Abstract: The present invention provides an mRNA molecule encoding at least one KRAS variant peptide. Further, the invention provides a pharmaceutical composition and kit comprising the mRNA molecule. The mRNA molecule, pharmaceutical composition and kit are useful for treating cancer.

Abstract: The present disclosure relates to a computer-implemented method for electronic design verification. Embodiments may include receiving an electronic design at a verification environment. Embodiments may also include performing a simulation of a portion of the electronic design in an X-propagation mode. Embodiments may further include determining whether the simulation is entering an element during a time range and determining whether a clock/reset associated with the element has an active X-edge. If the clock/reset has an active X-edge, embodiments may include preventing a recordation of coverage metrics during the time range.

Abstract: The invention relates generally to a system and method for implementing a software release update automation tool without using version numbers. An embodiment of the present invention is directed to an Automation Tool that manages software promotion from different perspectives by using dynamic value injection and automation. This efficiently eliminates or substantially reduces human efforts and manual tasks on the complicated process of version management. In addition, the Automation Tool of an embodiment of the present invention may further take current version snapshots, manage change logs for audit, perform version validation for match and unmatched build post promotion, and provide email or other communication notification and/or alerts.

Abstract: Images are tagged with values in an image data hierarchy that is most subjective at its top level and least subjective at its bottom level, such as a hierarchy including style, type, and features for clothing. A user preference hierarchy is determined from user response to images that are tagged. Tagged images may be generated by processing them with machine learning models trained to determine values for images. Product records including images and other data are analyzed to generate attribute vectors that are encoded to generate product vectors. Products are clustered according to their product vectors. Images of products within a cluster are clustered according to composition and groups of images are selected from image clusters for soliciting feedback regarding user preference for products of a cluster. Feedback is used to train a user preference model to estimate user affinity for a product having a given product vector.

Abstract: Example order management systems and methods are described. In one implementation, a catalog ingestion system receives data associated with multiple products offered by multiple brands. A commerce management system receives a customer order from a customer. The customer order includes at least a portion of the multiple products offered by the multiple brands. The commerce management system splits the customer order into multiple brand orders such that each brand order is associated with products in the customer order from a particular brand. An integration platform fulfills the brand orders by submitting the brand orders to the associated brands.

Abstract: A promotion program analytical system and method is disclosed. The promotion program analytical system and method selects a promotion program to offer to a consumer. Selection of the promotion program to present to the consumer includes determining a probability that the consumer will accept the promotion program. The probability of acceptance may be determined based on past performance data of similar promotion programs, and also past performance data on the promotion program itself when it is available.

Abstract: A log file including prediction information specifying a local advertisement content allocation amount and a general advertisement content allocation amount over a predetermined duration of time is received. A chronological schedule designating media content spots and advertising spots for the predetermined duration of time is also received. It is determined that a sold amount of local advertisement content during a particular time period, which is less than the predetermined duration of time, is insufficient to fill the local allocation during that time period, A portion of the local allocation is reallocated to the general allocation for the particular time period, while leaving the local and general allocation amounts unchanged over the predetermined duration of time. A program log is generated in accordance with the prediction information and the reallocating.

Abstract: An automated planning system obtains media advertising order specifications associated with media placement orders, wherein the media advertising order specifications include flexibility attributes associated with media items referenced in the media placement orders. The planning system generates an orders table including order information associated with individual orders, an inventory table including inventory information associated with individual inventory items, and an association table including association scores indicating levels of association between the individual inventory items and the individual orders, wherein the association scores are based on the flexibility attributes. The media placement orders are booked into a plan lineup based, at least in part, on the association scores.

Abstract: A promotion program analytical system and method is disclosed. The promotion program analytical system and method selects a promotion program to offer to a consumer. Selection of the promotion program to present to the consumer includes determining a probability that the consumer will accept the promotion program. The probability of acceptance may be determined based on past performance data of similar promotion programs, and also past performance data on the promotion program itself when it is available.

Abstract: Electronic correspondence that includes one or more promotions may be generated for presenting to a consumer. In order to determine whether to present the electronic correspondence to the consumer, the promotions included in the electronic correspondences may be analyzed in terms of a probability the consumer will accept the promotions, a relevance level between the promotions and attributes of the consumer, a relevance level between the promotions and the consumer, a relevance level between the promotions and a set of goals or rules, among other similar terms. After the analysis, a determination may be made whether to send the electronic correspondence to the consumer. Similarly, the analysis may compare multiple electronic correspondences, and determine, based on the comparison, which of the multiple electronic correspondences to send to the consumer.

