Patents by Inventor Amit S. Kalgutkar

Amit S. Kalgutkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
    Patent number: 6762182
    Abstract: A method of altering specificity of cyclooxygenase-inhibiting compounds that have a COOH moiety by changing the various COOH containing compounds, such as indomethacin, into ester derivatives or into secondary amide derivatives.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: July 13, 2004
    Assignee: Vanderbilt University
    Inventors: Amit S. Kalgutkar, Lawrence J. Marnett
  • Amide derivatives for antiangiogenic and/or antitumorigenic use
    Patent number: 6399647
    Abstract: A method of treating animals having cancer by administration of secondary amide derivatives of various COOH-containing drugs, such as COOH-containing NSAIDs, for instance, indomethacin.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: June 4, 2002
    Assignee: Vanderbilt University
    Inventors: Amit S. Kalgutkar, Lawrence J. Marnett
  • Amide derivatives for antiangiogenic and/or antitumorigenic use
    Publication number: 20010034361
    Abstract: A method of treating animals having cancer by administration of secondary amide derivatives of various COOH-containing drugs, such as COOH-containing NSAIDs, for instance, indomethacin.
    Type: Application
    Filed: March 27, 2001
    Publication date: October 25, 2001
    Inventors: Amit S. Kalgutkar, Lawrence J. Marnett
  • Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
    Patent number: 6306890
    Abstract: A compound of the formula where: n, and X are as defined in the specification, and the compound possesses selectivity for inhibition of cyclooxygenase-2.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: October 23, 2001
    Assignee: Vanderbilt University
    Inventors: Amit S. Kalgutkar, Lawrence J. Marnett
  • Selective inhibitors of prostaglandin endoperoxide synthase-2
    Patent number: 6284918
    Abstract: The present invention provides a compound of the formula wherein when X is S; R is selected from the group consisting of CH3, CH2CH3, CH2Ph, (CH2)2Ph, (CH2)2CH3, (CH2)3CH3, (CH2)4CH3, CH2)5CH3, (CH2)6CH3, (CH2)2O(CH2)3CH3, CH2HC═CH(CH2)3CH3, CH2C≡C(CH2)3CH3, CH2C≡C(CH2)2CH3, CH2C≡CCH2CH3, CH2C≡CCH3, CH2C≡CH, CH2C≡C(CH2)4CH3, CH2C≡C(CH2)5CH3, CH2C≡C(CH2)6CH3, (CH2)2C≡C(CH2)2CH3, CH(Ch3)C≡C(CH2)3CH3, (CH2)6I, (CH2)6Br, (CH2)5Br, (CH2)5COOH and (CH2)5OCOCH3, and R′ is selected from the group consisting of CH3, CF3, CH2Cl, CH2Br, CH2CH3, NH2, and OSO2CH3; wherein when R is CH3, R′ can not be CH3 or CH2Cl; wherein when R is CH2CH3, R′ can not be CH3; wherein when X is Se, R is (CH2)6CH3, and R′ is CH3 or a pharmaceutically acceptable salt or hydrate thereof; and wherein when X is O, R is CH2C≡C(CH2)3CH3, and R′ is CH3 or a pharmaceutically acceptable salt or hydrate thereof.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: September 4, 2001
    Assignee: Vanderbilt University
    Inventors: Lawrence J. Marnett, Amit S. Kalgutkar
  • Amide derivatives for antiangiogenic and/or antitumorigenic use
    Patent number: 6207700
    Abstract: A method of treating animals having cancer by administration of secondary amide derivatives of various COOH-containing drugs, such as COOH-containing NSAIDs, for instance, indomethacin.
    Type: Grant
    Filed: January 7, 1999
    Date of Patent: March 27, 2001
    Assignee: Vanderbilt University
    Inventors: Amit S. Kalgutkar, Lawrence J. Marnett
  • Selective inhibitors of prostaglandin endoperoxide synthase-2
    Patent number: 5973191
    Abstract: The present invention provides a compound of the formula ##STR1## wherein R is selected from the group consisting of CH.sub.3, CH.sub.2 CH.sub.3, (CH.sub.2).sub.2 CH.sub.3, (CH.sub.2).sub.3 CH.sub.3, (CH.sub.2).sub.4 CH.sub.3, (CH.sub.2).sub.5 CH.sub.3, (CH.sub.2).sub.6 CH.sub.3, (CH.sub.2).sub.2 O(CH.sub.2).sub.3 CH.sub.3, CH.sub.2 HC.dbd.CH(CH.sub.2).sub.3 CH.sub.3, CH.sub.2 C.tbd.C(CH.sub.2).sub.3 CH.sub.3, CH.sub.2 C.tbd.C(CH.sub.2).sub.2 CH.sub.3, CH.sub.2 C.tbd.CCH.sub.2 CH.sub.3, CH.sub.2 C.tbd.CCH.sub.3 and CH.sub.2 C.tbd.CH; and R' is selected from the group consisting of CH.sub.3, CF.sub.3, CH.sub.2 Cl and CH.sub.2 Br or a pharmaceutically acceptable salt or hydrate thereof. Also provided is a method of inhibiting the synthesis of prostaglandin endoperoxide syntase-2 (PGHS-2) in a mammal.
    Type: Grant
    Filed: December 30, 1996
    Date of Patent: October 26, 1999
    Assignee: Vanderbilt University
    Inventors: Lawrence J. Marnett, Amit S. Kalgutkar
  • Compounds and compositions for inhibition of cyclooxygenase activity
    Patent number: 5475021
    Abstract: The present invention includes N-substituted maleimides (1(H)-Pyrrole-2,5-dione (Maleimide) analogs and succinimides which act as potent nonsteroidal anti-inflammatory drugs and are capable of dual inactivation or selective inactivation of the cyclooxygenase and the peroxidase activities of prostaglandin endoperoxide synthase (PGHS).
    Type: Grant
    Filed: December 3, 1993
    Date of Patent: December 12, 1995
    Assignee: Vanderbilt University
    Inventors: Lawrence J. Marnett, Amit S. Kalgutkar