Patents by Inventor Amir H. Hoveyda
Amir H. Hoveyda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11492370Abstract: Method of making a cross metathesis product, the method comprising at least step (X) or step (Y): (X) reacting in a cross metathesis reaction a first compound comprising a terminal olefinic group with a second compound comprising a terminal olefinic group, wherein the first and the second compound may be identical or may be different from one another; or (Y) reacting in a ring-closing metathesis reaction two terminal olefinic groups which are comprised in a third compound; wherein the reacting in step (X) or step (Y) is performed in the presence of a ruthenium carbene complex comprising a [Ru?C]-moiety and an internal olefin.Type: GrantFiled: July 20, 2018Date of Patent: November 8, 2022Assignee: Trustees of Boston CollegeInventors: Amir H. Hoveyda, Chaofan Xu, Xiao Shen
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Patent number: 11332426Abstract: Method of forming a trisubstituted ethylene compound, the method comprising: (A) providing a trisubstituted ethylene compound bearing a first, a second and a third substituent, in which the first and the second substituent are bound to the one olefinic carbon atom and are different from one another; (B) providing a monosubstituted ethylene compound or a disubstituted ethylene compound in which the substituents are vicinally bound to the olefinic carbon atoms, bearing at least a fourth substituent, respectively; (C) subjecting the trisubstituted ethylene compound provided in step (A) to a cross-metathesis reaction with olefin provided in step (B) to form said trisubstituted ethylene, wherein the cross-metathesis reaction is catalysed by a transition metal complex bearing ligands from which one ligand is a carbene ligand, wherein the carbene complex is characterized by a M=C moiety, wherein M is the transition metal; and wherein the reaction proceeds stereoselectively.Type: GrantFiled: September 21, 2018Date of Patent: May 17, 2022Assignees: Trustees of Boston College, Massachusetts Institute of TechnologyInventors: Amir H. Hoveyda, Thach T. Nguyen, Ming Joo Koh, Chaofan Xu, Sebastian Torker, Richard Royce Schrock
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Patent number: 11020730Abstract: The present disclosure provides compounds, compositions, and methods for preparing alkenyl halides and/or haloalkyl-substituted olefins with Z-selectivity. The methods are particularly useful for preparing alkenyl fluorides such as CF3-substituted olefins by means of cross-metathesis reactions using halogen-containing molybdenum and tungsten complexes.Type: GrantFiled: July 14, 2017Date of Patent: June 1, 2021Assignees: Massachusetts Institute of Technology, Trustees of Boston CollegeInventors: Amir H. Hoveyda, Ming Joo Koh, Thach T. Nguyen, Richard R. Schrock, Jakub Hyvl
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Publication number: 20200369697Abstract: The invention relates to molybdenum oxo alkylidene complexes of formula (I) wherein R1, R2, R3, R4, R5 and n are defined in the description, methods of making same and use thereof in metathesis reactions.Type: ApplicationFiled: February 8, 2019Publication date: November 26, 2020Inventors: Richard Royce Schrock, Konstantin V. Bukhryakov, Amir H. Hoveyda
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Publication number: 20200270194Abstract: Method of forming a trisubstituted ethylene compound, the method comprising: (A) providing a trisubstituted ethylene compound bearing a first, a second and a third substituent, in which the first and the second substituent are bound to the one olefinic carbon atom and are different from one another; (B) providing a monosubstituted ethylene compound or a disubstituted ethylene compound in which the substituents are vicinally bound to the olefinic carbon atoms, bearing at least a fourth substituent, respectively; (C) subjecting the trisubstituted ethylene compound provided in step (A) to a cross-metathesis reaction with olefin provided in step (B) to form said trisubstituted ethylene, wherein the cross-metathesis reaction is catalysed by a transition metal complex bearing ligands from which one ligand is a carbene ligand, wherein the carbene complex is characterized by a M?C moiety, wherein M is the transition metal; and wherein the reaction proceeds stereoselectively.Type: ApplicationFiled: September 21, 2018Publication date: August 27, 2020Inventors: Amir H. Hoveyda, Thach T. Nguyen, Ming Joo Koh, Chaofan Xu, Sebastian Torker, Richard Royce Schrock
