Abstract: Systems and methods include, responsive to security research identifying a zero-day Common Vulnerabilities and Exposure (CVE), receiving the associated signatures of the zero-day CVE; responsive to determining a user can access an application via a cloud-based system, wherein the application is in one of a public cloud, a private cloud, and an enterprise network, and wherein the user is remote over the Internet, obtaining an inspection profile for the user with the inspection profile including a plurality of rules; performing inspection of transactions after the access using the plurality of rules including a rule for identifying the zero-day CVE; and responsive to results of any of the plurality of rules, one or more of monitoring, allowing, blocking, and redirecting the access, via the cloud-based system.