Abstract: A microwell perfusion plate system includes a plate and at least one well on the plate. Each well includes: a porous membrane; a through-pore microwell membrane above and on the porous membrane, the microwell membrane including a plurality of microwells with a respective microwell configured to hold a 3D cell culture, wherein a respective microwell includes a top opening and a bottom opening; an inlet passageway in fluid communication with each top opening of the plurality of microwells and configured to deliver liquid medium to the plurality of microwells and the 3D cell cultures held therein; an outlet passageway in fluid communication with each bottom opening of the plurality of microwells and configured to receive the liquid medium from the plurality of microwells; and a cell culture well directly above the microwell membrane, wherein the cell culture well defines at least a portion of the inlet passageway.

Abstract: Example collateral optimization systems and methods are described. In one implementation, a collateral optimization system includes a data ingestion engine that receives information associated with a trade and a collateral optimization module configured to optimize collateral associated with the trade. The collateral can be optimized for yield maximization or cost minimization. An asset settlement engine moves assets between multiple counterparties associated with the trade.

Abstract: Example transaction netting systems and methods are described. In one implementation, a financial management system receives information associated with multiple trades and calculates overall obligations and exposures by assets and counterparties. The financial management system further identifies multiple thresholds associated with the multiple trades and selects trades for a particular netting cycle which align with the overall bilateral netted obligations and exposures between counterparties.

Abstract: Example exotic currency settlement systems and methods are described. In one implementation, a financial management system receives information associated with an exotic currency trade and accesses a stochastic model. The financial management system predicts demand for an asset associated with the exotic currency trade at different times in the future based on the stochastic model. Additionally, the financial management system generates a pseudo ledger that suggests a liquidity supply for each entity associated with the exotic currency trade. Information is received regarding contracts entered into by the entities associated with the exotic currency trade, and the pseudo ledger is updated in response to execution of those contracts. The financial management system predicts a best path to perform back-to-back trades associated with the exotic currency trade.

Abstract: Example clearing systems and methods are described. In one implementation, a financial management system calculates an initial margin and a variation margin associated with a financial transaction and provides the initial margin and the variation margin to a workflow. The financial management system pledges securities associated with the initial margin to a central counterparty clearinghouse (CCP). If a futures commission merchant (FCM) is in deficit, the financial management system initiates a debit pull of the variation margin from the FCM. If the FCM has variation margin excess for a particular day, the financial management system initiates a credit push from the CCP to the FCM.

Abstract: Example risk and liquidity management systems and methods are described. In one implementation, a financial management system identifies data associated with a plurality of events in a financial market in substantially real time. The financial management system analyzes the data associated with the plurality of events and, based on the analysis, determines a liquidity demand, a liquidity profile, and a risk profile associated with a particular financial institution. The financial management system then communicates the financial institution's liquidity demand, liquidity profile, and risk profile to the financial institution.