Patents by Inventor Amit Sawant
Amit Sawant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230181930Abstract: A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.Type: ApplicationFiled: February 7, 2023Publication date: June 15, 2023Inventors: Amit Sawant, Robert Timmerman, Yulong Yan, Henky Wibowo, Esther Vicente, Arezoo Modiri
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Patent number: 11633623Abstract: A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.Type: GrantFiled: April 20, 2020Date of Patent: April 25, 2023Assignees: University of Maryland, Baltimore, The Board of Regents of the University of Texas System, BroncusInventors: Amit Sawant, Robert Timmerman, Yulong Yan, Henky Wibowo, Esther Vicente, Arezoo Modiri
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Patent number: 10898157Abstract: A lung motion phantom device and method of operation. The device has a body having an outer shell and a lung insert, a first actuator connected to a first drive linkage for driving a first displacement of an internal volume of the lung insert and an outer surface of the outer shell in a first direction, a second actuator connected to a second drive linkage for driving a second displacement of the internal volume of the lung insert and the outer surface of the outer shell in a second direction different than the first direction, and a controller programmed to control the first and second actuators such that the first and second displacements simulate movement of an external surface and an interior of a thoracic region of a patient.Type: GrantFiled: February 6, 2019Date of Patent: January 26, 2021Assignee: University of Maryland, BaltimoreInventors: Amit Sawant, Maida Ranjbar, Pouya Sabouri, Carlo Repetto
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Publication number: 20200330795Abstract: A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.Type: ApplicationFiled: April 20, 2020Publication date: October 22, 2020Inventors: Amit Sawant, Robert Timmerman, Yulong Yan, Henky Wibowo, Esther Vicente, Arezoo Modiri
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Publication number: 20190239846Abstract: A lung motion phantom device and method of operation. The device has a body having an outer shell and a lung insert, a first actuator connected to a first drive linkage for driving a first displacement of an internal volume of the lung insert and an outer surface of the outer shell in a first direction, a second actuator connected to a second drive linkage for driving a second displacement of the internal volume of the lung insert and the outer surface of the outer shell in a second direction different than the first direction, and a controller programmed to control the first and second actuators such that the first and second displacements simulate movement of an external surface and an interior of a thoracic region of a patient.Type: ApplicationFiled: February 6, 2019Publication date: August 8, 2019Inventors: Amit Sawant, Maida Ranjbar, Pouya Sabouri, Carlo Repetto
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Patent number: 8971489Abstract: A method of multileaf collimator (MLC) leaf positioning in tracking-based adaptive radiotherapy is provided. The method includes determining a radiotherapy beam pattern by transforming a treatment beam plan into radiotherapy beam coordinates, determining a dose discrepancy between the radiotherapy beam pattern and a deliverable MLC aperture, where the dose discrepancy includes a sum of an overdose cost and an underdose cost to a treatment volume, and minimizing the dose discrepancy, where the dose discrepancy minimization provides a determined deliverable MLC aperture for the radiotherapy beam.Type: GrantFiled: July 9, 2010Date of Patent: March 3, 2015Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Dan Ruan, Paul J. Keall, Amit Sawant
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Patent number: 8849373Abstract: A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.Type: GrantFiled: May 12, 2008Date of Patent: September 30, 2014Assignee: Stanford UniversityInventors: Paul J. Keall, Amit Sawant, Peter Maxim, Yelin Suh, Lei Xing, Billy W. Loo, Jr., Byung Chul Cho
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Patent number: 8331531Abstract: The present invention provides a radiotherapy treatment apparatus that includes a treatment beam, a magnetic field disposed parallel collinear to the treatment beam, and a target that is disposed along the treatment beam. The treatment beam can be a charged particle beam, a proton beam, an electron beam, or a linear accelerator (Linac) beam. The magnetic field is from a magnetic resonance imager (MRI), a megavolt x-ray imager, or a kilovolt x-ray imager and is disposed to operate in coordination with operation of the treatment beam and to narrow the beam. The tumor is disposed to rotate with respect to the treatment beam and the magnetic field, or the treatment beam and the magnetic field are disposed to rotate up to 360° with respect to the target when mounted to a ring gantry. The apparatus can include a rotation angle dependent shim disposed to account for Earth's magnetic field.Type: GrantFiled: March 15, 2010Date of Patent: December 11, 2012Assignees: The Board of Trustees of the Leland Stanford Junior University, The Regents of the University of CaliforniaInventors: Rebecca Fahrig, Norbert J. Pelc, Kim Pauly, Greig C. Scott, Amit Sawant, Paul J. Keall, Lei Xing, Steven M. Conolly