Abstract: Total advertising inventory of a broadcast station can be dynamically allocated between local, or station-sold, inventory and general, or network, inventory. The portion of total inventory allocated to local inventory or network inventory can be adjusted based on feedback from an advertising service, and a broadcast log can be generated based on the adjusted allocation. The broadcast log can be delivered to a media automation system associated with a media station which plays out local inventory in accordance with the broadcast log. When the broadcast log indicates that general/network inventory is to be broadcast, the media automation system stops playing-out local inventory, and allows the advertisement system to broadcast network inventory for a period of time indicated by the broadcast log. Broadcast of local inventory can be resumed early, before the time period indicated in the broadcast log has expired.

Abstract: A sales enhancement system and method is disclosed. The sales enhancement system is configured to use one or more deal program collections, which are groupings or compilations of deal programs. The sales enhancement system manages deal programs in the deal program collections at various stages of use including: associating a deal program with multiple deal program collections; determining the number of deals to assign to the different deal programs; using triggers to select which deal program collections to access; transmitting an offer for a deal; and processing acceptances of the offers.

Abstract: A planning system obtains an order attribute table associating media advertising orders with flexibility attribute values that indicate scheduling flexibility, and generates an inventory table having cells representing station-daypart combinations. The cells of the inventory table are assigned flexibility attribute values corresponding to the flexibility attribute values of orders booked into corresponding station-daypart combinations. The planning system makes a comparison between a first flexibility attribute associated with an un-booked order and a second flexibility attribute associated with a booked order already booked in a particular station-daypart combination, where the comparison shows that the un-booked order has less scheduling flexibility than the booked order. In response to the comparison, an association between the booked order and the particular station-daypart combination is replaced with an association between the un-booked order and the particular station-daypart combination.

Abstract: A deal program life cycle system and method is disclosed. The deal program life cycle may oversee the issuance of deals from a deal program to consumers over the life cycle of the deal program. One or more aspects of the deal program may change during different periods of the life cycle of the deal program. For example, the deal program may include deal features, a number of units for deals, and relevance features for the deal program. The deal features, number of units of deals, and/or relevance features for the deal program may change during the different periods of the life cycle.

Abstract: In a promotion offering system, a promotion offering may be presented to a consumer on more than one occasion. The previous presentation of the promotion to the consumer may affect a subsequent presentation of the same promotion to the same consumer. The present invention provides an apparatus and method for analyzing the effect a previous presentation of a promotion may have on a consumer when the promotion is presented to the consumer at a subsequent time.

Abstract: A promotion system for determining a deficiency in promotion data and correcting for the deficiency is disclosed. Issuing offers from a promotion program results in promotion data being generated. The promotion data may be analyzed to determine an acceptance rate of the offers. The promotion system may compare whether the acceptance rate is above a predetermined threshold, but has a confidence level that is less than a confidence rate threshold. In that event, the promotion system may issue additional offers in order to increase the confidence level associated with the acceptance rate by a predetermined amount.

Abstract: Systems and methods are presented for managing the cadence (e.g., frequency or rate) that electronic promotion correspondence is sent to a consumer. A system may access a target cadence indicator associated with a consumer that indicates of a target rate for sending electronic promotion correspondence to the consumer. The system may also determine an actual cadence indicator for the consumer over a predetermined period of time and analyze a potential electronic promotion correspondence for sending to the consumer. The system determines whether to send the electronic correspondence to the consumer based on the target cadence indicator, the actual cadence indicator, and the analysis of the electronic promotion correspondence.

Abstract: The invention relates generally to a system and method for implementing a software release update automation tool without using version numbers. An embodiment of the present invention is directed to an Automation Tool that manages software promotion from different perspectives by using dynamic value injection and automation. This efficiently eliminates or substantially reduces human efforts and manual tasks on the complicated process of version management. In addition, the Automation Tool of an embodiment of the present invention may further take current version snapshots, manage change logs for audit, perform version validation for match and unmatched build post promotion, and provide email or other communication notification and/or alerts.

Abstract: A system and method is provided for determining a portfolio of promotions from across a diverse mix of promotion categories. The diverse promotion portfolio may represent an inventory of promotions that are available for presenting to a consumer in a particular market. Also, a system and method is provided for determining a diverse group of promotions for presenting to a consumer. The diverse group of promotions may be determined based on whether a same or similar promotion was previously presented to the consumer.

Abstract: In a promotion offering system, a promotion offering may be presented to a consumer on more than one occasion. The previous presentation of the promotion to the consumer may affect a subsequent presentation of the same promotion to the same consumer. The present invention provides an apparatus and method for analyzing the effect a previous presentation of a promotion may have on a consumer when the promotion is presented to the consumer at a subsequent time.