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Publication number: 20200123197Abstract: Method of making a cross metathesis product, the method comprising at least step (X) or step (Y): (X) reacting in a cross metathesis reaction a first compound comprising a terminal olefinic group with a second compound comprising a terminal olefinic group, wherein the first and the second compound may be identical or may be different from one another; or (Y) reacting in a ring-closing metathesis reaction two terminal olefinic groups which are comprised in a third compound; wherein the reacting in step (X) or step (Y) is performed in the presence of a ruthenium carbene complex comprising a [Ru?C]-moiety and an internal olefin.Type: ApplicationFiled: July 20, 2018Publication date: April 23, 2020Inventors: Amir H. Hoveyda, Chaofan Xu, Xiao Shen
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Patent number: 10584141Abstract: Highly active, recoverable and recyclable transition metal-based metathesis catalysts and their organometallic complexes including dendrimeric complexes are disclosed, including a Ru complex bearing a 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene and styrenyl ether ligand. The heterocyclic ligand significantly enhances the catalytic activity, and the styrenyl ether allows for the easy recovery of the Ru complex. Derivatized catalysts capable of being immobilized on substrate surfaces are also disclosed. The present catalysts can be used to catalyze ring-closing metathesis (RCM), ring-opening (ROM) and cross metatheses (CM) reactions, and promote the efficient formation of various trisubstituted olefins at ambient temperature in high yield.Type: GrantFiled: June 14, 2019Date of Patent: March 10, 2020Assignee: THE TRUSTEES OF BOSTON COLLEGEInventors: Amir H. Hoveyda, Jason Kingsbury, Steven Garber, Brian L. Gray, John T. Fourkas
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Catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods
Patent number: 10569261Abstract: The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.Type: GrantFiled: June 6, 2017Date of Patent: February 25, 2020Assignees: Trustees of Boston College, Massachusetts Institute of TechnologyInventors: Steven J. Malcolmson, Amir H. Hoveyda, Simon J. Meek, Richard R. Schrock -
Publication number: 20190314799Abstract: The present disclosure provides compounds, compositions, and methods for preparing alkenyl halides and/or haloalkyl-substituted olefins with Z-selectivity. The methods are particularly useful for preparing alkenyl fluorides such as CF3-substituted olefins by means of cross-metathesis reactions using halogen-containing molybdenum and tungsten complexes.Type: ApplicationFiled: July 14, 2017Publication date: October 17, 2019Inventors: Amir H. Hoveyda, Ming Joo Koh, Thach T. Nguyen, Richard R. Schrock, Jakub Hyvl
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Publication number: 20190309001Abstract: Highly active, recoverable and recyclable transition metal-based metathesis catalysts and their organometallic complexes including dendrimeric complexes are disclosed, including a Ru complex bearing a 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene and styrenyl ether ligand. The heterocyclic ligand significantly enhances the catalytic activity, and the styrenyl ether allows for the easy recovery of the Ru complex. Derivatized catalysts capable of being immobilized on substrate surfaces are also disclosed. The present catalysts can be used to catalyze ring-closing metathesis (RCM), ring-opening (ROM) and cross metatheses (CM) reactions, and promote the efficient formation of various trisubstituted olefins at ambient temperature in high yield.Type: ApplicationFiled: June 14, 2019Publication date: October 10, 2019Inventors: Amir H. Hoveyda, Jason Kingsbury, Steven Garber, Brian L. Gray, John T. Fourkas
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Patent number: 10336781Abstract: Highly active, recoverable and recyclable transition metal-based metathesis catalysts and their organometallic complexes including dendrimeric complexes are disclosed, including a Ru complex bearing a 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene and styrenyl ether ligand. The heterocyclic ligand significantly enhances the catalytic activity, and the styrenyl ether allows for the easy recovery of the Ru complex. Derivatized catalysts capable of being immobilized on substrate surfaces are also disclosed. The present catalysts can be used to catalyze ring-closing metathesis (RCM), ring-opening (ROM) and cross metatheses (CM) reactions, and promote the efficient formation of various trisubstituted olefins at ambient temperature in high yield.Type: GrantFiled: October 21, 2015Date of Patent: July 2, 2019Assignee: THE TRUSTEES OF BOSTON COLLEGEInventors: Amir H. Hoveyda, Jason Kingsbury, Steven Garber, Brian L. Gray, John T. Fourkas
