Patents by Inventor Amihay Freeman
Amihay Freeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10016154Abstract: A sensor system is disclosed. The system comprises: a solid substrate having a front side and a back side, a sensing assembly formed on the front side and being configured to provide electrochemical sensing, a plurality of electrical contacts, formed on the back side and being in electrical communication with the sensing assembly via a plurality of interconnects passing through the substrate and extending at least from the front side to the back side, and a mounting member configured for mounting the back side onto a tip of a movable device.Type: GrantFiled: February 5, 2015Date of Patent: July 10, 2018Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Yosi Shacham-Diamand, Heftsi Ragones, Amihay Freeman, David Schreiber
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Patent number: 9155828Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.Type: GrantFiled: July 18, 2011Date of Patent: October 13, 2015Assignees: Ramot at Tel-Aviv University Ltd., EnzySurge Ltd.Inventors: Amihay Freeman, Eran Hirszowicz, Michal Beeri-Lipperman
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Patent number: 9057088Abstract: Silver-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein and a process for preparing same are disclosed. Further disclosed are modified proteins which have a reducing moiety attached to the surface thereof and a process for preparing same. The modified proteins can be utilized for obtaining the silver-coated proteins. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active silver-coated hydrogen peroxide producing enzymes such as glucose oxidase. Further disclosed are conductive elements that comprise the silver-coated proteins disclosed herein and electronic circuits containing same. Further disclosed are electrodes having the silver-coated proteins deposited thereon and biosensor systems utilizing same for determining a level of an analyte in a liquid sample.Type: GrantFiled: January 26, 2006Date of Patent: June 16, 2015Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Amihay Freeman, Yosi Shacham-Diamand, Hila Moscovich-Dagan, Noa Hadar
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Publication number: 20150150493Abstract: A sensor system is disclosed. The system comprises: a solid substrate having a front side and a back side, a sensing assembly formed on the front side and being configured to provide electrochemical sensing, a plurality of electrical contacts, formed on the back side and being in electrical communication with the sensing assembly via a plurality of interconnects passing through the substrate and extending at least from the front side to the back side, and a mounting member configured for mounting the back side onto a tip of a movable device.Type: ApplicationFiled: February 5, 2015Publication date: June 4, 2015Inventors: Yosi SHACHAM-DIAMAND, Heftsi RAGONES, Amihay FREEMAN, David SCHREIBER
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Patent number: 8968794Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.Type: GrantFiled: March 1, 2011Date of Patent: March 3, 2015Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Noa Hadar, Amihay Freeman
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Patent number: 8968793Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.Type: GrantFiled: February 11, 2010Date of Patent: March 3, 2015Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Noa Hadar, Amihay Freeman
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Patent number: 8337837Abstract: The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.Type: GrantFiled: January 16, 2012Date of Patent: December 25, 2012Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Amihay Freeman, Noa Hadar
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Patent number: 8197808Abstract: The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.Type: GrantFiled: December 27, 2006Date of Patent: June 12, 2012Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Amihay Freeman, Noa Hadar
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Publication number: 20120114631Abstract: The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.Type: ApplicationFiled: January 16, 2012Publication date: May 10, 2012Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Amihay FREEMAN, Noa Hadar
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Patent number: 8128589Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.Type: GrantFiled: July 25, 2006Date of Patent: March 6, 2012Assignees: Ramot at Tel-Aviv University Ltd., EnzySurge Ltd.Inventors: Amihay Freeman, Eran Hirszowicz, Michal Be'eri-Lipperman
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Publication number: 20120004627Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.Type: ApplicationFiled: July 18, 2011Publication date: January 5, 2012Applicants: EnzySurge Ltd., Ramot at Tel-Aviv University Ltd.Inventors: Amihay FREEMAN, Eran HIRSZOWICZ, Michal BE'ERI-LIPPERMAN
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Publication number: 20110159062Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.Type: ApplicationFiled: March 1, 2011Publication date: June 30, 2011Inventors: Noa HADAR, Amihay FREEMAN
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Patent number: 7825104Abstract: Phenylboronic acid and water soluble derivatives thereof and related boronic acid compounds are used for treating fungal and bacterial infections.Type: GrantFiled: July 23, 2002Date of Patent: November 2, 2010Assignee: Ramot at Tel Aviv University Ltd.Inventors: Amihay Freeman, Rina Segal, Yael Dror
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Publication number: 20100203158Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.Type: ApplicationFiled: February 11, 2010Publication date: August 12, 2010Applicant: Ramot At Tel Aviv University Ltd.Inventors: Noa HADAR, Amihay Freeman
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Publication number: 20090291070Abstract: Silver-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein and a process for preparing same are disclosed. Further disclosed are modified proteins which have a reducing moiety attached to the surface thereof and a process for preparing same. The modified proteins can be utilized for obtaining the silver-coated proteins. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active silver-coated hydrogen peroxide producing enzymes such as glucose oxidase. Further disclosed are conductive elements that comprise the silver-coated proteins disclosed herein and electronic circuits containing same. Further disclosed are electrodes having the silver-coated proteins deposited thereon and biosensor systems utilizing same for determining a level of an analyte in a liquid sample.Type: ApplicationFiled: January 26, 2006Publication date: November 26, 2009Applicant: Ramot At Tel Aviv Univerysity Ltd.Inventors: Amihay Freeman, Yosi Shacham-Diamand, Hila Moscovich-Dagan, Noa Hadar
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Publication number: 20090220483Abstract: The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.Type: ApplicationFiled: December 27, 2006Publication date: September 3, 2009Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.Inventors: Amihay Freeman, Noa Hadar
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Publication number: 20090127112Abstract: Metal-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein, a process and intermediates for preparing same are disclosed. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active metal-coated proteins. Conductive elements, electronic circuits containing same, electrodes and biosensor systems utilizing same, and imaging probes, all containing the metal-coated proteins, are also disclosed.Type: ApplicationFiled: May 18, 2006Publication date: May 21, 2009Applicant: Ramot At Tel Aviv University Ltd.Inventors: Amihay Freeman, Yosi Shacham-Diamand, Sefi Vernick, Hila Moscovich-Dagan
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Patent number: 7364565Abstract: Method and device, including a uniquely operative applicator, and pharmaceutical compositions, for the controlled, non-surgical removal and retrieval of cells from a variety of skin lesions and tissue surfaces are disclosed. A synergistic effect of proteolytic digestion of the intracellular matrix and “stripping” flow is achieved by treating a defined area with a controlled, continuous stream of proteolytic enzyme solution, causing gentle but effective tissue erosion. Isolated cells from the skin lesion and/or tissue surface may be collected from the protease solution stream for histological analysis and/or cell culture, affording a method of “enzymatic biopsy”. The protease solution may be supplemented with anesthetics, coagulants, anticoagulants and antibiotics to decrease the discomfort, erythema, bleeding, risk of infection and scarring traditionally associated with surgical treatment of skin lesions.Type: GrantFiled: January 27, 2004Date of Patent: April 29, 2008Assignee: Ramot at Tel Aviv University Ltd.Inventor: Amihay Freeman
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Publication number: 20070041960Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.Type: ApplicationFiled: July 25, 2006Publication date: February 22, 2007Inventors: Amihay Freeman, Eran Hirszowicz, Michal Be'eri-Lipperman
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Publication number: 20040220146Abstract: Phenylboronic acid and water soluble derivatives thereof and related boronic acid compounds are used for treating fungal and bacterial infections.Type: ApplicationFiled: June 15, 2004Publication date: November 4, 2004Inventors: Amihay Freeman, Rina Segal, Yael Dror