Patents by Inventor Amit N. Patel

Amit N. Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190040361
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment, the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Application
    Filed: March 2, 2018
    Publication date: February 7, 2019
    Inventors: Francisco Javier Silva, Mark Weinreb, Amit N. Patel, David A. Bull
  • Publication number: 20180360992
    Abstract: The present invention provides compositions and methods useful for treating disorders amenable to therapy via introduction of multigenic expression vectors. More particularly, the invention provides vectors and polynucleotides encoding polypeptides for treatment of cardiac disorders wherein said polypeptides may comprise a cytokine, a chemokine, and/or an angiogenic polypeptide, or functional derivatives thereof. Also provided, as compositions of the invention, are linkers useful for connecting and expressing functional (biologically active) polypeptides from single, multigenic-expression constructs.
    Type: Application
    Filed: May 11, 2018
    Publication date: December 20, 2018
    Inventors: Dimki S. Patel, Amit N. Patel
  • Publication number: 20170196951
    Abstract: Compositions of matter, of production, and treatment modalities are disclosed for the prevention and/or therapeutic reduction of tumors through induction of immunity against tumor associated fibroblasts and components of tumor microenvironment. In one embodiment of the invention, placentally derived fibroblast cells are cultured under conditions replicating tumor microenvironment. Expression of CD248 on said cultured fibroblasts is used as a marker of effective manipulation. Cells expressing CD248 are utilized a immunogens for stimulation of immunity towards cancer associated fibroblastic cells.
    Type: Application
    Filed: August 8, 2016
    Publication date: July 13, 2017
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Amit N. Patel
  • Publication number: 20170151281
    Abstract: The current invention provides monocytic cells transfected with chimeric antigen receptor (CAR) to selectively home to tumors and upon homing differentiate into dendritic cells capable of activating immunity which is inhibitory to said tumor. In one embodiment of the invention, monocytic cells are transfected with a construct encoding an antigen binding domain, a transcellular or structural domain, and an intracellular signaling domain. In one specific aspect of the invention, the antigen binding domain interacts with sufficient affinity to a tumor antigen, capable of triggering said intracellular domain to induce an activation signal to induce monocyte differentiation into DC.
    Type: Application
    Filed: February 19, 2016
    Publication date: June 1, 2017
    Applicant: Batu Biologics, Inc.
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Julia S. Szymanski, Santosh Kesari, Amit N. Patel, Boris Minev
  • Publication number: 20170000894
    Abstract: Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety. Also described herein are methods for treating disease states, such as acute myocardial ischemia or infarction, with said compositions, in a subject.
    Type: Application
    Filed: January 20, 2015
    Publication date: January 5, 2017
    Inventors: Young-Wook WON, David A. BULL, Amit N. PATEL
  • Publication number: 20160213764
    Abstract: Disclosed are composite cancer vaccines, in one embodiment generated through 3-dimensional bioprinting or through inoculation of roller cultures. The utilization of decellularized biological matrices such as placental tissue or subintestinal submucosal tissue is disclosed as a substrate for 3-dimensional tissue culture. In one embodiment tumor cells are assembled with monocytes and/or mesenchymal stem cells to represent in vivo existing tumors.
    Type: Application
    Filed: January 22, 2016
    Publication date: July 28, 2016
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Santosh Kesari, Amit N. Patel
  • Publication number: 20160206717
    Abstract: Disclosed are compositions of matter, methods, and protocols useful for treatment of cancer through induction of anti-angiogenic immune responses. The invention provides means of differentiating tumor cells directly into endothelial or endothelial-like cells and utilizing said cells as immunogens for the purpose of inducing immunity against blood vessels feeding tumors. In one embodiment glioma cells are cultured under hypoxic conditions in the presence of endothelial-differentiating factors. In another embodiment, PECAM-1 positive cells are derived from a tumor mass or cell line and utilized as an antigenic source to induce immunity towards tumor derived endothelial cells, endothelial-like cells, and tumor vascular channels.
    Type: Application
    Filed: January 19, 2016
    Publication date: July 21, 2016
    Inventors: Samuel C. Wagner, Thomas E. Ichim, Santosh Kesari, Amit N. Patel
  • Patent number: 9133438
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: September 15, 2015
    Assignee: BIORESTORATIVE THERAPIES, INC.
    Inventors: Francisco Silva, Mark Weinreb, Amit N. Patel, David A. Bull
  • Publication number: 20140370591
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Application
    Filed: June 28, 2012
    Publication date: December 18, 2014
    Applicant: BioRestorative Ttherapies, Inc.
    Inventors: Francisco Javier Silia, Mark Weinreb, Amit N. Patel, David A. Bull
  • Publication number: 20140038177
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Application
    Filed: July 1, 2013
    Publication date: February 6, 2014
    Inventors: Francisco Javier Silva, Mark Weinreb, Amit N. Patel, David A. Bull
  • Publication number: 20140023622
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 23, 2014
    Inventors: Francisco Javier Silva, Mark Weinreb, Amit N. Patel, David A. Bull
  • Publication number: 20140017789
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 16, 2014
    Inventors: Francisco Javier Silva, Mark Weinreb, Amit N. Patel, David A. Bull
  • Publication number: 20130071360
    Abstract: Methods of developing and using cell lines, such as stem cell lines, for therapeutic or cosmetic use. In one embodiment the cell lines are used to treat a wide range of degenerative and metabolic disorders including, but not limited to, obesity, diabetes, hypertension, and cardiac deficiency. Also described are methods of using such cell lines to screen for compounds that play a role in regulating a variety of processes.
    Type: Application
    Filed: June 28, 2012
    Publication date: March 21, 2013
    Applicant: BIORESTORATIVE THERAPIES, INC.
    Inventors: Francisco Silva, Mark Weinreb, Amit N. Patel, David A. Bull