Patents by Inventor Amir Sagi

Amir Sagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Functional sex-reversal of decapod crustacean females
    Patent number: 11624052
    Abstract: The present invention provides a primary cell culture which combines a cell culture medium and cells derived from a hypertrophied androgenic gland (AG) of a decapod crustacean. The invention also provides methods for obtaining an all-female progeny by initially injecting/transplanting the primary cell culture to a genetic-female to obtain a male-Neo-male.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: April 11, 2023
    Assignee: ENZOOTIC HOLDINGS LTD.
    Inventors: Assaf Shechter, Ohad Rosen, Amir Sagi
  • DELIVERY PEPTIDES AND METHODS OF USING THE SAME
    Publication number: 20220204563
    Abstract: The present invention is directed to a peptide, and methods of using the same such as in the delivery of an agent into a cell, or modification of a cell.
    Type: Application
    Filed: February 15, 2022
    Publication date: June 30, 2022
    Inventors: Isam KHALAILA, Amir SAGI, Shany COHEN
  • WW homogametic male decapod crustacean and methods of using the same
    Patent number: 10791721
    Abstract: The present invention provides an all-female progeny of a decapod crustacean. The invention further provides the newly created: WW homogametic Neo-male decapod crustacean and WW homogametic female decapod crustacean. The crossing of WW homogametic Neo-male decapod crustacean and WW homogametic female decapod crustacean resulted in a 100% homogametic all-WW female progeny.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: October 6, 2020
    Assignee: ENZOOTIC HOLDINGS LTD.
    Inventors: Assaf Shechter, Ohad Rosen, Amir Sagi
  • Amorphous calcium carbonate for the treatment of calcium malabsorption and metabolic bone disorders
    Patent number: 10688124
    Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: June 23, 2020
    Assignee: AMORPHICAL LTD
    Inventors: Amir Sagi, Assaf Shechter, Galit Shaltiel-Gold, Michal Daniely, Oren Meiron
  • FUNCTIONAL SEX-REVERSAL OF DECAPOD CRUSTACEAN FEMALES
    Publication number: 20200190467
    Abstract: The present invention provides a primary cell culture which combines a cell culture medium and cells derived from a hypertrophied androgenic gland (AG) of a decapod crustacean. The invention also provides methods for obtaining an all-female progeny by initially injecting/transplanting the primary cell culture to a genetic-female to obtain a male-Neo-male.
    Type: Application
    Filed: February 24, 2020
    Publication date: June 18, 2020
    Inventors: Assaf SHECHTER, Ohad ROSEN, Amir SAGI
  • Functional sex-reversal of decapod crustacean females
    Patent number: 10570368
    Abstract: The present invention provides a primary cell culture which combines a cell culture medium and cells derived from a hypertrophied androgenic gland (AG) of a decapod crustacean. The invention also provides methods for obtaining an all-female progeny by initially injecting/transplanting the primary cell culture to a genetic-female to obtain a male-Neo-male.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: February 25, 2020
    Assignee: ENZOOTIC HOLDINGS LTD.
    Inventors: Assaf Shechter, Ohad Rosen, Amir Sagi
  • Stable amorphous calcium carbonate comprising synthetic phosphorylated peptides
    Patent number: 10328100
    Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: June 25, 2019
    Assignee: AMORPHICAL LTD.
    Inventors: Shmuel Bentov, Amir Sagi, Amir Berman, Assaf Shechter
  • AMORPHOUS CALCIUM CARBONATE FOR THE TREATMENT OF CALCIUM MALABSORPTION AND METABOLIC BONE DISORDERS
    Publication number: 20190022133
    Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.
    Type: Application
    Filed: July 31, 2018
    Publication date: January 24, 2019
    Inventors: Amir SAGI, Assaf SHECHTER, Galit SHALTIEL-GOLD, Michal DANIELY, Oren MEIRON
  • A WW HOMOGAMETIC MALE DECAPOD CRUSTACEAN AND METHODS OF USING THE SAME
    Publication number: 20180317467
    Abstract: The present invention provides an all-female progeny of a decapod crustacean. The invention further provides the newly created: WW homogametic Neo-male decapod crustacean and WW homogametic female decapod crustacean. The crossing of WW homogametic Neo-male decapod crustacean and WW homogametic female decapod crustacean resulted in a 100% homogametic all-WW female progeny.
    Type: Application
    Filed: November 10, 2016
    Publication date: November 8, 2018
    Inventors: Assaf SHECHTER, Ohad ROSEN, Amir SAGI
  • Amorphous calcium carbonate for the treatment of calcium malabsorption and metabolic bone disorders
    Patent number: 10064890
    Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: September 4, 2018
    Assignee: AMORPHICAL LTD.
    Inventors: Amir Sagi, Assaf Shechter, Galit Shaltiel-Gold, Michal Daniely, Oren Meiron
  • FUNCTIONAL SEX-REVERSAL OF DECAPOD CRUSTACEAN FEMALES
    Publication number: 20170313975
    Abstract: The present invention provides a primary cell culture which combines a cell culture medium and cells derived from a hypertrophied androgenic gland (AG) of a decapod crustacean. The invention also provides methods for obtaining an all-female progeny by initially injecting/transplanting the primary cell culture to a genetic-female to obtain a male-Neo-male.
