
    Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: October 13, 2015
    Assignees: Ramot at Tel-Aviv University Ltd., EnzySurge Ltd.
    Inventors: Amihay Freeman, Eran Hirszowicz, Michal Beeri-Lipperman
  • Patent number: 9057088
    Abstract: Silver-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein and a process for preparing same are disclosed. Further disclosed are modified proteins which have a reducing moiety attached to the surface thereof and a process for preparing same. The modified proteins can be utilized for obtaining the silver-coated proteins. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active silver-coated hydrogen peroxide producing enzymes such as glucose oxidase. Further disclosed are conductive elements that comprise the silver-coated proteins disclosed herein and electronic circuits containing same. Further disclosed are electrodes having the silver-coated proteins deposited thereon and biosensor systems utilizing same for determining a level of an analyte in a liquid sample.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: June 16, 2015
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Amihay Freeman, Yosi Shacham-Diamand, Hila Moscovich-Dagan, Noa Hadar
  • Publication number: 20150150493
    Abstract: A sensor system is disclosed. The system comprises: a solid substrate having a front side and a back side, a sensing assembly formed on the front side and being configured to provide electrochemical sensing, a plurality of electrical contacts, formed on the back side and being in electrical communication with the sensing assembly via a plurality of interconnects passing through the substrate and extending at least from the front side to the back side, and a mounting member configured for mounting the back side onto a tip of a movable device.
    Type: Application
    Filed: February 5, 2015
    Publication date: June 4, 2015
    Inventors: Yosi SHACHAM-DIAMAND, Heftsi RAGONES, Amihay FREEMAN, David SCHREIBER
  • Patent number: 8968794
    Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: March 3, 2015
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Noa Hadar, Amihay Freeman
  • Patent number: 8968793
    Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: March 3, 2015
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Noa Hadar, Amihay Freeman
  • Patent number: 8337837
    Abstract: The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.
    Type: Grant
    Filed: January 16, 2012
    Date of Patent: December 25, 2012
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Amihay Freeman, Noa Hadar
  • Patent number: 8197808
    Abstract: The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: June 12, 2012
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Amihay Freeman, Noa Hadar
  • Publication number: 20120114631
    Abstract: The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.
    Type: Application
    Filed: January 16, 2012
    Publication date: May 10, 2012
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Amihay FREEMAN, Noa Hadar
  • Patent number: 8128589
    Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: March 6, 2012
    Assignees: Ramot at Tel-Aviv University Ltd., EnzySurge Ltd.
    Inventors: Amihay Freeman, Eran Hirszowicz, Michal Be'eri-Lipperman
  • Publication number: 20120004627
    Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.
    Type: Application
    Filed: July 18, 2011
    Publication date: January 5, 2012
    Applicants: EnzySurge Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Amihay FREEMAN, Eran HIRSZOWICZ, Michal BE'ERI-LIPPERMAN
  • Publication number: 20110159062
    Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.
    Type: Application
    Filed: March 1, 2011
    Publication date: June 30, 2011
    Inventors: Noa HADAR, Amihay FREEMAN
  • Patent number: 7825104
    Abstract: Phenylboronic acid and water soluble derivatives thereof and related boronic acid compounds are used for treating fungal and bacterial infections.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: November 2, 2010
    Assignee: Ramot at Tel Aviv University Ltd.
    Inventors: Amihay Freeman, Rina Segal, Yael Dror
  • Publication number: 20100203158
    Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.
    Type: Application
    Filed: February 11, 2010
    Publication date: August 12, 2010
    Applicant: Ramot At Tel Aviv University Ltd.
    Inventors: Noa HADAR, Amihay Freeman
  • Publication number: 20090291070
    Abstract: Silver-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein and a process for preparing same are disclosed. Further disclosed are modified proteins which have a reducing moiety attached to the surface thereof and a process for preparing same. The modified proteins can be utilized for obtaining the silver-coated proteins. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active silver-coated hydrogen peroxide producing enzymes such as glucose oxidase. Further disclosed are conductive elements that comprise the silver-coated proteins disclosed herein and electronic circuits containing same. Further disclosed are electrodes having the silver-coated proteins deposited thereon and biosensor systems utilizing same for determining a level of an analyte in a liquid sample.
    Type: Application
    Filed: January 26, 2006
    Publication date: November 26, 2009
    Applicant: Ramot At Tel Aviv Univerysity Ltd.
    Inventors: Amihay Freeman, Yosi Shacham-Diamand, Hila Moscovich-Dagan, Noa Hadar
  • Publication number: 20090220483
    Abstract: The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.
    Type: Application
    Filed: December 27, 2006
    Publication date: September 3, 2009
    Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Amihay Freeman, Noa Hadar
  • Publication number: 20090127112
    Abstract: Metal-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein, a process and intermediates for preparing same are disclosed. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active metal-coated proteins. Conductive elements, electronic circuits containing same, electrodes and biosensor systems utilizing same, and imaging probes, all containing the metal-coated proteins, are also disclosed.
    Type: Application
    Filed: May 18, 2006
    Publication date: May 21, 2009
    Applicant: Ramot At Tel Aviv University Ltd.
    Inventors: Amihay Freeman, Yosi Shacham-Diamand, Sefi Vernick, Hila Moscovich-Dagan
  • Patent number: 7364565
    Abstract: Method and device, including a uniquely operative applicator, and pharmaceutical compositions, for the controlled, non-surgical removal and retrieval of cells from a variety of skin lesions and tissue surfaces are disclosed. A synergistic effect of proteolytic digestion of the intracellular matrix and “stripping” flow is achieved by treating a defined area with a controlled, continuous stream of proteolytic enzyme solution, causing gentle but effective tissue erosion. Isolated cells from the skin lesion and/or tissue surface may be collected from the protease solution stream for histological analysis and/or cell culture, affording a method of “enzymatic biopsy”. The protease solution may be supplemented with anesthetics, coagulants, anticoagulants and antibiotics to decrease the discomfort, erythema, bleeding, risk of infection and scarring traditionally associated with surgical treatment of skin lesions.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: April 29, 2008
    Assignee: Ramot at Tel Aviv University Ltd.
    Inventor: Amihay Freeman
  • Publication number: 20070041960
    Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.
    Type: Application
    Filed: July 25, 2006
    Publication date: February 22, 2007
    Inventors: Amihay Freeman, Eran Hirszowicz, Michal Be'eri-Lipperman
  • Publication number: 20040220146
    Abstract: Phenylboronic acid and water soluble derivatives thereof and related boronic acid compounds are used for treating fungal and bacterial infections.
    Type: Application
    Filed: June 15, 2004
    Publication date: November 4, 2004
    Inventors: Amihay Freeman, Rina Segal, Yael Dror