Patents by Inventor Amit Nargotra

Amit Nargotra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof
    Patent number: 10017511
    Abstract: The present invention relates to Pyrazolopyrimidinone compounds as PDE5 inhibitors with better IC50 value, good in vivo efficacy and PK profile and a process for the preparation thereof. The present invention covers the pyrazolo pyrimidinone based compounds that have been designed, synthesized and screened for PDE5 inhibitory activity and its PDE5 inhibitory potential is provided in this invention. These designer compounds have shown nanomolar potency when screened for PDE5 inhibitory activity and also shown better in vivo efficacy. These compounds can be used in the treatment of male erectile dysfunction or in the treatment of impotence.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: July 10, 2018
    Assignee: Council of Scientific & Industrial Research
    Inventors: Sanghapal Damodhar Sawant, Lakshma Reddy Ginnereddy, Srinivas Mahesuni, Sajad Hussain Syed, Mohd Ishaq Dar, Amit Nargotra, Priya Mahajan, Ram Asrey Vishwakarma
  • 1,3,5 -triazine based PI3K inhibitors as anticancer agents and a process for the preparation thereof
    Patent number: 9951040
    Abstract: The present invention describes heterocyclic compounds of general Formula 1 and their method of preparation thereof. The present invention describes general Formula 1 which inhibits phosphoinositide 3-kinase (PI3K) and can be used as the anticancer agents.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: April 24, 2018
    Assignee: Council of Scientific and Industrial Research
    Inventors: Thanusha Thatikonda, Suresh Kumar, Umed Singh, Priya Mahajan, Girish Mahajan, Amit Nargotra, Fayaz Malik, Dilip Manikrao Mondhe, Ram Asrey Vishwakarma, Parvinder Pal Singh
  • 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles and a process for the preparation thereof
    Patent number: 9845330
    Abstract: The present invention relates to newer generation of triazoles, tetrazoles, isoxazoles, urea and sulphonamide functionalities containing 6-nitro-2,3-dihydronitroimidazooxazoles agents of formula 1, their method of preparation, and their use as drugs for treating Mycobacterium tuberculosis, MDR-TB and XDR-TB either alone or in combination with other anti-tubercular agents. In the present invention, new generation 6-nitro-2,3-dihydronitroimidazooxazoles agents also show acceptable pharmacokinetic properties and synergistic or additive effects with known anti-tubercular drugs.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: December 19, 2017
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Parvinder Pal Singh, Gurunadham Munagala, Reddy Yempalla Kushalava, Inshad Ali Khan, Nitin Pal Kalia, Vikrant Singh Rajput, Amit Nargotra, Sanghapal Damodhar Sawant, Ram Asray Vishwakarma
  • NOVEL 1,3,5 -TRIAZINE BASED PI3K INHIBITORS AS ANTICANCER AGENTS AND A PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20170342049
    Abstract: The present invention describes heterocyclic compounds of general Formula 1 and their method of preparation thereof. The present invention describes general Formula 1 which inhibits phosphoinositide 3-kinase (PI3K) and can be used as the anticancer agents.
    Type: Application
    Filed: November 17, 2015
    Publication date: November 30, 2017
    Inventors: Thanusha Thatikonda, Suresh Kumar, Umed Singh, Priya Mahajan, Girish Mahajan, Amit Nargotra, Fayaz Malik, Dilip Manikrao Mondhe, Ram Asrey Vishwakarma, Parvinder Pal Singh
  • Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof
    Publication number: 20170066771
    Abstract: The present invention relates to Pyrazolopyrimidinone compounds as PDE5 inhibitors with better IC50 value, good in vivo efficacy and PK profile and a process for the preparation thereof. The present invention covers the pyrazolo pyrimidinone based compounds that have been designed, synthesized and screened for PDE5 inhibitory activity and its PDE5 inhibitory potential is provided in this invention. These designer compounds have shown nanomolar potency when screened for PDE5 inhibitory activity and also shown better in vivo efficacy. These compounds can be used in the treatment of male erectile dysfunction or in the treatment of impotence.
    Type: Application
    Filed: October 20, 2014
    Publication date: March 9, 2017
    Inventors: Sanghapal Damodhar SAWANT, Lakshma Reddy GINNEREDDY, Srinivas MAHESUNI, Sajad Hussain SYED, Mohd Ishaq DAR, Amit NARGOTRA, Priya MAHAJAN, Ram Asrey VISHWAKARMA
  • 6-NITRO-2,3-DIHYDROIMIDAZO[2,1-b]OXAZOLES AND A PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20160244462
    Abstract: The present invention relates to newer generation of triazoles, tetrazoles, isoxazoles, urea and sulphonamide functionalities containing 6-nitro-2, 3-dihydronitroimidazooxazoles agents of formula 1, their method of preparation, and their use as drugs for treating Mycobacterium tuberculosis, MDR-TB and XDR-TB either alone or in combination with other anti-tubercular agents. In the present invention, new generation 6-nitro-2, 3-dihydronitroimidazooxazoles agents also show acceptable pharmacokinetic properties and synergistic or additive effects with known anti-tubercular drugs.
    Type: Application
    Filed: March 31, 2014
    Publication date: August 25, 2016
    Applicant: Council of Scientific & Industrial Research
    Inventors: Parvinder Pal SINGH, Gurunadham MUNAGALA, Reddy Yempalla KUSHALAVA, Inshad Ali KHAN, Nitin Pal KALIA, Vikrant Singh RAJPUT, Amit NARGOTRA, Sanghapal Damodhar SAWANT, Ram Asray VISHWAKARMA
  • Boronic acid bearing liphagane compounds as inhibitors of P13K-? and/or ?
    Patent number: 9206201
    Abstract: Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: December 8, 2015
    Assignee: Counsel of Scientific & Industrial Research
    Inventors: Ram Asrey Vishwakarma, Sanghapal Damodhar Sawant, Parvinder Pal Singh, Abid Hamid Dar, Parduman Raj Sharma, Ajit Kumar Saxena, Amit Nargotra, Anjaneya Aravind Kumar Kolluru, Ramesh Mudududdla, Asif Khurshid Qazi, Aashiq Hussain, Nayan Chanauria
  • BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF P13K- a AND/OR B
    Publication number: 20150051173
    Abstract: Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 19, 2015
    Inventors: Ram Asrey Vishwakarma, Sanghapal Damodhar Sawant, Parvinder Pal Singh, Abid Hamid Dar, Parduman Raj Sharma, Ajit Kumar Saxena, Amit Nargotra, Anjaneya Aravind Kumar Kolluru, Ramesh Mudududdla, Asif Khurshid Qazi, Aashiq Hussain, Nayan Chanauria