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Patent number: 10173208Abstract: The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.Type: GrantFiled: January 5, 2017Date of Patent: January 8, 2019Assignees: Massachusetts Institute of Technology, Trustees of Boston CollegeInventors: Richard R. Schrock, Annie J. King, Yu Zhao, Margaret M. Flook, Amir H. Hoveyda
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Publication number: 20180127447Abstract: The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and Z-selectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and E-selectivity. In some embodiments, provided technologies are particularly useful for preparing alkenyl fluorides. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-a. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-b.Type: ApplicationFiled: November 17, 2017Publication date: May 10, 2018Inventors: Amir H. Hoveyda, Hanmo Zhang, Ming Joo Koh, Richard Royce Schrock
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Patent number: 9938253Abstract: The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, provided compounds promote highly efficient and highly Z-selective metathesis. In some embodiments, provided compounds and methods are particularly useful for producing allyl alcohols. In some embodiments, provided compounds have the structure of formula I. In some embodiments, provided compounds comprise ruthenium, and a ligand bonded to ruthenium through a sulfur atom.Type: GrantFiled: June 12, 2014Date of Patent: April 10, 2018Assignee: Trustees of Boston CollegeInventors: Amir H. Hoveyda, R. Kashif M. Khan, Sebastian Torker, Ming Joo Koh
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Patent number: 9850268Abstract: The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and Z-selectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and E-selectivity. In some embodiments, provided technologies are particularly useful for preparing alkenyl fluorides. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-a. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-b.Type: GrantFiled: November 5, 2015Date of Patent: December 26, 2017Assignees: Trustees of Boston College, Massachusetts Institute of TechnologyInventors: Amir H. Hoveyda, Hanmo Zhang, Ming Joo Koh, Richard Royce Schrock
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CATALYSTS FOR METATHESIS REACTIONS INCLUDING ENANTIOSELECTIVE OLEFIN METATHESIS, AND RELATED METHODS
Publication number: 20170333887Abstract: The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.Type: ApplicationFiled: June 6, 2017Publication date: November 23, 2017Inventors: Steven J. Malcolmson, Amir H. Hoveyda, Simon J. Meek, Richard R. Schrock -
Patent number: 9771386Abstract: The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis.Type: GrantFiled: August 5, 2016Date of Patent: September 26, 2017Assignees: Massachusetts Institute of Technology, Trustees of Boston CollegeInventors: Amir H. Hoveyda, Miao Yu, Chenbo Wang, Richard R. Schrock
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Patent number: 9713808Abstract: The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.Type: GrantFiled: July 13, 2015Date of Patent: July 25, 2017Assignees: Massachusetts Institute of Technology, Trustees of Boston CollegeInventors: Richard R. Schrock, Annie J. King, Yu Zhao, Margaret M. Flook, Amir H. Hoveyda
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Catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods
Patent number: 9687834Abstract: The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.Type: GrantFiled: January 23, 2009Date of Patent: June 27, 2017Assignees: Trustees of Boston College, Massachusetts Institute of TechnologyInventors: Steven J. Malcolmson, Amir H. Hoveyda, Simon J. Meek, Richard R. Schrock -
Publication number: 20170129910Abstract: The present invention relates generally to olefin metathesis. In some embodiments, the present invention provides methods for Z-selective ring-closing metathesis.Type: ApplicationFiled: August 5, 2016Publication date: May 11, 2017Inventors: Amir H. Hoveyda, Miao Yu, Chenbo Wang, Richard R. Schrock