Abstract: An electrostatic actuator is provide that can include a fluidic line, a first electrode, and a second electrode such that a gate chamber portion of the fluidic line is sandwiched between the first electrode and the second electrode. The electrostatic actuator can also include a pressure-balancing channel in fluid communication with the gate chamber portion where the first electrode is sandwiched between the pressure-balancing channel and the gate chamber portion. A pneumatic valve system is provided which includes an electrostatic gate and a fluidic channel fluidly separate from a fluidic control line. A pneumatic valve portion of the fluidic control line can be positioned relative to a portion of the fluidic channel such that expansion of the pneumatic valve portion restricts fluid flow through the fluidic channel. Methods of using an electrostatic actuator and a pneumatic valve system are also provided.

Abstract: A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.

Abstract: A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.

Abstract: An electrostatic actuator is provide that can include a fluidic line, a first electrode, and a second electrode such that a gate chamber portion of the fluidic line is sandwiched between the first electrode and the second electrode. The electrostatic actuator can also include a pressure-balancing channel in fluid communication with the gate chamber portion where the first electrode is sandwiched between the pressure-balancing channel and the gate chamber portion. A pneumatic valve system is provided which includes an electrostatic gate and a fluidic channel fluidly separate from a fluidic control line. A pneumatic valve portion of the fluidic control line can be positioned relative to a portion of the fluidic channel such that expansion of the pneumatic valve portion restricts fluid flow through the fluidic channel. Methods of using an electrostatic actuator and a pneumatic valve system are also provided.

Abstract: A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.

Abstract: Systems and methods for constructing a series of interactions with a user to collect multiple pieces of related information for the purpose of accomplishing a specific goal or topic (a multi-slot dialog) using a component-based approach are disclosed. The method generally includes outputting a primary header prompt to elicit values for slots in a segment from the user, receiving a primary user response containing a value for each slot in at least a subset of the slots in the segment, processing the primary user response to determine at least one possible recognition value for each slot contained in the primary user response, filling each slot contained in the primary user response with a matched value selected from the corresponding possible recognition values, and repeating the outputting, receiving, processing and filling for any unfilled slots in the segment until all slots in the segment of slots are filled.

Abstract: The present invention is directed to a computer implemented method and apparatus for flexibly recognizing meaningful data items within an arbitrary user utterance. According to one example embodiment of the invention, a set of one or more key phrases and a set of one or more filler phrases are defined, probabilities are assigned to the key phrases and/or the filler phrases, and the user utterances is evaluated against the set of key phrases and the set of filler phrases using the probabilities.

Abstract: Systems and methods for providing dynamic on-demand directions with targeted advertisements are disclosed.

Abstract: A vigilance monitoring system to determine the alertness of a driver of a vehicle. The system uses one or multiple sensors located at the driver-vehicle interface (steering wheel, accelerator, brakes). The sensor monitors the magnitude and frequency of the force (or displacement) exerted by a driver at the driver interface. A time derivative of the force or displacement profile is created. The variability of the time derivative of the force/displacement data from the general trend of the data as obtained by an optimized moving average of the data. An intelligent control system measures the variability and compares with an alertness rating scale to determine the alertness score of the driver and issue warning signals and actions as appropriate.

Abstract: Systems and methods for constructing a series of interactions with a user to collect multiple pieces of related information for the purpose of accomplishing a specific goal or topic (a multi-slot dialog) using a component-based approach are disclosed. The method generally includes outputting a primary header prompt to elicit values for slots in a segment from the user, receiving a primary user response containing a value for each slot in at least a subset of the slots in the segment, processing the primary user response to determine at least one possible recognition value for each slot contained in the primary user response, filling each slot contained in the primary user response with a matched value selected from the corresponding possible recognition values, and repeating the outputting, receiving, processing and filling for any unfilled slots in the segment until all slots in the segment of slots are filled.