Abstract: An in vitro method for detecting presence of cancer includes obtaining a single hair sample. An x-ray beam is emitted from a source towards the hair sample. A small angle X-ray scattering (SAXS) intensity profile is generated after the x-ray beam hits the hair sample. The SAXS profile is received on a detector to obtain SAXS data, which is desmeared and Kratky Analysis is performed. A relative estimation of peak area under 1.38 nm?1 to 0.89 nm?1 from keratin and lipid content in the hair sample is performed to obtain R and is corrected by dividing by D, thickness of the hair. R? is computed using formula: 10×R2/(D?R). The value of R? is compared with clinically validated samples. If R? value is below 0.7, it indicates the presence of cancer and if it is above 0.8, it indicates absence of cancer.

Abstract: The present invention relates to an in-vitro method of detecting Mtb infection by using SAXS profile of hair sample. The invention is an approach to overcome the problem of non-invasively and cost-effectively yet reliably diagnosing presence of active tuberculosis in the patient. There would be no risk to the sample handlers getting infected from the sample, cross-contamination of samples, low cost and quick turn-around time of diagnosis.

Abstract: The present application provides an in vitro method for detecting presence of cancer by analyzing small angle X-ray scattering (SAXS) of a single hair by automated data analysis using end user or in-house X-ray source. Specifically, the present methodology provides a method which also provides steps to allow correction for hair thickness and provide a quantitative view on the cancer status of the subject.

Abstract: The present invention relates to an in-vitro method of detecting Mtb infection by using SAXS profile of hair sample. The invention is an approach to overcome the problem of non-invasively and cost-effectively yet reliably diagnosing presence of active tuberculosis in the patient. There would be no risk to the sample handlers getting infected from the sample, cross-contamination of samples, low cost and quick turn-around time of diagnosis.