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Publication number: 20120099704Abstract: A method of multileaf collimator (MLC) leaf positioning in tracking-based adaptive radiotherapy is provided. The method includes determining a radiotherapy beam pattern by transforming a treatment beam plan into radiotherapy beam coordinates, determining a dose discrepancy between the radiotherapy beam pattern and a deliverable MLC aperture, where the dose discrepancy includes a sum of an overdose cost and an underdose cost to a treatment volume, and minimizing the dose discrepancy, where the dose discrepancy minimization provides a determined deliverable MLC aperture for the radiotherapy beam.Type: ApplicationFiled: July 9, 2010Publication date: April 26, 2012Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Dan Ruan, Paul J. Keall, Amit Sawant
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Publication number: 20100239066Abstract: The present invention provides a radiotherapy treatment apparatus that includes a treatment beam, a magnetic field disposed parallel collinear to the treatment beam, and a target that is disposed along the treatment beam. The treatment beam can be a charged particle beam, a proton beam, an electron beam, or a linear accelerator (Linac) beam. The magnetic field is from a magnetic resonance imager (MRI), a megavolt x-ray imager, or a kilovolt x-ray imager and is disposed to operate in coordination with operation of the treatment beam and to narrow the beam. The tumor is disposed to rotate with respect to the treatment beam and the magnetic field, or the treatment beam and the magnetic field are disposed to rotate up to 360° with respect to the target when mounted to a ring gantry. The apparatus can include a rotation angle dependent shim disposed to account for Earth's magnetic field.Type: ApplicationFiled: March 15, 2010Publication date: September 23, 2010Inventors: Rebecca Fahrig, Norbert J. Pelc, Kim Pauly, Greig C. Scott, Amit Sawant, Paul J. Keall, Lei Xing, Steven M. Conolly
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Patent number: 7469035Abstract: A method of continuous real-time monitoring and positioning of multi-leaf collimators during on and off radiation exposure conditions of radiation therapy to account for target motion relative to a radiation beam is provided. A prediction algorithm estimates future positions of a target relative to the radiation source. Target geometry and orientation are determined relative to the radiation source. Target, treatment plan, and leaf width data, and temporal interpolations of radiation doses are sent to the controller. Coordinates having an origin at an isocenter of the isocentric plane establish initial aperture end positions of the leaves that is provided to the controller, where motors to position the MLC midpoint aperture ends according to the position and target information. Each aperture end intersects a single point of a convolution of the target and the isocenter of the isocentric plane.Type: GrantFiled: December 11, 2007Date of Patent: December 23, 2008Assignees: The Board of Trustees of the Leland Stanford Junior University, Varian Medical Systems Technologies, Inc.Inventors: Paul J. Keall, Amit Sawant, Yelin Suh, Sergey Povzner, Herbert Cattell
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Publication number: 20080281192Abstract: A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.Type: ApplicationFiled: May 12, 2008Publication date: November 13, 2008Inventors: Paul J. Keall, Amit Sawant, Peter Maxim, Yelin Suh, Lei Xing, Billy W. Loo, JR., Byung Chul Cho
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Publication number: 20080159478Abstract: A method of continuous real-time monitoring and positioning of multi-leaf collimators during on and off radiation exposure conditions of radiation therapy to account for target motion relative to a radiation beam is provided. A prediction algorithm estimates future positions of a target relative to the radiation source. Target geometry and orientation are determined relative to the radiation source. Target, treatment plan, and leaf width data, and temporal interpolations of radiation doses are sent to the controller. Coordinates having an origin at an isocenter of the isocentric plane establish initial aperture end positions of the leaves that is provided to the controller, where motors to position the MLC midpoint aperture ends according to the position and target information. Each aperture end intersects a single point of a convolution of the target and the isocenter of the isocentric plane.Type: ApplicationFiled: December 11, 2007Publication date: July 3, 2008Inventors: Paul J. Keall, Amit Sawant, Yelin Suh, Sergey Povzner, Herbert Cattell