Patents by Inventor Amit AWASTHI

Amit AWASTHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240424087
    Abstract: The present invention is drawn to a next generation nano vaccine platform by using structure-based design to utilize the conserved or less variable or highly immunogenic domains or epitopes and displaying it in a nano cage and produces it in as nanoparticle protein in prokaryotic expression system. The present invention is illustrated in detail by a vaccine design and construct for SARS CoV-2, SARS-CoV-2 variants, betacorona viruses, Monkey pox virus and Dengue virus.
    Type: Application
    Filed: October 11, 2022
    Publication date: December 26, 2024
    Inventors: Sweety Samal, Shubbir Ahmed, Amit Awasthi, Ritika Khatri
  • Publication number: 20230321188
    Abstract: The present invention discloses a novel engineered peptides P3T, P7T, P8T, P9T, P13T and P8_d1 of Seq ID No. 1 to combinations comprising one or more said peptides and compositions comprising one or more said peptides with pharmaceutically acceptable carriers and excipients and their use. The peptides and composition comprising said peptides induce autophagy by binding the protein GAPR-1 (?ve regulator of autophagy). Endogenously, GAPR-1 acts by tethering critical autophagy protein Beclin-1 (+ve regulator of autophagy) at the golgi and arrest autophagy. The peptide reported here binds GAPR-1 to free Beclin-1 and subsequently induce autophagy. The peptide can be used to induce or enhance autophagy and finds therapeutic application in a broad spectrum of disease pathologies that benefit from augmented autophagy, including obesity, diabetes, NASH, cancer, cardiomyopathy, neurodegenerative diseases, IBD and pathogenic infections.
    Type: Application
    Filed: August 19, 2021
    Publication date: October 12, 2023
    Inventors: Shailendra ASTHANA, Charu SURI, Manjula KALIA, Amit AWASTHI, Ajit CHANDE, Ambadas RODE, Surendra kumar PRAJAPAT, Srikanth SADHU, Rajdeep DALAL, Vipin BHARDWAJ, Divya OJHA