Abstract: Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.

Abstract: Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.

Abstract: As demonstrated herein, soluble human FcRn binds to AFP with affinities greater than observed with albumin, and is able to interfere with FcRn-mediated protection of and functional associations with IgG. Accordingly, provided herein, in some aspects, are compositions and methods to inhibit FcRn and AFP interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate FcRn and AFP interactions in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels increasing with immunosuppression.

Abstract: An apparatus and method for evaporative containment of liquid or solid wastes includes an evaporative membrane for receiving the solid or liquid waste and at least one flap including a wicking layer, an odor-neutralizing layer, or both, and a skeletal frame. An apparatus and method for moisture removal from media includes a hydrophilic evaporative layer and a wicking layer, the hydrophilic evaporative layer being non-porous or nano-porous and allowing selective passage of vapor water molecules while preventing passage of suspended or dissolved solids, ions, salt, or pollutants, the wicking layer absorbing and spreading bulk moisture across a surface area. An apparatus and method for collecting liquid or solid wastes includes liquid and solid waste capture containers capable of volume reduction of captured waste and generating a liquid or gas effluent with fewer impurities than the captured waste.

Abstract: A system for providing call center agent desktops is provided comprising a computer and an application executing on the computer. The system receives a request from a client device for a desktop image and accesses a stored desktop image for the client device. The system also enables links in the stored image to at least two ACD systems and provides access to the image to the client device. The client device is used by a call center agent responding to incoming calls via desktop ACD access provided by the activated links. The at least two ACD systems are provided by unrelated vendors. Access to the at least two ACD systems is provided by at least one adapter executing on the computer, the at least one adapter created from at least two application programming interfaces (API) furnished by providers of the at least two ACD systems.

Abstract: Provided herein are recombinant antibodies and antigen-binding fragments thereof useful for binding to and inhibiting carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Also provided are methods of using the disclosed CEACAM1 antibodies and antigen-binding fragments thereof for reducing T-cell tolerance and for the treatment of cancer.

Abstract: The technology described herein is directed to immunotherapy agents for autoimmune disease, cancer, or allergy. In some embodiments, the immunotherapy agent comprises a bispecific antibody construct that specifically binds FcRn and a Type I or Type II Fc? T receptor. In some embodiments the bispecific antibody construct is a DvD-Ig construct. Also described herein are methods for treating autoimmune disease, cancer, or allergy, comprising administering an effective amount of a bispecific antibody construct to patient in need thereof.

Abstract: As demonstrated herein, soluble human FcRn binds to AFP with affinities greater than observed with albumin, and is able to interfere with FcRn-mediated protection of and functional associations with IgG. Accordingly, provided herein, in some aspects, are compositions and methods to inhibit FcRn and AFP interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate FcRn and AFP interactions in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels increasing with immunosuppression.

Abstract: As demonstrated herein, soluble human FcRn binds to AFP with affinities greater than observed with albumin, and is able to interfere with FcRn-mediated protection of and functional associations with IgG. Accordingly, provided herein, in some aspects, are compositions and methods to inhibit FcRn and AFP interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate FcRn and AFP interactions in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels increasing with immunosuppression.

Abstract: Described herein are novel compositions, targeted therapeutic methods, and assays for neutralizing and/or inhibiting the activity of “oxazole-containing (OxC) compounds,” to prevent or delay the onset of epithelial barrier dysfunction and chronic inflammation associated with various disorders, such as colitis.

Abstract: Provided herein, in some aspects, are compositions and methods to inhibit AFP interactions with ?2M and/or Class I-related molecule interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate AFP interactions with ?2M and/or Class I-related molecule in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels is desired to increase immunosuppression or enhance organ regeneration.

Abstract: Described herein are compositions and methods for modulating immune response, which can be upregulated or down regulated by enhancement or inhibition of interactions between CEACAM family members and TIM family members.

Abstract: Described herein are compositions and methods for modulating immune response, which can be upregulated or down regulated by enhancement or inhibition of interactions between CEACAM family members and TIM family members.

Abstract: As demonstrated herein, soluble human FcRn binds to AFP with affinities greater than observed with albumin, and is able to interfere with FcRn-mediated protection of and functional associations with IgG. Accordingly, provided herein, in some aspects, are compositions and methods to inhibit FcRn and AFP interactions in diseases or disorders where elevated AFP levels are associated with immunosuppression. Also provided herein, in some aspects, are compositions and methods to enhance or potentiate FcRn and AFP interactions in diseases or disorders with decreased AFP levels or diseases or disorders where increasing AFP levels increasing with immunosuppression.

Abstract: A technique to allow independent loads to be satisfied during high-latency instruction processing. Embodiments of the invention relate to a technique in which a storage structure is used to hold store operations in program order while independent load instructions are satisfied during a time in which a high-latency instruction is being processed. After the high-latency instruction is processed, the store operations can be restored in program order without searching the storage structure.

Abstract: A system and method of security authentication and key management scheme in a multi-hop wireless network is provided herein with a hop-by-hop security model. The scheme adapts the 802.11r key hierarchy into the meshed AP network. In this approach, a top key holder (R0KH) derives and holds the top Pairwise Master Key (PMK—0) for each supplicant wireless device after the authentication process. All authenticator AP take the level one key holder (R1KH) role and receive the next level Pairwise Master Key (PMK—1) from R0KH. The link level data protection key is derived from PMK—1 via the 802.11i 4-way handshaking.

Abstract: A system and method of security authentication and key management scheme in a multi-hop wireless network is provided herein with a hop-by-hop security model. The scheme adapts the 802.11r key hierarchy into the meshed AP network. In this approach, a top key holder (R0KH) derives and holds the top Pairwise Master Key (PMK_0) for each supplicant wireless device after the authentication process. All authenticator AP take the level one key holder (R1KH) role and receive the next level Pairwise Master Key (PMK_1) from R0KH. The link level data protection key is derived from PMK_1 via the 802.11i 4-way handshaking.

Abstract: A technique to allow independent loads to be satisfied during high-latency instruction processing. Embodiments of the invention relate to a technique in which a storage structure is used to hold store operations in program order while independent load instructions are satisfied during a time in which a high-latency instruction is being processed. After the high-latency instruction is processed, the store operations can be restored in program order without searching the storage structure.

Abstract: A system and method of security authentication and key management scheme in a multi-hop wireless network is provided herein with a hop-by-hop security model. The scheme adapts the 802.11r key hierarchy into the meshed AP network. In this approach, a top key holder (R0KH) derives and holds the top Pairwise Master Key (PMK—0) for each supplicant wireless device after the authentication process. All authenticator AP take the level one key holder (R1KH) role and receive the next level Pairwise Master Key (PMK—1) from R0KH. The link level data protection key is derived from PMK—1 via the 802.11i 4-way handshaking.

Abstract: A system and method of security authentication and key management scheme in a multi-hop wireless network is provided herein with a hop-by-hop security model. The scheme adapts the 802.11r key hierarchy into the meshed AP network. In this approach, a top key holder (R0KH) derives and holds the top Pairwise Master Key (PMK_0) for each supplicant wireless device after the authentication process. All authenticator AP take the level one key holder (R1KH) role and receive the next level Pairwise Master Key (PMK_1) from R0KH. The link level data protection key is derived from PMK_1 via the 802.11i 4-way handshaking.