Abstract: The present disclosure relates to an apparatus (1) for fractional treatment of skin tissue of a patient. The apparatus (1) comprises a handpiece with a housing, at least one first electrode (11) and at least one second electrode (15) located on a distal end of the handpiece and an energy source, which is connected to said at least one first (11) and said at least one second (15) electrode. The apparatus (1) is adapted for applying radio frequency (RF) energy to the tissue. The at least one second electrode (15) is arranged on a base plate (13) and the at least one first electrode (11) is or comprises a pin or a needle (11), in particular a microneedle, which penetrates the base plate (13) through a through hole (17).

Abstract: The present invention relates to an apparatus for fractional treatment of skin tissue of a patient comprising a handpiece, at least one first electrode and at least one second electrode, arranged on a base plate for applying radio frequency energy, to at least one layer of the skin, wherein the apparatus is adapted to apply electrical energy to the skin tissue with a first pulse and a second pulse following the first pulse, with the first pulse being a low energy level pulse and the second pulse being a high energy level pulse having a higher energy level than the low energy level pulse.

Abstract: The present invention relates to an apparatus for fractional treatment of skin tissue of a patient comprising a handpiece, at least one first electrode and at least one second electrode, arranged on a base plate for applying radio frequency energy, to at least one layer of the skin, wherein the apparatus is adapted to apply electrical energy to the skin tissue with a first pulse and a second pulse following the first pulse, with the first pulse being a low energy level pulse and the second pulse being a high energy level pulse having a higher energy level than the low energy level pulse.

Abstract: The present invention relates to an apparatus for fractional treatment of skin tissue of a patient comprising a handpiece, at least one first electrode and at least one second electrode, arranged on a base plate for applying radio frequency energy, to at least one layer of the skin, wherein the apparatus is adapted to apply electrical energy to the skin tissue with a first pulse and a second pulse following the first pulse, with the first pulse being a low energy level pulse and the second pulse being a high energy level pulse having a higher energy level than the low energy level pulse.

Abstract: The present disclosure relates to an apparatus (1) for fractional treatment of skin tissue of a patient. The apparatus (1) comprises a handpiece with a housing, at least one first electrode (11) and at least one second electrode (15) located on a distal end of the handpiece and an energy source, which is connected to said at least one first (11) and said at least one second (15) electrode. The apparatus (1) is adapted for applying radio frequency (RF) energy to the tissue. The at least one second electrode (15) is arranged on a base plate (13) and the at least one first electrode (11) is or comprises a pin or a needle (11), in particular a microneedle, which penetrates the base plate (13) through a through hole (17).

Abstract: A system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and methods of use thereof employ an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.

Abstract: The present invention relates to methods of transdermal delivery of pharmaceutical agents. In particular, the present invention relates to a method for transdermal delivery by generating micro-channels on the skin of a subject and delivering iontophoretically a pharmaceutical agent through the micro-channels. The method provides synergistic transdermal delivery of such pharmaceutical agents.

Abstract: The present invention relates to a system for intradermal or transdermal delivery of oligonucleotides or polynucleotides and to methods of use thereof. Particularly, the present invention relates to a system comprising an apparatus that generates micro-channels in the skin of a subject in conjunction with a pharmaceutical composition comprising an oligonucleotide or polynucleotide, wherein the oligonucleotide or polynucleotide can be delivered into the organism through the micro-channels. The system and methods of the present invention achieve expression of target proteins encoded by the polynucleotides, and hence are useful in immunization and gene therapy.

Abstract: The present invention relates to methods of transdermal delivery of pharmaceutical agents. In particular, the present invention relates to a method for transdermal delivery by generating micro-channels on the skin of a subject and delivering iontophoretically a pharmaceutical agent through the micro-channels. The method provides synergistic transdermal delivery of such pharmaceutical agents.

Abstract: The present invention relates to methods and device for transdermal immunization. More particularly, the invention relates to a device for effective topical administration of antigens comprising an apparatus that generates micro-channels in the skin of a subject. The delivery system is useful for immunization against bacterial, viral, and fungal antigens and for treating tumors and allergies.