Abstract: This application sets forth techniques for mitigating radio frequency (RF) interference from wired connections on cellular wireless reception quality, including pre-emptively determining when to perform RF interference mitigation based on various factors. An interference mitigation module in the wireless device determines whether to perform an interference mitigation procedure based on active and/or imminent use of a high-speed wired connection port for data transfer in parallel with a cellular wireless connection that uses a mid-frequency RF band or a high-frequency RF band. The wireless device determines a target cell in a low-frequency RF band and biases measurement reports sent to a cellular wireless network to handover and keep the cellular wireless connection to the target cell in the low-frequency RF band while a high-speed wired connection is active.