    Type: Application
    Filed: November 13, 2015
    Publication date: November 2, 2017
    Inventors: Assaf SHECHTER, Ohad ROSEN, Amir SAGI
  • STABLE AMORPHOUS CALCIUM CARBONATE COMPRISING SYNTHETIC PHOSPHORYLATED PEPTIDES
    Publication number: 20160045546
    Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.
    Type: Application
    Filed: June 19, 2015
    Publication date: February 18, 2016
    Applicant: AMORPHICAL LTD.
    Inventors: Shmuel BENTOV, Amir SAGI, Amir BERMAN, Assaf SHECHTER
  • ORALLY-ADMINISTRABLE COMPOSITIONS COMPRISING STABLE AMORPHOUS CALCIUM CARBONATE
    Publication number: 20150366903
    Abstract: The present invention provides orally-administrable compositions comprising stable amorphous calcium carbonate (ACC). The compositions are preferably prepared as solid dosage forms such as tablets, capsules and powders. The present invention further provides methods for supplementing oral calcium intake in subjects and as well as methods for treating osteoporosis, osteomalacia and related diseases.
    Type: Application
    Filed: August 28, 2015
    Publication date: December 24, 2015
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Amir SAGI, Amir BERMAN, Yosef BEN
  • Orally-administrable compositions comprising stable amorphous calcium carbonate
    Patent number: 9149494
    Abstract: The present invention provides orally-administrable compositions comprising stable amorphous calcium carbonate (ACC). The compositions are preferably prepared as solid dosage forms such as tablets, capsules and powders. The present invention further provides methods for supplementing oral calcium intake in subjects and as well as methods for treating osteoporosis, osteomalacia and related diseases.
    Type: Grant
    Filed: November 24, 2006
    Date of Patent: October 6, 2015
    Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Amir Sagi, Amir Berman, Yosef Ben
  • Insulin-like gene of prawns and uses thereof
    Patent number: 9049850
    Abstract: Nucleic acid molecules encoding an insulin-like factor of the androgenic gland of the freshwater prawn Macrobrachium rosenbergii (M. rosenbergii) are disclosed. Also disclosed are methods of silencing the expression of the insulin-like factor gene in decapod crustaceans order, particularly in M. rosenbergii, useful for producing male monosex populations.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: June 9, 2015
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Amir Sagi, Tomer Ventura
  • AMORPHOUS CALCIUM CARBONATE FOR THE TREATMENT OF CALCIUM MALABSORPTION AND METABOLIC BONE DISORDERS
    Publication number: 20150056306
    Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.
    Type: Application
    Filed: December 13, 2012
    Publication date: February 26, 2015
    Inventors: Amir Sagi, Assaf Shechter, Galit Shaltiel-Gold, Michal Daniely, Oren Meiron
  • Stable amorphous calcium carbonate comprising phosphorylated amino acids
    Patent number: 8802160
    Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated amino acid which stabilizes the amorphous form of said calcium carbonate. The compositions are useful in pharmaceutical and nutraceutical formulations.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: August 12, 2014
    Assignee: Amorphical Ltd.
    Inventors: Shmuel Bentov, Amir Sagi, Amir Berman, Assaf Shechter
  • Composition comprising crustacean gastrolith components and its use
    Patent number: 8728533
    Abstract: Provided is a formulation containing amorphous or microcrystalline calcium carbonate finely interspersed with organic matter in a ratio of 10 parts of the carbonate per 1 to 3 parts of the organic matter, wherein the organic matter consists of chitin and polypeptide. The formulation is efficient in treating various pathological conditions, including proliferative diseases, neurological disorders, and musculoskeletal disorders.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: May 20, 2014
    Assignees: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Yossi Ben, Amir Sagi
  • Insulin-like gene in prawns and uses thereof
    Patent number: 8440878
    Abstract: The present invention relates to a nucleic acid molecule encoding an insulin-like factor of the androgenic gland of the freshwater prawn Macrobrachium rosenbergii (M. rosenbergii). The present invention further relates to methods of silencing the expression of the insulin-like factor gene in decapod crustaceans order, particularly in M. rosenbergii, useful for producing male monosex populations.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: May 14, 2013
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Amir Sagi, Tomer Ventura
  • INSULIN-LIKE GENE IN PRAWNS AND USES THEREOF
    Publication number: 20120073508
    Abstract: The present invention relates to a nucleic acid molecule encoding an insulin-like factor of the androgenic gland of the freshwater prawn Macrobrachium rosenbergii (M. rosenbergii). The present invention further relates to methods of silencing the expression of the insulin-like factor gene in decapod crustaceans order, particularly in M. rosenbergii, useful for producing male monosex populations.
    Type: Application
    Filed: October 19, 2011
    Publication date: March 29, 2012
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Amir Sagi, Tomer Ventura